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Simple vs. complex inheritance of inducible aryl hydrocarbon hydroxylase in mouse tissues

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Abstract

The genetics of induction of hepatic and lung aryl hydrocarbon hydroxylase (AHH) have been studied in Af/Ki and AKR/Ki mice and in their F1 and F2 progeny after administration of 3-methylcholanthrene (3MC). Furthermore, the induction of AHH was investigated using the fetal liver explant model system with 3MC, trans-1,2-dihydroxy-3MC, and 4′-bromoflavone as the inducers. The results obtained with the above strains were contrasted with those from the C57BL/6Ki, DBA/2+ Ki, and their crosses. The present investigation revealed a complex pattern of inheritance of basal and inducible AHH in lung and liver of AKR/Ki and Af/Ki, with a poor correlation between lung and liver. Hepatic AHH was not fully inducible in the F1 hybrids, while the frequency distribution function in the F2 mice was suggestive of more than two distinct classes.

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Author notes

  1. Kurt Bürki

    Present address: Department of Pathology, University of Bern, Bern, Switzerland

  2. A. G. Liebelt

    Present address: Northeastern Ohio Universities College of Medicine, Kent, Ohio

Authors and Affiliations

  1. Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, Georgia

    Kurt Bürki, A. G. Liebelt & Edward Bresnick

Authors
  1. Kurt Bürki
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  2. A. G. Liebelt
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  3. Edward Bresnick
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Additional information

This work was supported by a grant from the NIH (CA 12906).

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Bürki, K., Liebelt, A.G. & Bresnick, E. Simple vs. complex inheritance of inducible aryl hydrocarbon hydroxylase in mouse tissues. Biochem Genet 13, 417–433 (1975). https://doi.org/10.1007/BF00485785

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  • DOI: https://doi.org/10.1007/BF00485785

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