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Effects of tissue injury mediators on thein vitro experession of surface antigens by human lymphocytes

  • Microbiology and Immunology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

A short-term incubation of healthy donor lymphocytes with adenosine or adenosine diphosphoric acid was shown to reduce the number of cells expressing CD4 antigen and to increase the number of CD8+ lymphocytes. The hydra peptide morphogen shifts the balance of immunoregulatory lymphocytes toward a predominance of CD4+ cells. A hypothesis of a two-level system for the regulation of surface antigen expression by lymphocytes during exposure to extreme factors is proposed.

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Authors and Affiliations

  1. Russian State Medical University, Moscow

    G. V. Poryadin, Zh. M. Salmasi, A. N. Kazimirskii, A. I. Makarkov & N. I. Bozieva

Authors
  1. G. V. Poryadin
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  2. Zh. M. Salmasi
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  3. A. N. Kazimirskii
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  4. A. I. Makarkov
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  5. N. I. Bozieva
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No. 2, pp. 196–199, February, 1995

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Poryadin, G.V., Salmasi, Z.M., Kazimirskii, A.N. et al. Effects of tissue injury mediators on thein vitro experession of surface antigens by human lymphocytes. Bull Exp Biol Med 119, 189–191 (1995). https://doi.org/10.1007/BF02445875

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  • DOI: https://doi.org/10.1007/BF02445875

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