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Mouse serum amyloid P-component (SAP) levels controlled by a locus on chromosome 1

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Abstract

Recombinant inbred strains were used to demonstrate the existence of a major locus on chromosome 1, designated Sap, which controls the endogenous concentration of the mouse acute phase reactant, serum amyloid P-component (SAP). Levels of SAP were associated with alleles at the Ly-9 locus in two sets of RI strains: BXD (C57BL/6J × DBA/2) and BXH (C57BL/6J × C3H/HeJ). Low endogenous levels of SAP were present in the C57BL/6J progenitor strain and in most of the RI strains which inherited the Ly-9 ballele. High levels of SAP were present in the DBA/2J and C3H/HeJ progenitors and in most of the RI strains which inherited the Ly-9 aallele. In the BXD strains 91% of the genetic variation of SAP levels was accounted for by segregation at the Ly-9 locus while an additional 9% was attributed to genetic factors unlinked to Ly-9. In the BXH strains the percentage of genetic variation accounted for by Ly-9 segregation was reduced to 46%, while 54% was accounted for by other genetic factors. Because of background genetic variation it was not possible to detect any crossovers between Sap and Ly-9. However, in the BXD strains the linkage between Sap and Ly-9 appears to be quite close. The B6.C-H-25 ccongenic strain, which carries a segment of BALB/c chromosome 1 including the minor histocompatibility locus H-25 on a C57BL/6By background, had the same endogenous SAP level as the BALB/c donor strain.

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Authors and Affiliations

  1. Department of Microbiology, Ohio State University, 484 W. 12th Avenue, 43210, Columbus, Ohio

    Richard F. Mortensen & Phong T. Let

  2. The Jackson Laboratory, 04609, Bar Harbor, Maine

    Benjamin A. Taylor

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  1. Richard F. Mortensen
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  2. Phong T. Let
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  3. Benjamin A. Taylor
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Mortensen, R.F., Let, P.T. & Taylor, B.A. Mouse serum amyloid P-component (SAP) levels controlled by a locus on chromosome 1. Immunogenetics 22, 367–375 (1985). https://doi.org/10.1007/BF00430920

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