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  • 1
    Keywords: Pharmaceutical chemistry. ; Pharmacology. ; Clinical biochemistry. ; Pharmaceutics. ; Pharmacology. ; Medical Biochemistry.
    Description / Table of Contents: Route-Specific Challenges in the Delivery of Poorly Water-Soluble Drugs -- Optimizing the Formulation of Poorly Water-Soluble Drugs -- Solid-State Techniques for Improving Solubility -- Mechanical Particle-Size Reduction Techniques -- Co-solvent and Complexation Systems -- Injectable Formulations of Poorly Water-Soluble Drugs -- Lipid-Based Formulations -- Structured Development Approach for Amorphous Systems -- Melt Extrusion -- Spray-Drying Technology -- Pharmaceutical Cryogenic Technologies -- Precipitation Technologies for Nanoparticle Production -- Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs -- Scientific and Regulatory Considerations for Development and Commercialization of Poorly Water-Soluble Drugs.
    Abstract: The objective of this third edition is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at a minimum a working knowledge of each of the above mentioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop. Highlights the most recent advancements reported in the literature on technologies to improve the dissolution and bioavailability of poorly water soluble drugs Provides a comprehensive discussion of new technologies developed and recently over 40% updated new content Essential read for scientists and researchers in pharmaceutical, chemical, and agricultural industries since over 80% of newly discovered drugs are poorly water soluble.
    Type of Medium: Online Resource
    Pages: XII, 693 p. 280 illus., 138 illus. in color. , online resource.
    Edition: 3rd ed. 2022.
    ISBN: 9783030887193
    Series Statement: AAPS Advances in the Pharmaceutical Sciences Series, 50
    DDC: 615.19
    Language: English
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  • 2
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Environmental sciences Social aspects. ; Human geography. ; Cultural geography. ; Cultural property. ; Sociology, Urban. ; Environmental Social Sciences. ; Social and Cultural Geography. ; Cultural Heritage. ; Urban Sociology.
    Description / Table of Contents: Chapter 01 Rural Sustainability: challenges and opportunities -- Chapter 02 Case study: Rural revitalization in Hong Kong -- Chapter 03 Rural Sustainability: six core dimensions -- Chapter 04 Conclusion and the future of rural communities.
    Abstract: This book highlights the challenges and opportunities of (re)constructing a sustainable rural community on the outskirts of the urban community. Based on knowledge and experience accumulated through implementing a rural revitalisation project in Hong Kong since 2013, the book provides an in-depth analysis of a case study along with related concepts from the literature. In particular, the concept of rural resilience is broken down and used to examine how communities at the urban-rural interface can leverage their position and connections to (re)create vibrant sustainable communities. The revitalisation project was showcased in the databases of the United Nations Development Programme (UNDP)’s Equator Initiative and the International Partnership for the Satoyama Initiative (IPSI) as well as achieving Special Recognition for Sustainable Development in the UNESCO Asia-Pacific Awards for Cultural Heritage Conservation in 2020. This book teases out the key issues in the process of revitalising a rural community in the peri-urban context and examines the complexities embedded in each issue and how they can be addressed in the quest for rural sustainability.
    Type of Medium: Online Resource
    Pages: IX, 94 p. 5 illus., 3 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811658242
    Series Statement: SpringerBriefs on Case Studies of Sustainable Development,
    DDC: 304.2
    Language: English
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  • 3
    Keywords: Earth sciences. ; Geography. ; Sustainability. ; Renewable energy sources. ; Environmental management. ; Schools of economics. ; Economic policy. ; Earth and Environmental Sciences. ; Sustainability. ; Renewable Energy. ; Environmental Management. ; Heterodox Economics. ; Economic Policy.
    Description / Table of Contents: Introduction by William Rees -- Ch 1: The great acceleration, planetary boundaries and the Anthropocene, Will Steffen, Ch 2: Assessing natural environments: a summary, David Lindenmayer & Chris Dickman -- Ch 3: Human health and the natural environment, Colin D. Butler -- Ch 4:UN Sustainability Goals, Kerryn Higgs -- Ch. 5: The evolution of neoliberalism, John Quiggin -- Ch 6: Population growth, Ian Lowe -- Ch 7: Evaluation ‘The Limits to Growth’ 50 Years On, Kerryn Higgs -- Ch 8: The role of the fossil fuel industry, Ian Dunlop -- Ch 9: Economic failures of the IPCC process, Steve Keen -- Ch 10: Introduction to ecological economics, Philip Lawn & Stephen Williams -- Ch 11: Energy systems for sustainable prosperity, Mark Diesendorf -- Ch 12: Climate litigation and human rights, Michael Kirby & Sean Ryan -- Ch 13: What is a green deal without growth, Riccardo Mastini -- Ch 14: Paying a Green New Deal: MMT and the job guarantee, Steven Hall -- Ch 15: The Paradigm Shift, Stephen Williams -- Appendix.
