Abstract
The structure and physiology of salmon teleocalcin, a Ca+2 regulating hormone from the corpuscles of Stannius (CS) is reviewed. Teleocalcin is produced by the PAS+, type 1 cells in the CS. The hormone is a disulfide-linked homodimer, with a unique amino acid sequence and a carbohydrate moiety on residue 29. The teleocalcin monomer has a MW of 30 KD, whereas the pro-form of the monomer is 32 KD. The hormone is positively regulated by Ca+2 and its function is to slow the active transport of Ca+2 across the gill epithelium. In conjunction with prolactin, which stimulates Ca+2 transport, teleocalcin is one of the major factors involved in Ca+2 homeostasis in fish.
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Aida, K., Nishioka, R.S. and Bern, H.A. 1980. Degranulation of the corpuscles of Stannius of coho salmon (Oncorhynchus kisutch) in response to ionic changesin vitro. Gen. Comp. Endocrinol. 41: 305–3413.
Butkus, A., Roche, P.J., Fernley, R.T., Haralambidis, J., Penschow, J.D., Ryan, G.B., Trahair, J.F., Tregear, G.W. and Coghlan, J.P. 1987. Purification and cloning of a corpuscles of Stannius protein fromAnguilla australis. Mol. Cell. Endocrinol. 54: 123–134.
Butler, D.G. 1969. Corpuscles of Stannius and renal physiology in the eel (Anguilla rostrata). J. Fish. Res. Bd. Can. 26: 639–654.
Donahoe, P.K., Cate, R.L., MacLaughlin, D.T., Epstein, J., Fuller, A.F., Takahashi, M., Coughlin, J.P., Ninfa, E.G. and Taylor, L.A. 1987. Mullerian-inhibiting substance: Gene structure and mechanism of action of a fetal regressor. Rec. Progr. Horm. Res. 43: 431–467.
Fargher, R.C. 1988. Biochemical and physiological studies on salmon prolactin. Ph.D. Thesis, Simon Fraser University, Canada.
Flik, G., Fenwick, J.C., Kolar, Z., Mayer-Gostan, N. anndelaar Bonga, S.E. 1986. Effects of ovine prolactin on calcium uptake and distribution inOreochromis mossambicus. Am. J. Physiol. 250: R161–R166.
Fenwick, J.C. 1974. The corpuscles of Stannius and calcium regulation in the North American eel (Anguilla rostrata Lesueur). Gen. Comp. Endocrinol. 29: 127–135.
Fenwick, J.C. and So, Y.P. 1974. A perfusion study of the effects of Stanniectomy on the net influx of calcium-45 across an isolated eel gill. J. Exp. Zool. 188: 125–131.
Fontaine, M. 1964. Corpuscles de Stannius et regulation ionique (Ca, K, et Na) du milieu interieur d'un poisson l'anguille. C.R. Acad. Sci. Ser. D529: 875–878.
Gellersen, B., Wagner, G.F., Copp, D.H. and Friesen, H.G. 1988. Development of a primary culture system for rainbow trout corpuscles of Stannius and characterization of secreted teleocalcin. Endocrinology 123: 913–921.
Krishnamurthy, V.G. 1976. Cytophysiology of corpuscles of Stannius. Int. Rev. Cytol. 46: 177–249.
Lafeber, F.P.J.G., Hanssen, R.G.J.M., Choy, Y.M., Flik, G., Herrmann-Erlee , Pang, P.K.T. and Wendelaar Bonga, S.E. 1988. Identification of hypocalcin (teleocalcin) isolated from trout Stannius corpuscles. Gen. Comp. Endocrinol. 69: 19–30.
Ma, S.W.Y. and Copp, D.H. 1978. Purification, properties and action of a glycoprotein from the corpuscles of Stannius, which affects calcium metabolism in the teleost.In Comparative Endocrinology pp. 283–286. Edited by P.J. Gaillard and H.H. Boer. Elsevier-North-Holland, Amsterdam.
Pang, P.K.T., Pang, R.K. and Sawyer, W.H. 1973. Effects of environmental calcium and replacement therapy on the killifish,Fundulus heteroclitus, after surgical removal of the corpuscles of Stannius. Endocrinology 93: 705–710.
So, Y.P. and Fenwick, J.C. 1977. Relationship between net45calcium influx across a perfused isolated eel gill and the development of post-stanniectomy hypercalcemia. J. Exp. Zool. 200: 259–264.
So, Y.P. and Fenwick, J.C. 1979.In vivo andin vitro effects of Stannius corpuscle extract on the branchial uptake of45Ca in stanniectomized North American eel (Anguilla rostrata). Gen. Comp. Endocrinol. 37: 143–149.
Wagner, G.F., Copp, D.H. and Friesen, H.G. 1988a. Immunological studies on teleocalcin and salmon corpuscles of Stannius. Endocrinology 122: 2064–2070.
Wagner, G.F., Fenwick, J.C., Park, C.M., Milliken, C., Copp, D.H. and Friesen, H.G. 1988b. Comparative biochemistry and physiology of teleocalcin from sockeye and coho salmon. Gen. Comp. Endocrinol. 72: 237–246.
Wagner, G.F., Gellersen, B. and Friesen, H.G. 1989. Primary culture of teleocalcin cells from rainbow trout corpuscles of Stannius: Regulation of teleocalcin secretion by calcium. Mol. Cell. Endocrinol. (In press).
Wagner, G.F., Hampong, M. and Copp, D.H. 1985a. A cycle for45Ca uptake in the rainbow trout, (Salmo gairdneri), Can. J. Zool. 63: 2778–2779.
Wagner, G.F., Hampong, M., Park, C.M. and Copp, D.H. 1986a. Purification, characterization and bioassay of teleocalcin, a glycoprotein from salmon corpuscles of Stannius. Gen. Comp. Endocrinol. 63: 481–491.
Wagner, G.F. and McKeown, B.A. 1985. Cyclical growth in juvenile rainbow trout (Salmo gairdneri). Can. J. Zool. 63: 2473–2474.
Wagner, G.F. and McKeown, B.A. 1986. Development of a salmon growth hormone radioimmunoassay. Gen. Comp. Endocrinol. 62: 452–458.
Wendelaar Bonga, S.E. and Pang, P.K.T. 1986. Stannius corpuscles.In Vertebrate Endocrinology, Fundamentals and Biomedical Implications. Vol. 1. pp. 439–464. Edited by P.K.T. Pang and M.P. Schreibman. Academic Press, New York.
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Wagner, G.F., Friesen, H.G. Studies on the structure and physiology of salmon teleocalcin. Fish Physiol Biochem 7, 367–374 (1989). https://doi.org/10.1007/BF00004730
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DOI: https://doi.org/10.1007/BF00004730