Summary
A two-compartment model of 73HNA distribution has been developed for studying sympatho-adrenergic activity in intact man. After infusion of 73HNA at constant speed in resting normal subjects, the decay curves of the plasma concentration and urinary excretion of 73HNA were plotted against time. Analysis of the curves yielded constants and indirect indications about noradrenaline exchange processes in the extracellular environment. Complete evaluation of the neuronal pools and of the pathways of biosynthesis and metabolism was impossible, but it seemed likely that 73HNA entered small neuronal pools that underwent rapid exchange with the extracellular environment, a point of some interest in clinical and pharmacologic investigations.
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Bufano, G., Vaona, G. & Starcich, R. Approach to the pharmacokinetics of dl-7-3H-noradrenaline. Eur J Clin Pharmacol 6, 88–92 (1973). https://doi.org/10.1007/BF00562432
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DOI: https://doi.org/10.1007/BF00562432