    Abstract: This multidisciplinary book provides new insights and hope for sustainable prosperity given recent developments in economics – but only if swift and strong actions consistent with Earth’s biophysical limits and principles of justice are universally taken. It is one thing to put limits on resource throughput and waste generation to conform with the ecosphere’s biocapacity. It is another thing to efficiently allocate a sustainable rate of resource throughput and ensure it is equitably distributed in the form of final goods and services. While the separate but interdependent decisions regarding throughput, distribution, and allocation are the essence of ecological economics, dealing with them in a world that needs to cure its growth addiction requires a realistic understanding of macroeconomics and the fiscal capacity of currency-issuing central governments. Sustainable prosperity demands that we harness this understanding to carefully regulate the rate of resource throughput and manipulate macroeconomic outcomes to facilitate human flourishing. The book begins by outlining humanity’s current predicament of gross ecological overshoot and laments the half-century of missed opportunities since The Limits to Growth (1972). What was once economic growth has become, in many high-income countries, uneconomic growth (additional costs exceeding additional benefits), which is no longer advancing wellbeing. Meanwhile, low-income nations need a dose of efficient and equitable growth to escape poverty while protecting their environments and the global commons. The book argues for a synthesis of our increasing knowledge of the ecosphere’s limited carrying capacity and the power of governments to harness, transform, and distribute resources for the common good. Central to this synthesis must be a correct understanding of the difference between financial constraints and real resource constraints. While the latter apply to everyone, the former do not apply to currency-issuing central governments, which have much more capacity for corrective action than mainstream thinking perceives. The book joins the growing chorus of authoritative voices calling for a complete overhaul of the dominant economic system. We conclude with policy recommendations based on a new economics that, if implemented, would come close to guaranteeing a sustainable and prosperous future. Upon reading this book, at least one thing should be crystal clear: business as usual is not a viable option.
    Type of Medium: Online Resource
    Pages: VIII, 344 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030787950
    DDC: 500
    Language: English
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  • 4
    Series available for loan
    Series available for loan
    Ottawa : Geological Survey of Canada
    Associated volumes
    Call number: SR 90.0008(70-65)
    In: Paper
    Type of Medium: Series available for loan
    Pages: V, 39 S. + 1 pl.
    Series Statement: Paper / Geological Survey of Canada 70-65
    Language: English
    Location: Lower compact magazine
    Branch Library: GFZ Library
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  • 5
    Series available for loan
    Series available for loan
    Ottawa : Geological Survey of Canada
    Associated volumes
    Call number: SR 90.0008(74-62)
    In: Paper
    Type of Medium: Series available for loan
    Pages: 14 S. + 2 pl.
    Series Statement: Paper / Geological Survey of Canada 74-62
    Language: English
    Location: Lower compact magazine
    Branch Library: GFZ Library
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  • 6
    Series available for loan
    Series available for loan
    Ottawa : Geological Survey of Canada
    Associated volumes
    Call number: SR 90.0008(73-26)
    In: Paper
    Type of Medium: Series available for loan
    Pages: 25 S.
    Series Statement: Paper / Geological Survey of Canada 73-26
    Language: English
    Location: Lower compact magazine
    Branch Library: GFZ Library
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  • 7
    Series available for loan
    Series available for loan
    Canberra : Australian Gov. Publ. Service
    Associated volumes
    Call number: SR 93.0764(23)
    In: Report
    Type of Medium: Series available for loan
    Pages: V, 8 S.
    Series Statement: Report / Commonwealth of Australia, Department of National Development, Bureau of Mineral Resources, Geology and Geophysics 23
    Language: English
    Location: Lower compact magazine
    Branch Library: GFZ Library
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  • 8
    Call number: 14920
    Type of Medium: Monograph available for loan
    Pages: XIX, 308 S.
    ISBN: 3528046392
    Uniform Title: OS 2, features, functions and applications
    Language: German
    Location: Upper compact magazine
    Branch Library: GFZ Library
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  • 9
    Series available for loan
    Series available for loan
    Ottawa : Geological Survey of Canada
    Associated volumes
    Call number: SR 90.0008(72-34)
    In: Paper
    Type of Medium: Series available for loan
    Pages: 7 S. + 1 pl.
    Series Statement: Paper / Geological Survey of Canada 72-34
    Language: English
    Location: Lower compact magazine
    Branch Library: GFZ Library
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  • 10
    Series available for loan
    Series available for loan
    Ottawa : Geological Survey of Canada
    Associated volumes
    Call number: SR 90.0008(74-50)
    In: Paper
    Type of Medium: Series available for loan
    Pages: 12 S. + 1 pl.
    Series Statement: Paper / Geological Survey of Canada 74-50
    Language: English
    Location: Lower compact magazine
    Branch Library: GFZ Library
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