Skip to main content
Log in

Polymorphic variations in the ori sequences from the mitochondrial genomes of different wild-type yeast strains

  • Published:
Current Genetics Aims and scope Submit manuscript

Summary

We determined the restriction maps and primary structures of two as yet poorly characterized regions of the mitochondrial genomes of different wildtype strains of Saccharomyces cerevisiae. These regions respectively comprised the ori1 sequence and the newly identified ori8 sequence. Ori1 and ori8, together with their flanking sequences, exhibit a large polymorphism, resulting from specific variations due to insertions or deletions of optional GC clusters at different locations. The mechanisms underlying such sequence rearrangements are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Baldacci G, Bernardi G (1982) EMBO J 1:987–994

    Google Scholar 

  • Baldacci G, Bernardi G (1983) The replication of yeast mitochondrial DNA. In: Schweyen RJ, Wolf K, Kaudewitz F (eds) Mitochondria 1983. de Gruyter, Berlin, pp 57–63

    Google Scholar 

  • Baldacci G, Chérif-Zahar B, Bernardi G (1984) EMBO J 3:2115–2120

    Google Scholar 

  • Bernardi G, Prunell A, Kopecka H (1975) An analysis of the mitochondrial genome of yeast with restriction enzymes. In: Puiseux-Dao S (ed) Molecular biology of nucleocytoplasmic relationships. Elsevier, Amsterdam, pp 84–90

    Google Scholar 

  • Blanc H, Dujon B (1980) Proc Natl Acad Sci USA 77:3942–3946

    Google Scholar 

  • Blanc H, Dujon B (1982) Replicator regions of the yeast mitochondrial DNA active in vivo and in yeast transformants. In: Slonimski PP, Borst P, Attardi G (eds) Mitochondrial genes. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp 279–294

    Google Scholar 

  • Bonitz SG, Coruzzi G, Thalenfeld BE, Tzagoloff A (1980) J Biol Chem 255:11922–11926

    Google Scholar 

  • Christianson T, Edwards JC, Levens D, Locker J, Rabinowitz M (1982) J Biol Chem 257:6494–6500

    Google Scholar 

  • Christianson T, Rabinowitz M (1983) J Biol Chem 258:14025–14033

    Google Scholar 

  • Clayton DA (1982) Cell 28:693–705

    Google Scholar 

  • Cobon GS, Beilharz MW, Linnane AW, Nagley P (1982) Curr Genet 5:97–107

    Google Scholar 

  • Colin Y, Baldacci G, Bernardi G (1985) Gene 36:1–13

    Google Scholar 

  • Coruzzi G, Bonitz SG, Thalenfeld BE, Tzagoloff A (1981) J Biol Chem 256:12780–12787

    Google Scholar 

  • de Zamaroczy M, Marotta R, Faugeron-Fonty G, Goursot R, Mangin M, Baldacci G, Bernardi G (1981) Nature (London) 292:75–78

    Google Scholar 

  • de Zamaroczy M, Faugeron-Fonty G, Bernardi G (1983) Gene 51:193–202

    Google Scholar 

  • de Zamaroczy M, Faugeron-Fonty G, Baldacci G, Goursot R, Bernardi G (1984) Gene 32:439–457

    Google Scholar 

  • Dujon B (1980) Cell 20:185–197

    Google Scholar 

  • Faugeron-Fonty G, Culard F, Baldacci G, Goursot R, Prunell A, Bernardi G (1979) J Mol Biol 134:493–537

    Google Scholar 

  • Faugeron-Fonty G, Mangin M, Huyard A, Bernardi G (1983) Gene 24:61–71

    Google Scholar 

  • Faugeron-Fonty G, Le Van Kim C, de Zamaroczy M, Goursot R, Bernardi G (1984) Gene 32:459–473

