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Peptide map analysis of mutant transplantation antigens

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Abstract

H-2K antigens from two histocompatibility mutants, M506 (H-2Kfa) and M523 (H-2Kka) and from their parental strains, A.CA (H-2kf) and CBA (H-2Kk), are compared by ion exchange chromatography of tryptic peptides. Both mutant molecules differ from their parental counterparts by only one or two peptides. These results are discussed with reference to the alterations in serological and biological properties exhibited by the two mutations.

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Authors and Affiliations

  1. Division of Biology, California Institute of Technology, 91125, Pasadena, California

    Sandra J. Ewald & Leroy E. Hood

  2. Max Planck Institute for Biology, Corrensstrasse 42, 7400, Tübingen 1, Federal Republic of Germany

    Jan Klein

Authors
  1. Sandra J. Ewald
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  2. Jan Klein
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  3. Leroy E. Hood
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Ewald, S.J., Klein, J. & Hood, L.E. Peptide map analysis of mutant transplantation antigens. Immunogenetics 8, 551–559 (1979). https://doi.org/10.1007/BF01561464

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  • DOI: https://doi.org/10.1007/BF01561464

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