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Zentralerregende Wirkung eines neuen Piperidinderivates

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Summary

A new piperidine derivative, the 2-diphenylmethylpiperidine, produces already in doses of 0.001 g/kg s.c. a strong increase of the spontaneous motility of various animals. On mice it has about the same potency as d-desoxy-ephedrine and is about 3 times more potent than amphetamin. It also acts markedly antagonistic on various narcotics but has practically no peripheral sympathomimetic effects.

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References

  1. L. Panizzon, Helv. chim. Acta27, 1748 (1944);29, 324 (1946).

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  5. J. Tripod, Helv. physiol. Acta10, 403 (1952).

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Authors and Affiliations

  1. Wissenschaftliche Laboratorien der CIBA Aktiengesellschaft, Basel

    J. Tripod, E. Sury & K. Hoffmann

Authors
  1. J. Tripod
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  2. E. Sury
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  3. K. Hoffmann
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Additional information

8. Mitteilung über Alkylenimin-Derivate. 7. Mitteilung sieheB. M. Iselin undK. Hoffmann, J. Am. Chem. Soc.76 (im Druck).

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Tripod, J., Sury, E. & Hoffmann, K. Zentralerregende Wirkung eines neuen Piperidinderivates. Experientia 10, 261–262 (1954). https://doi.org/10.1007/BF02157398

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  • DOI: https://doi.org/10.1007/BF02157398

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