Summary
Infusion of a therapeutic dose of sparteine sulphate, increased the basal plasma insulin level and lowered plasma glucose. When an intravenous glucose tolerance test was performed with the infusion, the total insulin AUC was significantly larger than in absence of sparteine (2025 vs 1464 µU/ml×min), plasma glucose levels were lower and improved glucose utilization was observed (kg:1.55 vs 1.39%). In the presence of arginine, sparteine sulphate stimulated both β and α cells, increasing both the total insulin (1907 vs 1516 µU/ml×minp<0.02) and total glucagon AUCs (7616±654 vs 6789±707 pg/ml×minp<0.01). Thus, sparteine sulphate increased both basal and nutrient-induced insulin and glucagon secretion in normal man.
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Sgambato, S., Paolisso, G., Passariello, N. et al. Effect of sparteine sulphate upon basal and nutrient-induced insulin and glucagon secretion in normal man. Eur J Clin Pharmacol 32, 477–480 (1987). https://doi.org/10.1007/BF00637673
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DOI: https://doi.org/10.1007/BF00637673