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  • 1
    Description / Table of Contents: The supercontinent-cycle hypothesis attributes planetary-scale episodic tectonic events to an intrinsic self-organizing mode of mantle convection, governed by the buoyancy of continental lithosphere that resists subduction during the closure of old ocean basins, and the consequent reorganization of mantle convection cells leading to the opening of new ocean basins. Characteristic timescales of the cycle are typically 500 to 700 million years. Proposed spatial patterns of cyclicity range from hemispheric (introversion) to antipodal (extroversion), to precisely between those end members (orthoversion). Advances in our understanding can arise from theoretical or numerical modelling, primary data acquisition relevant to continental reconstructions, and spatiotemporal correlations between plate kinematics, geodynamic events and palaeoenvironmental history. The palaeogeographic record of supercontinental tectonics on Earth is still under development. The contributions in this Special Publication provide snapshots in time of these investigations and indicate that Earth's palaeogeographic record incorporates elements of all three end-member spatial patterns.
    Pages: Online-Ressource (297 Seiten)
    ISBN: 9781862397330
    Language: English
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  • 2
    Publication Date: 2015-08-05
    Description: By adjusting the focus geometry of a spatially structured laser pulse, single, double, and treble quasi-monoenergetic electron beams were generated, respectively, in laser-wakefield acceleration. Single electron beam was produced as focusing the laser pulse to a single spot. While focusing the laser pulse to two spots that are approximately equal in energy and size and intense enough to form their own filaments, two electron beams were produced. Moreover, with a proper distance between those two focal spots, three electron beams emerged with a certain probability owing to the superposition of the diffractions of those two spots. The energy spectra of the multiple electron beams are quasi-monoenergetic, which are different from that of the large energy spread beams produced due to the longitudinal multiple-injection in the single bubble.
    Print ISSN: 1070-664X
    Electronic ISSN: 1089-7674
    Topics: Physics
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  • 3
    Publication Date: 2014-08-08
    Description: In order to validate the accuracy of estimated Green’s functions (EGFs), which are widely used in ambient seismic noise tomography, a broadband seismograph was installed in the epicentral area of an M  5 earthquake, with ground-truth location from Interferometric Synthetic Aperture Radar observations. EGFs between this station and permanent stations are compared with surface waves excited by the earthquake. The group velocity dispersion measured from EGFs at large interstation distances (~1000 km or longer) are consistent with measurements from the earthquake, and the EGFs from symmetric noise correlation functions (NCFs) are usually more accurate. At shorter interstation distances (300–1000 km), the match between noise and earthquake dispersion is good for most stations, although we observed mismatch for a few stations. The mismatch is probably caused by low signal-to-noise ratio of NCFs or nondiffusive noise wavefield at short distances. Online Material: Figure showing mismatch of group velocity dispersion between earthquake and noise data, and figure of phase velocity dispersion between earthquake data and noise correlation functions at station ENH.
    Print ISSN: 0037-1106
    Electronic ISSN: 1943-3573
    Topics: Geosciences , Physics
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  • 4
    Publication Date: 2016-03-11
    Description: MiR-125a-5p decreases after long non-coding RNA HOTAIR knockdown to promote cancer cell apoptosis by releasing caspase 2 Cell Death and Disease 7, e2137 (March 2016). doi:10.1038/cddis.2016.41 Authors: L Tang, H Shen, X Li, Z Li, Z Liu, J Xu, S Ma, X Zhao, X Bai, M Li, Q Wang & J Ji
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 5
    Publication Date: 2017-11-01
    Description: Multiples are usually regarded as noise in conventional seismic data processing. However, multiples are also real reflections from structural interfaces in the subsurface. Compared with primaries, multiples usually provide more balanced illumination and contain more structural information because of the smaller reflection angles and longer wavepaths. Instead of multiple suppression, multiple imaging has attracted increasingly more attention in recent years. The most commonly used migration method for multiples is performed by replacing the source wavelet with recorded data and using separated multiples as the receiver record. Then, the image of the multiples is obtained by the application of the crosscorrelation imaging condition, which is widely used in conventional migration. However, during the imaging procedure, events are matched based on their propagation times only. Crosscorrelation of unrelated events leads to heavy crosstalk, and image artifacts are introduced in the image of multiples. To overcome this shortcoming, we have introduced the stereographic imaging condition for the one-way wave-equation migration of multiples. By adding a local-slope constraint (the local slope of the extrapolated wavefields at every position and time), the stereographic imaging condition takes the local spatial coherence of the extrapolated wavefields into account. Events can be matched based not only on the propagating times but also the local slopes. Therefore, crosstalk artifacts caused by the interference of unrelated events can be efficiently suppressed. Furthermore, to improve the computational accuracy and efficiency of our approach, plane-wave destructors are introduced to estimate the reflector slopes. In this way, the need for excessive loops over the local slopes in the x - z domain during application of the stereographic imaging condition can be avoided by selecting the local slopes in a proper range. Better migration results of multiples are obtained in numerical tests, which verify the feasibility and effectiveness of our approach.
