Abstract
Trisodium phosphonoformate selectively inhibits cell-free DNA polymerase activity induced by herpesvirus. The new inhibitor has an antiviral effect on herpes simplex virus types 1 and 2, pseudorables virus, and infectious bovine rhinotracheitis virus in cell culture. It has a good therapeutic activity against cutaneous herpes simplex virus infection in guinea pigs.
MeSH terms
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Animals
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Antiviral Agents* / therapeutic use
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Antiviral Agents* / toxicity
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Cell Line
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DNA-Directed RNA Polymerases / antagonists & inhibitors*
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Formates / pharmacology
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Formates / toxicity
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Guinea Pigs
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Herpesviridae Infections / drug therapy
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Nucleic Acid Synthesis Inhibitors*
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Organophosphorus Compounds / pharmacology*
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Organophosphorus Compounds / toxicity
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Phosphonoacetic Acid / pharmacology
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Simplexvirus / enzymology
Substances
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Antiviral Agents
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Formates
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Nucleic Acid Synthesis Inhibitors
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Organophosphorus Compounds
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DNA-Directed RNA Polymerases
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Phosphonoacetic Acid