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A new PLLA/PCL copolymer for nerve regeneration

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The aim of this study is to evaluate the functional and cell biological applicability of a two-ply nerve guide constructed of a PLLA/PCL (i.e. poly-l-lactide and poly-ε-caprolactone) copolymer. To do so, we performed a cytotoxicity test, a subcutaneous biodegradation test and an in situ implantation study in the sciatic nerve of the rat. The nerve guide copolymer was found to be non-toxic, according to ISO/EN standards, and it showed a mild foreign body reaction and complete fibrous encapsulation after implantation. Onset of biodegradation of the inner layer was seen after one month of implantation. After 18 months of implantation complete fragmentation was observed, as well as a secondary inflammatory response characterized by foreign body giant cell activity and phagocytosis of polymer debris. Recovery of both motor and sensory nerve function was observed in all nerve guides.

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Authors and Affiliations

  1. Center for Biomedical Technology, div. Biomaterials, University of Groningen, Oostersingel 59, 9713 EZ, Groningen, The Netherlands

    W. F. A. Den Dunnen & J. M. Schakenraad

  2. Department of Polymer Chemistry, University of Groningen, Nyenborgh 4, 9747 AG, Groningen, The Netherlands

    G. J. Zondervan & A. J. Pennings

  3. Department of Plastic Surgery, University of Groningen, Oostersingel 59, 9713 EZ, Groningen, The Netherlands

    B. Van Der Lei & P. H. Robinson

Authors
  1. W. F. A. Den Dunnen
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  2. J. M. Schakenraad
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  3. G. J. Zondervan
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  4. A. J. Pennings
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  5. B. Van Der Lei
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  6. P. H. Robinson
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Den Dunnen, W.F.A., Schakenraad, J.M., Zondervan, G.J. et al. A new PLLA/PCL copolymer for nerve regeneration. J Mater Sci: Mater Med 4, 521–525 (1993). https://doi.org/10.1007/BF00120133

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  • DOI: https://doi.org/10.1007/BF00120133

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