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Effect of spironolactone on p-nitrophenol glucuronidation in isolated rat hepatocytes

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Summary

The effect of spironolactone (SP) on p-nitrophenol (PNP) glucuronidations was studied in isolated rat hepatocytes with appropriate viability conditions. A significant increase of protein concentration and PNP glucuronidation was found in the hepatocytes from SP-treated rats. Increased enzyme activity apparently was related to the SP dose. The results favor the conclusion that SP may inuce PNP glucuronidation in the hepatocyte.

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Authors and Affiliations

  1. Instituto de Fisiologia Experimental, Consejo Nactional de Investigaciones Cientificas y Tecnicas (Conicet), Universidad National de Rosario, Rosario, Argentina

    E. E. Guibert, L. S. Morisoli, J. A. Monti & E. A. Rodriguez Garay

Authors
  1. E. E. Guibert
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  2. L. S. Morisoli
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  3. J. A. Monti
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  4. E. A. Rodriguez Garay
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Additional information

Acknowledgment. This work was supported by a grant from Consejo Nacional de Investigaciones Cientificas y Técnicas (CONICET) Argentina.

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Guibert, E.E., Morisoli, L.S., Monti, J.A. et al. Effect of spironolactone on p-nitrophenol glucuronidation in isolated rat hepatocytes. Experientia 39, 527–528 (1983). https://doi.org/10.1007/BF01965189

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  • DOI: https://doi.org/10.1007/BF01965189

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