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The influence of preculture on the process performance of penicillin V production in a 100-l air-lift tower loop reactor

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Summary

The influence of stirrer speed in the third preculture on the performance of penicillin V production by Penicillium chrysogenum in complex medium in a 100-l air-lift tower loop reactor was investigated. The process performance in the main culture was improved by increasing the stirrer speed from 500 to 750 rpm: the pellet size was reduced to half, the cell growth was influenced only slightly, but the production phase was extended considerably, and the final penicillin concentration was increased from 5.1 g 1-1 to 10.4 g 1-1.

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Authors and Affiliations

  1. Institut für Technische Chemie, Universität Hannover, Callinstasse 3, W-3000, Hannover, Federal Republic of Germany

    J. Möller, J. Niehoff, S. Hotop, M. Dors & K. Schügerl

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  1. J. Möller
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  2. J. Niehoff
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  3. S. Hotop
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  4. M. Dors
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  5. K. Schügerl
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Möller, J., Niehoff, J., Hotop, S. et al. The influence of preculture on the process performance of penicillin V production in a 100-l air-lift tower loop reactor. Appl Microbiol Biotechnol 37, 157–163 (1992). https://doi.org/10.1007/BF00178163

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  • DOI: https://doi.org/10.1007/BF00178163

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