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The role of the subependymal plate in the origin of gliomas induced by ethylnitrosourea in the rat brain

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Summary

The fine structure of early cell proliferations induced transplacentally by ethylnitrosourea in the rat brain reveals that the cells show features of the undifferentiated cells of the subependymal plate: high nuclear-cytoplasmic ratio, scarcity of cell organelles and dominance of free over membrane-bound ribosomes. These findings suggest that most, if not all, gliomas induced by ethylnitrosourea originate from these primitive cells.

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Authors and Affiliations

  1. Department of Neurological Studies and Bland-Sutton Institute of Pathology, Middlesex Hospital Medical School, W1P 8AA, London, England

    P. L. Lantos

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  1. P. L. Lantos
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Additional information

Acknowledgments. I thank D. J. Cox and G. J. Pilkington for their skilful technical assistance.

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Lantos, P.L. The role of the subependymal plate in the origin of gliomas induced by ethylnitrosourea in the rat brain. Experientia 33, 521–522 (1977). https://doi.org/10.1007/BF01922250

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