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Autophagy in Stem Cell Maintenance and Differentiation

  • Book
  • © 2023

Overview

Editors:
  1. Bhupendra V. Shravage

    1. Developmental Biology Group, Agharkar Research Institute, Pune, India

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  2. Kursad Turksen

    1. Ottawa Hospital, Ottawa, Canada

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  • Provides a comprehensive knowledge on the regulation and role of autophagy in stem cells
  • Offers insights into the mechanisms of stem-cell self-renewal and differentiation
  • Covers complex aspects of autophagy in cancer stem cells with focus on therapy

Part of the book series: Stem Cell Biology and Regenerative Medicine (STEMCELL, volume 73)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-viii
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  2. Assays for Monitoring Autophagy in Stem Cells

    • Aishwarya Chhatre, Bhupendra V. Shravage
    Pages 1-34

  3. Autophagy in Stem Cell Maintenance and Differentiation

    • Anirudha K. Sahu, Propanna Bandyopadhyay, Rajdeep Chowdhury, Sudeshna Mukherjee
    Pages 35-58

  4. Autophagy in Embryonic Stem Cells and Neural Stem Cells

    • Deepika Puri, Shalmali Bivalkar-Mehla, Deepa Subramanyam
    Pages 59-83

  5. Autophagy in Germline Stem Cells

    • Kaitlin E. Kosinski, Alicia Meléndez
    Pages 85-106

  6. The Role of Autophagy in the Regulation of Hematopoietic Stem Cells

    • Pallavi Budgude, Prajakta Teli, Anuradha Vaidya, Vaijayanti Kale
    Pages 107-135

  7. Autophagy in Muscle Stem Cells

    • Shulei Li, Romina L. Filippelli, Alice Jisoo Nam, Natasha C. Chang
    Pages 137-167

  8. Autophagy in the Intestinal Stem Cells

    • Ebru Goncu
    Pages 169-192

  9. The Autophagy Lysosomal Pathway: Friend or Foe in Adult Neural Stem Cells?

    • Isabel Calatayud-Baselga, Helena Mira
    Pages 193-217

  10. Autophagy in Mesenchymal Stem Cell-Based Therapy

    • Carl Randall Harrell, Dragica Pavlovic, Vladislav Volarevic
    Pages 219-234

  11. Autophagic Control of Stem Cells Differentiation into Osteogenic Lineage—Implications in Bone Disorders

    • Shalmoli Bhattacharyya, Aditi Mahajan
    Pages 235-257

  12. Autophagy in Cancer Metastasis

    • Ruhi Polara, Daphni van Rinsum, Nirmal Robinson
    Pages 259-285

  13. Back Matter

    Pages 287-288
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Keywords

About this book

This book covers a wide range of topics that illustrate the various functions of autophagy in stem cells and offers insights on the mechanisms by which autophagy can regulate stem-cell self-renewal and facilitate specific differentiation programs. Stem cells are unique cells present in most multicellular animals and are essential for their survival. They have two unique properties: the ability to self-renew and the ability to differentiate into one or more cell types. These characteristics of stem cells have found immense therapeutic potential in regenerative medicine. Autophagy is a crucial membrane trafficking pathway that is essential for maintaining cellular homeostasis that involves sequestration of non-functional proteins, protein aggregates and damaged organelles in double-membraned vesicles called autophagosomes, which are subsequently targeted to the lysosome for degradation. The primary aim of this book is to provide knowledge of recent developments in our understanding of the role of autophagy in stem cells, including germline stem cells.


Autophagy is considered a promising target for many diseases. Significant efforts are being developed to identify specific modulators of autophagy, which will aid in designing combinatorial therapeutic strategies that will allow significant improvements in regenerative medicine.

Editors and Affiliations

  • Developmental Biology Group, Agharkar Research Institute, Pune, India

    Bhupendra V. Shravage

  • Ottawa Hospital, Ottawa, Canada

    Kursad Turksen

Bibliographic Information

  • Book Title: Autophagy in Stem Cell Maintenance and Differentiation

  • Editors: Bhupendra V. Shravage, Kursad Turksen

  • Series Title: Stem Cell Biology and Regenerative Medicine

  • DOI: https://doi.org/10.1007/978-3-031-17362-2

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023

  • Hardcover ISBN: 978-3-031-17361-5Published: 09 November 2022

  • Softcover ISBN: 978-3-031-17364-6Published: 10 November 2023

  • eBook ISBN: 978-3-031-17362-2Published: 08 November 2022

  • Series ISSN: 2196-8985

  • Series E-ISSN: 2196-8993

  • Edition Number: 1

  • Number of Pages: VIII, 288

  • Number of Illustrations: 7 b/w illustrations, 34 illustrations in colour

  • Topics: Cancer Research, Cell Biology, Developmental Biology

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