Skip to main content
Log in

Increase in lipolysis and decrease in plasma-heparin lipoprotein lipase activity and alpha1lipoprotein level after aminophylline in man

  • Originals
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Summary

Intravenous aminophylline 0.48 g produced a sharp increase in plasma free fatty acids. After three days of treatment with aminophylline 0.96 g/day i. v., plasma post-heparin lipoprotein lipase was significantly reduced, and post-heparin hepatic triglyceridase remained unchanged. Alpha1lipoprotein was reduced by treatment, in parallel with lipoprotein lipase, while other lipoprotein fractions, serum cholesterol and triglycerides were unaffected.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Butcher RW, Sutherland EW (1962) Adenosine-3′-5′-phosphate in biological materials. J Biol Chem 237: 1244–1250

    Google Scholar 

  2. Nikkila EA, Pykalisto O (1968) Regulation of adipose tissue lipoprotein lipase synthesis by intracellular free fatty acid. Life Sci 7: 1303–1309

    Google Scholar 

  3. Krauss RM, Levy RI, Fredrickson DS (1974) Selective measurement of two lipase activities in post-heparin plasma from normal subjects and patients with hyperlipoproteinemia. J Clin Invest 54: 1107–1124

    Google Scholar 

  4. Babson HL, Shapiro PO, Phillips GE (1962) A new assay for cholesterol and cholesterol esters which is not affected by bilirubin. Clin Chim Acta 7: 800–804

    Google Scholar 

  5. Eggstein M (1966) Eine neue Bestimmung der Neutralfette in Blutserum und Gewebe. Klin Wochenschr 44: 267–273

    Google Scholar 

  6. Dole VP, Meinertz M (1960) Microdetermination of longchain fatty acids in plasma and tissues. J Biol Chem 235: 2595–2599

    Google Scholar 

  7. Hill JB, Kessler G, Chacey NY (1961) An automated determination of glucose utilizing a glucose-oxidase-peroxidase system. J Lab Clin Med 75: 970–980

    Google Scholar 

  8. Hatch FT, Lindgren FT, Adamson CL, Jensen LC, Wang AW, Levy RI (1973) Quantitative agarose gel electrophoresis of plasma lipoproteins: a simple technique and two methods for standardization. J Lab Clin Med 81: 946–960

    Google Scholar 

  9. Fasoli A, Sommariva D, Scotti L, Massaroli C, Negrati M (1978) An evaluation of quantitative agarose gel electrophoresis of serum lipoproteins. Clin Chim Acta 87: 342–345

    Google Scholar 

  10. Sommariva D, Zanaboni L, Bonfiglioli D, Cogo R, Fasoli A (1980) Evidence of an effect of inhaled disodium cromoglycate on lipid metabolism in man: enhanced lipolysis and decreased plasma post-heparin lipase activities. Int J Clin Pharmacol Ther Toxicol 18: 122–127

    Google Scholar 

  11. Wing DR, Robinson DS (1968) Clearing-factor lipase in adipose tissue. A possible role of adenosine-3′-5′-cyclic monophosphate in the regulation of its activity. Biochem J 109: 841–849

    Google Scholar 

  12. Nikkila EA, Pykalisto O (1968) Induction of adipose tissue lipoprotein lipase by nicotinic acid. Biochim Biophys Acta 152: 421–423

    Google Scholar 

  13. Nikkila EA, Hormila P (1978) Serum lipids and lipoproteins in insulin-treated diabetes. Demonstration of increased high density lipoprotein concentrations. Diabetes 27: 1078–1086

    Google Scholar 

  14. Goldberg AP, Applebaum-Bowden DM, Bierman EL, Hazzard WR, Haas LB, Sherrard DJ, Brunzell JD, Huttunen JK, Ehnholm C, Nikkila EA (1979) Increase in lipoprotein lipase during clofibrate treatment of hypertriglyceridemia in patients on hemodialysis. N Engl J Med 301: 1073–1076

    Google Scholar 

  15. Patsch JR, Gotto AM, Olivecrona T, Eisenberg S (1978) Formation of high density lipoprotein2 like particles during lipolysis of very low density lipoprotein in vitro. Proc Natl Acad Sci USA 75: 4519–4523

    Google Scholar 

  16. Miller GJ, Miller NE (1975) Plasma high-density lipoprotein concentration and development of ischaemic heart disease. Lancet 1: 16–19

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zanaboni, L., Bonfiglioli, D., Sommariva, D. et al. Increase in lipolysis and decrease in plasma-heparin lipoprotein lipase activity and alpha1lipoprotein level after aminophylline in man. Eur J Clin Pharmacol 19, 349–351 (1981). https://doi.org/10.1007/BF00544585

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00544585

Key words

Navigation