Publication Date:
2014-08-03
Description:
Article Loss of cell polarity is frequently observed in metastatic tumours. Mojallal et al. show that this loss is associated with expression of the scaffold protein AmotL2 in human tumours, and reveal that AmotL2 disrupts the transport of polarity complexes to the plasma membrane following its induction by hypoxia. Nature Communications doi: 10.1038/ncomms5557 Authors: Mahdi Mojallal, Yujuan Zheng, Sara Hultin, Stéphane Audebert, Tanja van Harn, Per Johnsson, Claes Lenander, Nicolas Fritz, Christin Mieth, Martin Corcoran, Frédérique Lembo, Marja Hallström, Johan Hartman, Nathalie M. Mazure, Thomas Weide, Dan Grandér, Jean-Paul Borg, Per Uhlén, Lars Holmgren
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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