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Reduced tuberoinfundibular dopaminergic neuronal function in rats after long-term withdrawal of estrogen treatment

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Summary

Hypothalamic fragments from female rats treated repeatedly with estradiol valerate (EV) and bearing prolactin (PRL)-secreting tumors contained, seven months after the last EV injection, lower concentrations of dopamine (DA) than age-matched controls. Depolarizing concentrations of K+ (35 mM) and amphetamine (50 μM) evoked in PRL-secreting tumor bearing rats an endogenous DA release significantly lower than in controls.

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References

  1. MacLeod, R., in: Frontiers in Neuroendocrinology, vol. 4, p. 169. Eds W. F. Ganong and L. Martini. Raven Press, New York 1976.

    Google Scholar 

  2. Annunziato, L., and Moore, K. E., Life Sci.22 (1978) 2037.

    Article  CAS  PubMed  Google Scholar 

  3. Annunziato, L., in: Central and Peripheral Regulation of Prolactin Secretion, p. 59. Eds U. Scapagnini and R. MacLeod. Raven Press, New York 1980.

    Google Scholar 

  4. Demarest, K. T., and Moore, K. E., J. neural Transm.46 (1979) 263.

    Article  CAS  PubMed  Google Scholar 

  5. Foreman, M. M., and Porter, J. C., Endocrinology108 (1981) 800.

    Article  CAS  PubMed  Google Scholar 

  6. Perkins, N. A., and Westfall, T. C., Neuroscience3 (1978) 59.

    Article  CAS  Google Scholar 

  7. Leong, D. A., Frawley, L. S., and Neill, J. D., A. Rev. Physiol.45 (1983) 109.

    Article  CAS  Google Scholar 

  8. Demarest, K. T. and Moore, K. E., Endocrinology106 (1980) 463.

    Article  CAS  PubMed  Google Scholar 

  9. Crowley, W. R., Neuroendocrinology34 (1982) 381.

    Article  CAS  PubMed  Google Scholar 

  10. Eikenburg, D. C., Ravitz, A. J., Gudelsky, G. A., and Moore, K. E., J. neural Transm.40 (1977) 235.

    Article  CAS  PubMed  Google Scholar 

  11. Gudelsky, G. A., Nansel, D. D. and Porter, J. C., Endocrinology108 (1981) 440.

    Article  CAS  PubMed  Google Scholar 

  12. Demarest, K. T., Riegle, G. D., and Moore, K. E., Neureoendocrinology39 (1984) 193.

    Article  CAS  Google Scholar 

  13. Du Pont, A., Di Paolo, T., Gagne, B., and Barden, N., Neurosci. Lett.22 (1881) 69.

    Google Scholar 

  14. Casanueva, F., Cocchi, D., Locatelli, V., Flauto, C., Zambotti, F., Bestetti, G., Rossi, G. L., and Müller, E. E., Endocrinology110 (1982) 590.

    Article  CAS  PubMed  Google Scholar 

  15. Algeri, S., Ponzio, F., Achilli, G., and Perego, C., in: Typical and Atypical Antidepressants: Molecular Mechanisms, p. 219. Eds E. Costa and G. Racagni. Raven Press, New York 1982.

    Google Scholar 

  16. Brawer, J. R., Naftolin, F., Martin, J., and Sonnenschein, G., Endocrinology103 (1978) 501.

    Article  CAS  PubMed  Google Scholar 

  17. Brawer, J., Schipper, H., and Robaire, B., Endocrinology112 (1983) 194.

    Article  CAS  PubMed  Google Scholar 

  18. Sarkar, D. K., Gottschall, P. E., and Meites, J., Science218 (1982) 684.

    Article  CAS  PubMed  Google Scholar 

  19. Niswender, G. D., Chen, C. L., Midgley, A. R. Jr, Meites, J., and Ellis, S., Proc. Soc. exp. Biol. Med.130 (1969) 533.

    Article  Google Scholar 

  20. Cuello, A. C., Horn, A. S., Mac Key, W. V. P., and Iversen, L. L., Nature243 (1982) 465.

    Article  Google Scholar 

  21. Peuler, J. D., and Johnson, J. A., Life Sci.21 (1977) 625.

    Article  CAS  PubMed  Google Scholar 

  22. Annunziato, L., di Renzo, G. F., Amoroso, S., and Quattrone, A., Life Sci.35 (1984) 399.

    Article  CAS  PubMed  Google Scholar 

  23. Rossi, G. L., Probst, D., Panerai, A. E., Cocchi, D., Locatelli, V., and Müller, E. E., Neuroendocrinology29 (1979) 100.

    Article  CAS  PubMed  Google Scholar 

  24. Sarkar, D. K., Gottschall, P. E., Xie, Q. W., and Meites, J., Neuroendocrinology38 (1984) 498.

    Article  CAS  PubMed  Google Scholar 

  25. Sarkar, D. K., Gottschall, P. E., and Meites, J., Endocrinology115 (1984) 1269.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, 2nd School of Medicine at Naples, Via Vanvitelli 32, I-20129, Milan, Italy

    L. Annunziato, G. di Renzo, S. Amoroso & M. Taglialatela

  2. Department of Pharmacology, University of Milan, Via Vanvitelli 32, I-20129, Milan, Italy

    D. Cocchi & E. E. Müller

  3. Institute of Animal Pathology, University of Bern, CH-3000, Bern, Switzerland

    G. L. Rossi

Authors
  1. L. Annunziato
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  2. D. Cocchi
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  3. G. di Renzo
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  4. G. L. Rossi
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  5. S. Amoroso
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  6. M. Taglialatela
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  7. E. E. Müller
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Annunziato, L., Cocchi, D., di Renzo, G. et al. Reduced tuberoinfundibular dopaminergic neuronal function in rats after long-term withdrawal of estrogen treatment. Experientia 42, 425–427 (1986). https://doi.org/10.1007/BF02118641

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  • DOI: https://doi.org/10.1007/BF02118641

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