Activité antifibrillante chez l'animal d'un nouveau dérivé de la phényl-éthylamine

Summary

A new synthetic phenyl-ethyl-amine derivative, the 2-[N- (3′, 4′-methylen-dioxyphenylethyl)-methylaminomethyl]-tetrahydrofuran, No. 11 081, exhibits a strong protective effect against cardiac fibrillation and arrhythmias produced by various experimental methods: against fibrillation due to aconitine 3 × 10⁻⁸ on the isolated cat's heart, it is active in a concentration of 10⁻⁶−2 × 10⁻⁶. Against cardiac arrhythmias produced in the cat by adrenaline + CHCl₃ or cyclopropane, it shows a protective effect by 5–10 mg/kg i.v. and even perorally by 50 mg/kg. In these tests, the antifibrillatory activity of the new compound seems to be roughly the same as that of α-fagarine, and higher than that of procaine.