    Google Scholar 

  • Fonty G, Goursot R, Wilkie D, Bernardi G (1978) J Mol Biol 119:213–235

    Google Scholar 

  • Gaillard C, Bernardi G (1979) Mol Gen Genet 174:335–337

    Google Scholar 

  • Gaillard C, Strauss F, Bernardi G (1980) Nature (London) 283:218–220

    Google Scholar 

  • Goursot R, Mangin M, Bernardi G (1982) EMBO J 1:705–711

    Google Scholar 

  • Goyon C (1984) Contribution à l'étude des remaniements dans les séquences ori du génome mitochondrial de la levure. Diplôme d'Etudes Approfondies, Univ. Paris VI

  • Hensgens LAM, Arnberg AC, Roosendaal E, Van den Horst G, Van den Veen R, Van Ommen G-JB, Grivell LA (1983) J Mol Biol 164:35–38

    Google Scholar 

  • Hudspeth MES, Vincent RD, Perlman PS, Shumard SD, Treisman LO, Grossman LI (1984) Proc Natl Acad Sci USA 81:3148–3152

    Google Scholar 

  • Le Van Kim C (1981) Contribution à l'étude de la suppressivíté chez la levure Saccharomyces cerevisiae. Diplôme d'Etudes Approfondies, Univ. Paris VII

  • Mahler HR (1983) Int Rev Cytol 82:1–98

    Google Scholar 

  • Mangin M, Faugeron-Fonty G, Bernardi G (1983) Gene 24:73–81

    Google Scholar 

  • Martin RP, Bordonné R, Dirheimer G (1982) The paromomycin region in the yeast mitochondrial genome. In: Akoyounoglou G, Evangelopoulos EA, Georgatsos J, Palaiologos G, Trakatellis A, Tsiganos CP (eds) Cell function and differentiation, part B. Liss, New York, pp 355–365

    Google Scholar 

  • Messing J, Vieira J (1982) Gene 19:269–276

    Google Scholar 

  • Nobrega FG, Tzagoloff A (1980) J Biol Chem 255:9828–9837

    Google Scholar 

  • Osinga KA, Tabak HF (1982) Nucleic Acids Res 10:3617–3626

    Google Scholar 

  • Osinga KA, De Vries E, Van der Horst GTJ, Tabak HF (1984) Nucleic Acids Res 12:1889–1900

    Google Scholar 

  • Prunell A, Bernardi G (1977) J Mol Biol 110:53–74

    Google Scholar 

  • Prunell A, Kopecka H, Strauss F, Bernardi G (1977) J Mol Biol 110:17–52

    Google Scholar 

  • Sanders JPM, Heyting C, Verbeert MP, Meijlink FCPW, Borst P (1977) Mol Gen Genet 157:239–261

    Google Scholar 

  • Sanger F, Nicklen S, Coulson AR (1977) Proc Natl Acad Sci USA 74:5463–5467

    Google Scholar 

  • Sor F, Fukuhara H (1982a) Nucleic Acids Res 10:1625–1633

    Google Scholar 

  • Sor F, Fukuhara H (1982b) Nucleotide sequence of the small ribosomal RNA gene from the mitochondria of Saccharomyces cerevisiae. In: Slonimski PP, Borst P, Attardi G (eds) Mitochondrial genes. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp 255–262

    Google Scholar 

  • Sor F, Fukuhara H (1983) Nucleic Acids Res 11:339–348

    Google Scholar 

  • Wolf K, Dujon B, Slonimski PP (1973) Mol Gen Genet 125:53–90

    Google Scholar 

  • Zassenhaus HP, Butow R (1983) Functions of non-genic DNA in yeast mitochondria. In: Schweyen RJ, Wolf K, Kaudewitz F (eds) Mitochondria 1983. De Gruyter, Berlin, pp 95–106

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Faugeron-Fonty, G., Goyon, C. Polymorphic variations in the ori sequences from the mitochondrial genomes of different wild-type yeast strains. Curr Genet 10, 269–282 (1985). https://doi.org/10.1007/BF00365623

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00365623

Key words

Navigation