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Effect of dichloromethane on the sciatic motor conduction velocity of rats

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Summary

There is a correlation between dichloromethane dosis (X) of 1–6 mmole/kg administered i.p. to rats and the sciatic motor conduction velocity (Y): Y=57.1−1.091 X. The correlation coefficient ‘r’ is 0.437 (p<0.01). Presumably, the decrease of nerve conduction velocity is caused by the endogenous carbon monoxide production due to dichloromethane biotransformation.

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Authors and Affiliations

  1. Lehrstuhl für Industrietoxikologie am Hygiene-Institut und Klinik und Poliklinik für Psychiatrie und Neurologie der Martin-Luther-Universität, Leninallee 4, DDR-402, Halle a.d. Saale, Germany

    D. Pankow, R. Gutewort, W. Ponsold, W. Glatzel & K. Tietze

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  1. D. Pankow
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  2. R. Gutewort
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  3. W. Ponsold
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  4. W. Glatzel
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  5. K. Tietze
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Pankow, D., Gutewort, R., Ponsold, W. et al. Effect of dichloromethane on the sciatic motor conduction velocity of rats. Experientia 35, 373–374 (1979). https://doi.org/10.1007/BF01964361

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