Summary
This investigation is concerned with pineal organs of human embryos 60 to 150 days old. At every stage central nerve fibres enter the pineal organ by way of the habenular commissure, but are restricted to the pineal's proximal part. On about the 60th day of the development the sympathetic nervus conarii grows into the distal pole of the pineal organ from a dorso-caudal direction and plays the predominant part in the innervation of the pineal organ. After penetrating, it soon branches out and forms a network in the pineal tissue. Much later, not until the 5th embryonic month, sympathetic nerves appear accompanying the supplying vessels in the perivascular spaces. After a short time these nerves pierce the outer limiting basement membrane and penetrate the parenchyma. Towards the end of the 5th embryonic month the axons of the sympathetic nerves form varicosities containing clear and dense core vesicles. At this point large amounts of laminated granules appear primarily in cell processes, probably of pinealocytes. Isolated granules also occur in the varicosities of axons. The granules encountered here are most likely secretory granules.
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Anderson, E.: The anatomy of bovine and ovine pineals. Light and electron microscopic studies. J. Ultrastruct. Res., Suppl. 8, 1–80 (1965).
Bargmann, W.: Die Epiphysis cerebri. In: Handbuch der mikroskopischen Anatomie des Menschen, ed. W. v. Möllendorff, Bd. VI/4, S. 308–502. Berlin: Springer 1943.
Bertler, A., Falck, B., Owman, Ch.: Cellular localization of 5-hydroxytryptamine in the rat pineal gland. Kungl. Fysiogr. Sällsk Lund Förh. 33, 13–16 (1963).
Fitzpatrick, T. B., Quevedo, W. C., Jr., Levene, A. L., McGovern, V. J., Mishima, Y., Oettle, A. G.: Terminology of vertebrate melanin-containing cells, their precursors and related cells: A report of the Nomenclature Commitee of the Sixth Int. Pigment Cell Conf. Sofia 1965. In: Della Porta, G., Mühlbock, O. Structure and control of the melanocyte. Berlin-Heidelberg-New York: Springer 1966.
Hartmann, F.: Über die Innervation der Epiphysis cerebri einiger Säugetiere. Z. Zellforsch. 46, 416–429 (1957).
Hochstetter, F.: Über die Entwicklung der Zirbeldrüse des Menschen. Anat. Anz. 54, Erg. Heft 193–198 (1921).
Ito, S., Winchester, R. J.: The fine structure of gastric mucosa in the bat. J. Cell Biol. 16, 541–577 (1963).
Kappers, J. Ariëns: The development, topographical relations and innervation of the epiphysis cerebri in the albino rat. Z. Zellforsch. 52, 163–215 (1960).
—: Survey of the innervation of the epiphysis cerebri and the accessory pineal organs of vertebrates. Progr. Brain Res. 10, 87–153 (1965).
—: On the innervation of the pineal organs and on their function in relation to their innervation. In: Aus der Werkstatt des Anatomen, ed. W. Bargmann. Stuttgart: Thieme 1965.
—: The mammalian pineal organ. In: Neurohormones and neurohumors, ed. J. Ariëns Kappers. J. Neuro-Visceral Relations, Suppl. IX. Wien-New York: Springer 1969.
Kelly, D. E.: Pineal anatomy. In: The pineal, ed. Wurtman, Axelrod, Kelly. New York: Academic Press 1968.
Kenny, C. G. T.: The “Nervus conarii” of the monkey. J. Neuropath. exp. Neurol. 20, 563–570 (1961).
—: The innervation of the mammalian pineal body. A comparative study. Proc. Austral. Ass. Neurol. 3, 133–141 (1965).
Kolmer, W., Loewy, R.: Beiträge zur Physiologie der Zirbeldrüse. Pflügers Arch. ges. Physiol. 196, 1–14 (1922).
Krabbe, K. H.: Histologische und embryologische Untersuchungen über die Zirbeldrüse des Menschen. Anat. Hefte 54, 191–317 (1917).
Le Gros Clark, W. E.: The nervous and vascular relations of the pineal gland. J. Anat. (Lond.) 74, 471–492 (1939/40).
Luft, J. H.: Improvements in epoxy resin embedding methods. J. biophys. biochem. Cytol. 9, 409–414 (1961).
Owman, Ch.: Localization of neuronal and parenchymal monoamines under normal and experimental conditions in the mammalian pineal gland. Progr. Brain Res. 10, 423–453 (1965).
Pastori, G.: Ein bis jetzt noch nicht beschriebenes sympathisches Ganglion und dessen Beziehung zum Nervus conarii, sowie zur Vena magna Galeni. Z. ges. Neurol. Psychiat. 123, 81–90 (1930).
Pellegrino de Iraldi, A., Zieher, L. M., de Robertis, E.: Ultrastructure and pharmacological studies of nerve endings in the pineal organ. Progr. Brain Res. 10, 389–422 (1965).
Quast, P.: Beiträge zur Histologie und Cytologie der normalen Zirbeldrüse des Menschen. I. Das Parenchympigment der Zirbeldrüse. Z. mikr.-anat. Forsch. 23, 335–434 (1931).
—: Beiträge zur Histologie und Cytologie der normalen Zirbeldrüse des Menschen. II. Zellen und Pigment des interstitiellen Gewebes der Zirbeldrüse. Z. mikr.-anat. Forsch. 24, 38–100 (1931).
Reynolds, E. S.: The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J. Cell Biol. 17, 208–212 (1963).
Scharenberg, K., Liss, L.: The histologic structure of the human pineal body. Progr. Brain Res. 10, 193–217 (1965).
Sheridan, M. N., Reiter, R. J.: The fine structure of the hamster pineal gland. Amer. J. Anat. 122, 357–376 (1968).
Studnička, F. K.: Die Parietalorgane. In: Lehrbuch der vergleichenden mikroskopischen Anatomie der Wirbeltiere, ed. A. Oppel, Bd. 5. Jena 1905.
Trump, B. F., Smuckler, E. A., Benditt, E. P.: A method for staining epoxy sections for light microscopy. J. Ultrastruct. Res. 5, 343–348 (1961).
Turkewitsch, N.: Die Entwicklung der Zirbeldrüse des Menschen. Gegenbauers morph. Jb. 72, 379–445 (1933).
Uemura, S.: Zur normalen und pathologischen Anatomie der Glandula pinealis des Menschen und einiger Haustiere. Frankfurt. Z. Path. 20, 381–488 (1917).
Wartenberg, H.: The mammalian pineal organ: Electron microscopic studies on the fine structure of pinealocytes, glial cells and on perivascular compartments, Z. Zellforsch. 86, 74–97 (1968).
—: Vergleichende Untersuchungen über das Vorkommen von biogenen Aminen in den circumventriculären Organen von Reptilien und Säugern. In: Zirkumventrikuläre Organe und Liquor, ed. G. Sterba, S. 161–165. Jena: Fischer 1968.
Wolfe, D. E.: The epiphyseal cell: an electron-microscopic study on its intercellular relationships and intracellular morphology in the pineal body of the albino rat. Progr. Brain Res. 10, 332–386 (1965).
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Dedicated to Professor Bargmann on his 65th birthday.
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Hülsemann, M. Development of the innervation in the human pineal organ. Z. Zellforsch. 115, 396–415 (1971). https://doi.org/10.1007/BF00324942
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DOI: https://doi.org/10.1007/BF00324942