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The reinforcement-extinction process of selector gene activity: a positive feed-back loop and cell-cell interactions in Ultrabithorax patterning

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Summary

Most viable alleles of homeotic genes cause partial transformations within given lineages in a topographically specific fashion. We study this phenomenon as a way to understand the normal mechanisms involved in the spatial regulation of homeotic gene expression. To this end we have investigated the distribution of Ultrabithorax (Ubx) proteins in imaginai discs mutant for hypomorphic and neomorphic alleles of Ubx and alleles of trans-acting genes. We find that the morphological discontinuities observed in the adult transformations are caused by corresponding new patterns of the Ubx proteins in the imaginai anlagen. These novel patterns of Ubx proteins are understood as a consequence of a process of reinforcement-extinction of Ubx expression. The evidence suggesting that this process results from a positive feed-back loop and cell-cell interactions is discussed.

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Author notes

  1. Juan Botas

    Present address: Department of Biochemistry, Stanford School of Medicine, 94305, Stanford, CA, USA

  2. Carlos V. Cabrera

    Present address: MRC Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK

Authors and Affiliations

  1. Institute de Biologia Molecular, CSIC-UAM, 28049, Madrid, Spain

    Juan Botas, Carlos V. Cabrera & Antonio Garcia-Bellido

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  1. Juan Botas
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  2. Carlos V. Cabrera
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  3. Antonio Garcia-Bellido
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Botas, J., Cabrera, C.V. & Garcia-Bellido, A. The reinforcement-extinction process of selector gene activity: a positive feed-back loop and cell-cell interactions in Ultrabithorax patterning. Roux's Arch Dev Biol 197, 424–434 (1988). https://doi.org/10.1007/BF00398994

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