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Effects of β-hydroxybutyrate on rat embryos grown in culture

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Summary

In order to investigate further the relationship between maternal diabetes and fetal malformation, rat embryos were grown in vitro in the presence of β-hydroxybutyrate, one of the ketone bodies produced by diabetics. At 10 mM, β-hydroxybutyrate produced minor abnormalities and at 20 mM it produced major abnormalities in rat embryos.

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Authors and Affiliations

  1. Departments of Zoology and Genetics, University of Liverpool, L693BX, Liverpool

    E. A. Sheehan, F. Beck, C. A. Clarke & M. Stanisstreet

  2. Department of Anatomy, The Medical School, University of Leicester, LE1 7RH, Leicester, England

    E. A. Sheehan, F. Beck, C. A. Clarke & M. Stanisstreet

Authors
  1. E. A. Sheehan
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  2. F. Beck
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  3. C. A. Clarke
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  4. M. Stanisstreet
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Additional information

Acknowledgments. We wish to thank Mr C. Veltkamp and Mr B. Lewis for their expert assistance with the scanning electron microscopy and photography, Mr M. Smedley who suggested improvements to the manuscript, Miss A. Callaghan who prepared the manuscript, and an anonymous donor for financial support for E.A.S.

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Sheehan, E.A., Beck, F., Clarke, C.A. et al. Effects of β-hydroxybutyrate on rat embryos grown in culture. Experientia 41, 273–275 (1985). https://doi.org/10.1007/BF02002633

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  • DOI: https://doi.org/10.1007/BF02002633

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