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A new selective insecticidal uncoupler of oxidative phosphorylation

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Summary

A new aryl hydrazone structure with high insecticidal activity against the Australian sheep blowfly,Lucilia cuprina, was shown to have a higher activity as an uncoupler of oxidative phosphorylation in insect compared to mammalian mitochondrial preparations. This compound possesses the requirements of other uncouplers in its measured pKa and lipid solubility. However, when compared to a closely related structure with similar physicochemical properties, its insecticidal and insect mitochondrial uncoupling activities are greater and it exhibits decreased mammalian toxicity corresponding to this differential biochemical selectivity.

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Author notes

  1. D. R. J. Smith

    Present address: Biotechnology Australia Pty. Ltd, P.O. Box 20, Roseville, NSW, Australia

Authors and Affiliations

  1. CSIRO Division of Applied Organic Chemistry, G.P.O. Box 4331, 3001, Melbourne, Victoria, Australia

    G. Holan & D. R. J. Smith

Authors
  1. G. Holan
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  2. D. R. J. Smith
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Additional information

Acknowledgment. We thank Mr K. Rihs for preparation of the hydrazones and Prof. Dr K.H. Büchel for supply of hydrazone III.

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Holan, G., Smith, D.R.J. A new selective insecticidal uncoupler of oxidative phosphorylation. Experientia 42, 558–560 (1986). https://doi.org/10.1007/BF01946702

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  • DOI: https://doi.org/10.1007/BF01946702

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