Summary
Mitochondria isolated from the livers of rats administered with sodium meta-, ortho-, or polyvanadate, but not vanadyl sulphate, exhibited enhanced Ca2+ — stimulated respiration and uptake of calcium. These effects were shown also by mitochondria isolated from livers perfused with polyvanadate. The concentration of acid-soluble calcium decreased significantly in the mitochondrial fraction on vanadate treatment, while that in the cytosol showed a corresponding increase. Phenoxybenzamine, an antagonist to a-adrenergic receptors, effectively inhibited vanadate-induced Ca2+ mobilization, but surgical sympathectomy was without effect. This is the first demonstration of vanadate mimicking α-adrenergic agonists in vivo.
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Gullapalli, S., Shivaswamy, V., Ramasarma, T. et al. Redistribution of subcellular calcium in rat liver on administration of vanadate. Mol Cell Biochem 90, 155–164 (1989). https://doi.org/10.1007/BF00221215
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DOI: https://doi.org/10.1007/BF00221215