    Print ISSN: 0016-8033
    Electronic ISSN: 1942-2156
    Topics: Geosciences , Physics
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  • 6
    Publication Date: 2015-08-12
    Description: The empirical criteria for defining a clinical subtype of lung cancer are gradually transiting from histopathology to genetic variations in driver genes. Targeting these driver mutations, such as sensitizing epidermal growth factor receptor (EGFR) mutations, has dramatically improved the prognosis of advanced non–small cell lung cancer (NSCLC). However, the clinical...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 7
    Publication Date: 2015-08-15
    Description: Using an in situ electrical method and the multi-anvil apparatus, we determined the melting curve of sodium chloride (NaC1) up to ~20 GPa, with an estimated uncertainty of ±40 K. Our results agree well with the existing data up to 6.5 GPa. At higher pressures, the melting temperatures from this study are as much as 200 K higher than those from an experimental study using the diamond-anvil cell (DAC), and are up to 500 K lower than those from theoretical studies using molecular dynamics (MD). The discrepancies may originate from surface melting in the DAC measurements, which underestimate the melting temperature, and from superheating in MD calculations, which over-predict the melting temperature. Fitting our results to the Simon equation yield ( T / T 0 ) 4.5 = ( P – P 0 )/0.6 + 1, where T and T 0 are the melting temperatures at P and P 0 , respectively, with T 0 = 1073.6 K, T in K and P in GPa. The Simon equation fits the experimental data within uncertainties and therefore can be used to interpolate the melting curve. Using the equation of state (EoS) of NaCl at 300 K, the results are fitted to the Kraut-Kennedy equation in the form of T / T 0 = ( V 0 – V )/ V 0 ·4.37 + 1, where T (in K) and T 0 (= 1073.6 K) are the melting temperatures at V and V 0 (at 0.0001 GPa), respectively. At pressures above 14 GPa, the experimental data deviate from the Kraut-Kennedy equation fit toward lower temperatures, probably because the volume dependence of the Grüneisen parameter was ignored in the equation. The Gilvarry-Lindemann equation T m ~ 1.689· f 2 · 0 2 · ( V 0 / V ) 2(–1/3) provides a satisfactory fit to the melting curve of NaCl between 0 and 19 GPa if the exponent q in the volume dependence of the Grüneisen parameter = 0 · ( V/V 0 ) q is allowed to deviate from one. Given that the melting curve of NaCl up to 6.5 GPa is well established, monitoring the melting of NaCl offers an efficient alternative for pressure calibration of large-volume high-pressure apparatus for Earth science applications.
    Print ISSN: 0003-004X
    Electronic ISSN: 1945-3027
    Topics: Geosciences
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  • 8
    Publication Date: 2013-09-13
    Description: Overexpression of 4EBP1, p70S6K, Akt1 or Akt2 differentially promotes Coxsackievirus B3-induced apoptosis in HeLa cells Cell Death and Disease 4, e803 (September 2013). doi:10.1038/cddis.2013.331 Authors: X Li, Z Li, W Zhou, X Xing, L Huang, L Tian, J Chen, C Chen, X Ma & Z Yang
    Keywords: overexpression4EBP1p70S6KAktcoxsackievirus b3apoptosis
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 9
    Publication Date: 2015-05-03
    Description: Growth arrest and DNA-damage-inducible protein 45 (Gadd45) family members have been implicated in DNA demethylation in vertebrates. However, it remained unclear how they contribute to the demethylation process. Here, we demonstrate that Gadd45a promotes active DNA demethylation through thymine DNA glycosylase (TDG) which has recently been shown to excise 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) generated in Ten-eleven-translocation (Tet)—initiated oxidative demethylation. The connection of Gadd45a with oxidative demethylation is evidenced by the enhanced activation of a methylated reporter gene in HEK293T cells expressing Gadd45a in combination with catalytically active TDG and Tet. Gadd45a interacts with TDG physically and increases the removal of 5fC and 5caC from genomic and transfected plasmid DNA by TDG. Knockout of both Gadd45a and Gadd45b from mouse ES cells leads to hypermethylation of specific genomic loci most of which are also targets of TDG and show 5fC enrichment in TDG-deficient cells. These observations indicate that the demethylation effect of Gadd45a is mediated by TDG activity. This finding thus unites Gadd45a with the recently defined Tet-initiated demethylation pathway.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 10
    Publication Date: 2019
    Description: 〈p〉Sickle cell disease is induced by a mutation that converts normal adult hemoglobin to sickle hemoglobin (HbS) and engenders intracellular polymerization of deoxy-HbS and erythrocyte sickling. Development of anti-sickling therapies requires quantitative understanding of HbS polymerization kinetics under organ-specific conditions, which are difficult to assess with existing experimental techniques. Thus, we developed a kinetic model based on the classical nucleation theory to examine the effectiveness of potential anti-sickling drug candidates. We validated this model by comparing its predictability against prior in vivo and in vitro experimental results. We used the model to quantify the efficacy of sickling inhibitors and obtain results consistent with recent screening assays. Global sensitivity analysis on the kinetic parameters in the model revealed that the solubility, nucleation rate prefactor, and oxygen affinity are quantities that dictate HbS polymerization. This finding provides quantitative guidelines for the discovery of intracellular processes to be targeted by sickling inhibitors.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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