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Evaluation of possible interaction among drugs contemplated for use during manned space flights. Part 1: Summary from progress report dated 31 October 1973. Part 2: Progress report for the period November 1973 to June 1974Possible interactions among drugs contemplated for use during manned spaceflights have been studied in several animal species. The following seven drugs were investigated: nitrofurantoin, chloral hydrate, hexobarbital, phenobarbital, flurazepam, diphenoxylate, and phenazopyridine. Particular combinations included: chloral hydrate, hexobarbital or flurazepam with nitrofurantoin; phenobarbital or flurazepam with phenazopyridine; and diphenoxylate with two dose formulations of nitrofurantoin. The mechanism of action and an explanation of the interaction between diphenoxylate and nitrofurantoin still remains unclear. In man, the interaction does not appear to be significant, affecting only two subjects out of six and with only one dose formulation (Furadantin).
Document ID
19740024423
Acquisition Source
Legacy CDMS
Document Type
Contractor Report (CR)
Date Acquired
September 3, 2013
Publication Date
July 31, 1974
Subject Category
Biosciences
Report/Patent Number
NASA-CR-140245
C-74804-PT-2
C-74804-PT-1
Accession Number
74N32536
Funding Number(s)
CONTRACT_GRANT: NAS9-12970
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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