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Experimental allergic orchitis in mice

I. Genetic control of susceptibility and resistance to induction of autoimmune orchitis

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Abstract

Inbred strains of mice were studied for their susceptibility to the induction of experimental allergic orchitis after sensitization with mouse testicular homogenate in complete Freund's adjuvant accompanied by injections of extract from Bordetella pertussis. Susceptibility to autoimmune orchitis was found to be linked to the major histocompatibility complex in BALB/c and C57BL/10 mice and mapped to genes encoded within the H-2D dregion. In five of six groups of bidirectional (susceptible × resistant) F1 hybrids, H-2D d-linked susceptibility was inherited as a dominant autosomal trait. However, in (BALB/cByJ × DBA/2J)F1 and (DBA/2J × BALB/cByJ)F1 hybrids, dominant autosomal resistance to the induction of autoimmune orchitis was observed. Backcross analysis between the resistant F1 hybrid and the susceptible BALB/cByJ parent suggests that a single independently segregating DBA/2J locus is capable of negating H-2D d-linked susceptibility, and controls resistance to the induction of autoimmune orchitis.

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Abbreviations

BP extract:

Bordetella pertussis extract

CFA:

complete Freund's adjuvant

EAO:

experimental allergic orchitis

Ir:

immune response

MHC:

major histocompatibility complex

MLH:

mouse liver homogenate

MTH:

mouse testis homogenate

PI:

pathology index

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Authors and Affiliations

  1. Departments of Pathology and Microbiology, The University of New Mexico School of Medicine, 87131, Albuquerque, New Mexico

    Cory Teuscher, Suzanne M. Smith, Ellen H. Goldberg, Gene M. Shearer & Kenneth S. K. Tung

  2. National Cancer Institute, National Institutes of Health (NIH), The Immunology Branch, 20205, Bethesda, Maryland

    Cory Teuscher, Suzanne M. Smith, Ellen H. Goldberg, Gene M. Shearer & Kenneth S. K. Tung

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  1. Cory Teuscher
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  2. Suzanne M. Smith
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  4. Gene M. Shearer
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  5. Kenneth S. K. Tung
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Teuscher, C., Smith, S.M., Goldberg, E.H. et al. Experimental allergic orchitis in mice. Immunogenetics 22, 323–333 (1985). https://doi.org/10.1007/BF00430916

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  • DOI: https://doi.org/10.1007/BF00430916

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