Skip to main content
SpringerLink
Log in

Advances in Maternal-Fetal Biomedicine

Cellular and Molecular Mechanisms of Pregnancy Pathologies

  • Book
  • © 2023

Overview

Editors:
  1. Marcelo Gonzalez-Ortiz

    1. Laboratorio de Investigación Materno-Fetal (LIMaF) Departamento de Obstetricia y Ginecología, Facultad de Medicina, Universidad de Concepción, Concepción, Chile

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Contains molecular descriptions of relevant pathologies of pregnancy
  • Written by a leading group of researchers who are at the frontier of knowledge in maternal-fetal biomedicine
  • Offers an integrative view that includes clinical information and translational medicine approaches

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1428)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

About this book

This edited volumeaims to describe physiological and pathophysiological mechanisms that underlie human maternal-fetal interactions. The book emphasizes the structure and development of the fetoplacental unit, the endocrine and nutritional regulation of fetal development, nitric oxide signalling, solute carriers function and ion channels regulation in healthy pregnancies and diseases, like preeclampsia, gestational diabetes, and maternal obesity, among others. Also, we highlight novel mechanisms associated with language impairment in children, the use of serotonin inhibitors or cannabis during pregnancy, and maternal conditions' potential impact on cerebrovascular development in newborns and infants. The cellular and molecular understanding of maternal-fetal physiology and pathophysiology will allow the readers to understand the impact of diseases or conditions that are highly prevalent in pregnant women.

Keywords

Table of contents (14 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Feto-placental Unit: From Development to Function

    • Ambart Covarrubias, Macarena Aguilera-Olguín, Ivo Carrasco-Wong, Fabián Pardo, Pamela Díaz-Astudillo, Sebastián San Martín
    Pages 1-29

  3. Role of Hormones During Gestation and Early Development: Pathways Involved in Developmental Programming

    • Giselle Adriana Abruzzese, Fiorella Campo Verde Arbocco, María José Ferrer, Aimé Florencia Silva, Alicia Beatriz Motta
    Pages 31-70

  4. Physiological and Pathophysiological Role of Large-Conductance Calcium-Activated Potassium Channels (BKCa) in HUVECs and Placenta

    • Fernanda Neira, Nataly Neira, Javier Torres, Marcelo González-Ortiz
    Pages 71-82

  5. Metabolic Interaction Between Folate, Vitamin B12, and Polyunsaturated Fatty Acids in Pregnancy

    • Erika Castaño-Moreno, Ana María Ronco, Paola Casanello
    Pages 83-98

  6. Evidence of Nitric Oxide Impairment During Hypertensive Pregnancies

    • Vanessa Dela Justina, Rinaldo Rodrigues dos Passos Júnior, Victor Vitorino Lima, Fernanda Regina Giachini
    Pages 99-125

  7. Pathophysiology of Preeclampsia and L-Arginine/L-Citrulline Supplementation as a Potential Strategy to Improve Birth Outcomes

    • Tamara Ortiz-Cerda, Constanza Mosso, Ana Alcudia, Victoria Vázquez-Román, Marcelo González-Ortiz
    Pages 127-148

  8. Maternal and Fetal Expression of ATP-Binding Cassette and Solute Carrier Transporters Involved in the Brain Disposition of Drugs

    • Pablo Torres-Vergara, Robin Rivera, Carlos Escudero, Jeffrey Penny
    Pages 149-177

  9. Development of the Placenta and Brain Are Affected by Selective Serotonin Reuptake Inhibitor Exposure During Critical Periods

    • Karina Bravo, Marcelo González-Ortiz, Sebastian Beltrán-Castillo, Daniela Cáceres, Jaime Eugenín
    Pages 179-198

  10. Effects of Prenatal Cannabinoids Exposure upon Placenta and Development of Respiratory Neural Circuits

    • Daniela Cáceres, Martín Ochoa, Marcelo González-Ortiz, Karina Bravo, Jaime Eugenín
    Pages 199-232

  11. Impact of Prenatal Nicotine Exposure on Placental Function and Respiratory Neural Network Development

    • Sebastián Beltrán-Castillo, Karina Bravo, Jaime Eugenín
    Pages 233-244

  12. Language Impairment in Children of Mothers with Gestational Diabetes, Preeclampsia, and Preterm Delivery: Current Hypothesis and Potential Underlying Mechanisms

    • Yesenia Torres, Cristian Celis, Jesenia Acurio, Carlos Escudero
    Pages 245-267

  13. COVID-19 on Pregnancy Outcomes, Mental Health and Placenta: Focus in Latin America

    • Marcelo González-Ortiz, Patricio Castro, Pablo Vergara-Barra, Patricia Huerta, Carlos Escudero
    Pages 269-285

  14. The Placental Function Beyond Pregnancy: Insights from Latin America

    • Ivo Carrasco-Wong, Marcelo González-Ortiz, Gabriel Gomes Araujo, Victor V. Lima, Fernanda R. Giachini, Jana Stojanova et al.
    Pages 287-307

  15. Correction to: Advances in Maternal-Fetal Biomedicine

    • Marcelo Gonzalez-Ortiz
    Pages C1-C1

  16. Back Matter

    Pages 309-310
    Download chapter PDF
Back to top

Editors and Affiliations

  • Laboratorio de Investigación Materno-Fetal (LIMaF) Departamento de Obstetricia y Ginecología, Facultad de Medicina, Universidad de Concepción, Concepción, Chile

    Marcelo Gonzalez-Ortiz

About the editor

Marcelo González-Ortiz earned a PhD in Physiological Sciences from the Pontificia Universidad Católica de Chile in 2009. From 2009 to 2018, he led the Vascular Physiology Lab at the Department of Physiology, and since 2018, he has been the head of the Maternal-Fetal Research Lab at the Department of Obstetrics and Gynecology at the Faculty of Medicine at Universidad de Concepción in Chile. His research is focused on studying the regulation mechanisms of nitric oxide synthesis and calcium-activated potassium channels in the human placenta under both physiological and pathophysiological conditions. Currently, Dr. González-Ortiz's research projects concentrate on gestational diabetes and the effects of COVID-19 on the placenta and children.

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation