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  • Springer  (10)
  • Wiley-Blackwell  (1)
  • American Chemical Society (ACS)
  • 1995-1999  (6)
  • 1985-1989  (3)
  • 1975-1979  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Hb Costa Rica or α2β277(EF1)His→Arg: The first example of a somatic cell mutation in a globin gene (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 829-833 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have identified a minor hemoglobin component (∼5%) in the blood of a healthy Costa Rican female, but not in her mother and two brothers (father not studied), that has an His→Arg replacement at position β77 (Hb Costa Rica). No other amino acid replacements were observed and no β- or γ-chain-like peptides were present. Hb Costa Rica has a normal stability. Sequence analyses of numerous polymerase chain reaction (PCR)-amplified segments of DNA that contain exon 2 of the β gene failed to identify a CAC→WGC (His→Arg) mutation. The same was the case when cDNA was sequenced, indicating that a β-Costa Rica-mRNA could not be detected with this procedure. Gene mapping of genomic DNA withBglII,BamHI, andHindIII gave normal fragments only and with the same intensity as observed for the fragments of a normal control. The quantities of the β chain variants Hb JIran and Hb Fukuyama with related mutations at (β77 vary between 30% and 45% in heterozygotes, whereas that of Hb F-Kennestone with the same His→Arg mutation but in theGyγ-globin gene, is a high 40%–45% (as percentage of totalGγ) in a heterozygous newborn. These different observations exclude a heterozygosity of the A→G mutation at codon β77, as well as a deletion comparable to that of Hbs Lepore or Kenya, or a β-globin gene duplication, and point to a nontraditional inheritance of Hb Costa Rica. Allele-specific amplification of cDNA with appropriate primers identified the presence of a low level of mutated mRNA in the reticulocytes of the patient, which was confirmed by dotblot analysis of the same material with32p-labeled probes. Comparable amplification products were not observed in genomic DNA. The A→G mutation apparently occurred in a somatic cell at a relatively early stage in the development of the hematopoietic cell system, and Hb Costa Rica accumulated through rapid cell divisions in patchy areas in the bone marrow (somatic mosaicism). An unequal distribution of Hb Costa Rica over the red cells supports this possibility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02346198
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  • 2
    Electronic Resource
    Electronic Resource
    Hb Costa Rica or · 2 ‚ 277(EF1)His→Arg: the first example of a somatic cell mutation in a globin gene (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 829-833 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have identified a minor hemoglobin component (∼5%) in the blood of a healthy Costa Rican female, but not in her mother and two brothers (father not studied), that has an His→Arg replacement at position β77 (Hb Costa Rica). No other amino acid replacements were observed and no β- or γ-chain-like peptides were present. Hb Costa Rica has a normal stability. Sequence analyses of numerous polymerase chain reaction (PCR)-amplified segments of DNA that contain exon 2 of the β gene failed to identify a CAC→CGC (His→Arg) mutation. The same was the case when cDNA was sequenced, indicating that a β-Costa Rica-mRNA could not be detected with this procedure. Gene mapping of genomic DNA with BglII, BamHI, and HindIII gave normal fragments only and with the same intensity as observed for the fragments of a normal control. The quantities of the β chain variants Hb J-Iran and Hb Fukuyama with related mutations at β77 vary between 30% and 45% in heterozygotes, whereas that of Hb F-Kennestone with the same His→Arg mutation but in the Gγ-globin gene, is a high 40%–45% (as percentage of total Gγ) in a heterozygous newborn. These different observations exclude a heterozygosity of the A→G mutation at codon β77, as well as a deletion comparable to that of Hbs Lepore or Kenya, or a β-globin gene duplication, and point to a nontraditional inheritance of Hb Costa Rica. Allele-specific amplification of cDNA with appropriate primers identified the presence of a low level of mutated mRNA in the reticulocytes of the patient, which was confirmed by dotblot analysis of the same material with 32P-labeled probes. Comparable amplification products were not observed in genomic DNA. The A→G mutation apparently occurred in a somatic cell at a relatively early stage in the development of the hematopoietic cell system, and Hb Costa Rica accumulated through rapid cell divisions in patchy areas in the bone marrow (somatic mosaicism). An unequal distribution of Hb Costa Rica over the red cells supports this possibility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050145
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  • 3
    Electronic Resource
    Electronic Resource
    Utilization of benzodiazepines in Chile during 1982–1986 (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 139-143 
    Details
    ISSN: 1432-1041
    Keywords: benzodiazepine ; Chile ; agent consumption/ — utilization ; diazepam ; flunitrazepam
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The consumption of benzodiazepine drugs (BDZ) in Chile in the period 1982–1986 has been studied by the DDD method. National use was assessed using drug import forms as a source of information, assuming that the total amount imported was manufactured and consumed in the same year. The utilization did not show a constant pattern, being 32.7, 33.6, 50.2, 34.9, and 31.3 DDD 1000 per inhabitants per day in 1982, 1983, 1984, 1985 and 1986, respectively. During the study period, diazepam was the most commonly used agent amongst anxiolytic BDZ, reaching a peak of 27.1 DDD per 1000 inhabitants per day in 1984, and flunitrazepam was the most popular hypnotic, attaining its maximum in 1986 (6.4 DDD per 1000 inhabitants per day). The use of BDZ at community pharmacy level was also evaluated, employing the International Marketing System (IMS) as the source of information. At that level the pattern of utilization showed a constant increase during the study period, being 14.9 and 25.8 DDD/1000 inhabitants/per day in 1982 and 1986, respectively. In community pharmacies the anxiolytic BDZ most often consumed was diazepam (maximum 9.1 DDD per 1000 inhabitants per day in 1985), and the commonest hypnotic was flunitrazepam (peak 6.0 DDD per 1000 inhabitants per day in 1986). National consumption of BDZ appeared higher and more variable than use at the community pharmacy level, but in both there was greater usage of anxiolytic than of hypnotic BDZ, and diazepam and flunitrazepam were the most popular agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558221
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of phosphate omission on glucose-induced insulin release in vitro (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 1260-1261 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In the isolated perfused rat pancreas, omission of extracellular phosphate (H2PO 4 − significantly reduces the insulin secretion in response to 16.7 mM glucose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01963326
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  • 5
    Electronic Resource
    Electronic Resource
    Self-focusing in photorefractive BaTiO3 crystal under external DC electric field (1998)
    Springer
    Optical and quantum electronics 30 (1998), S. 829-834 
    Details
    ISSN: 1572-817X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: Abstract Experimental observations of 1D and 2D self-focusing in a BaTiO3 crystal under externally DC applied electric field are reported. Stationary self-focusing behaviour can be obtained with and without additional uniform illumination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006930624765
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  • 6
    Electronic Resource
    Electronic Resource
    Three-Parameter Corresponding-States Correlations for Joule–Thomson Inversion Curves (1999)
    Springer
    International journal of thermophysics 20 (1999), S. 1737-1751 
    Details
    ISSN: 1572-9567
    Keywords: correlation ; corresponding-states ; inversion curve ; Joule–Thomson
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract In the present work, the Lee–Kesler (LK) and Boublík–Alder–Chen–Kreglewski (BACK) equations of state were used to compute Joule–Thomson inversion curves for nonsimple fluids. Comparisons with available data showed that predictions were quite reliable and could be used in place of experimental values. Two sets of corresponding-states correlations were developed, giving reduced inversion pressures and densities as functions of reduced temperature and acentric factor. The LK-based correlations are valid for T r≤4.0, giving an average absolute deviation (AAD) of 4.5% for pressures. The BACK-based correlations are valid up to the maximum inversion temperature and give a 6.7% AAD for pressures. Respective volume AADs are 12.0 and 8.0% in the high-density region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022662030434
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  • 7
    Electronic Resource
    Electronic Resource
    Postirradiation polymerization of vinyl monomers on poly(ethylene terephthalate) (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 31 (1986), S. 509-519 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A postirradiation process was evaluated in polymerizing vinyl monomers on poly(ethylene terephthalate) (PET) film, fiber, and fabric. The use of DMF, pyridine, and DMSO as swelling agents to facilitate monomer incorporation and effective polymerization were also investigated. The solvents were effective in promoting the incorporation of acrylic acid (AA) in PET film and that of n-vinyl-2-pyrrolidinone (VP) in Dacron 54. AA, a good swelling agent for PET, produced equivalent polymerization yield and moisture regain results with or without any solvent on Dacron 54 and 64. Polymerization yields on films increased with increasing total doses, but those on yarns and fabrics were independent of total dose. The different results obtained on film versus yarn and fabric from solvent treatment and total dose is thought to be due to the different surface-volume ratio of these substrates. The moisture properties of the substrates were dependent mainly upon the monomer type. Among the monomers studied, VP gave highest moisture regain values, followed by AA. The tensile properties of the modified Dacron 54 were not affected. However the breaking elongation of the modified Dacron 64 was slightly lowered by postirradiation polymerization without solvent treatment and was increased when solvent treatment was included.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1986.070310218
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  • 8
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    Effect of phosphate omission on glucose-induced insulin release in vitro (1979)
    Springer
    Details
    Publication Date: 1979-09-01
    Print ISSN: 0014-4754
    Topics: Biology , Medicine
    Published by Springer
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  • 9
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    Utilization of benzodiazepines in Chile during 1982?1986 (1989)
    Springer
    Details
    Publication Date: 1989-01-01
    Print ISSN: 0031-6970
    Electronic ISSN: 1432-1041
    Topics: Chemistry and Pharmacology , Medicine
    Published by Springer
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  • 10
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    Hb Costa Rica or α2β277(EF1)His→Arg: The first example of a somatic cell mutation in a globin gene (1996)
    Springer
    Details
    Publication Date: 1996-06-01
    Print ISSN: 0340-6717
    Electronic ISSN: 1432-1203
    Topics: Biology , Medicine
    Published by Springer
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