ALBERT

Description: Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide variation from this region remain largely uncharacterized. We studied genomic variation within Mexico from over 1000 individuals representing 20 indigenous and 11 mestizo populations. We found striking genetic stratification among indigenous populations within Mexico at varying degrees of geographic isolation. Some groups were as differentiated as Europeans are from East Asians. Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country. Furthermore, two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between subcontinental ancestry and lung function. Thus, accounting for fine-scale ancestry patterns is critical for medical and population genetic studies within Mexico, in Mexican-descent populations, and likely in many other populations worldwide.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156478/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156478/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moreno-Estrada, Andres -- Gignoux, Christopher R -- Fernandez-Lopez, Juan Carlos -- Zakharia, Fouad -- Sikora, Martin -- Contreras, Alejandra V -- Acuna-Alonzo, Victor -- Sandoval, Karla -- Eng, Celeste -- Romero-Hidalgo, Sandra -- Ortiz-Tello, Patricia -- Robles, Victoria -- Kenny, Eimear E -- Nuno-Arana, Ismael -- Barquera-Lozano, Rodrigo -- Macin-Perez, Gaston -- Granados-Arriola, Julio -- Huntsman, Scott -- Galanter, Joshua M -- Via, Marc -- Ford, Jean G -- Chapela, Rocio -- Rodriguez-Cintron, William -- Rodriguez-Santana, Jose R -- Romieu, Isabelle -- Sienra-Monge, Juan Jose -- del Rio Navarro, Blanca -- London, Stephanie J -- Ruiz-Linares, Andres -- Garcia-Herrera, Rodrigo -- Estrada, Karol -- Hidalgo-Miranda, Alfredo -- Jimenez-Sanchez, Gerardo -- Carnevale, Alessandra -- Soberon, Xavier -- Canizales-Quinteros, Samuel -- Rangel-Villalobos, Hector -- Silva-Zolezzi, Irma -- Burchard, Esteban Gonzalez -- Bustamante, Carlos D -- BB/I021213/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- ES015794/ES/NIEHS NIH HHS/ -- GM007546/GM/NIGMS NIH HHS/ -- GM061390/GM/NIGMS NIH HHS/ -- HL004464/HL/NHLBI NIH HHS/ -- HL078885/HL/NHLBI NIH HHS/ -- HL088133/HL/NHLBI NIH HHS/ -- HL111636/HL/NHLBI NIH HHS/ -- K23 HL004464/HL/NHLBI NIH HHS/ -- K23 HL111636/HL/NHLBI NIH HHS/ -- M01 RR000083/RR/NCRR NIH HHS/ -- P60 MD006902/MD/NIMHD NIH HHS/ -- P60MD006902/MD/NIMHD NIH HHS/ -- R01 ES015794/ES/NIEHS NIH HHS/ -- R01 GM083606/GM/NIGMS NIH HHS/ -- R01 GM090087/GM/NIGMS NIH HHS/ -- R01 HG003229/HG/NHGRI NIH HHS/ -- R01 HL078885/HL/NHLBI NIH HHS/ -- R01 HL088133/HL/NHLBI NIH HHS/ -- R01GM090087/GM/NIGMS NIH HHS/ -- R01HG003229/HG/NHGRI NIH HHS/ -- R13 MD008154/MD/NIMHD NIH HHS/ -- RR000083/RR/NCRR NIH HHS/ -- T32 GM007175/GM/NIGMS NIH HHS/ -- T32 GM007546/GM/NIGMS NIH HHS/ -- T32 HG000044/HG/NHGRI NIH HHS/ -- T32GM007175/GM/NIGMS NIH HHS/ -- T32HG000044/HG/NHGRI NIH HHS/ -- U01 GM061390/GM/NIGMS NIH HHS/ -- ZIA ES049019-14/Intramural NIH HHS/ -- ZIA ES049019-15/Intramural NIH HHS/ -- ZIA ES49019/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 2014 Jun 13;344(6189):1280-5. doi: 10.1126/science.1251688. Epub 2014 Jun 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. cdbustam@stanford.edu morenoe@stanford.edu esteban.burchard@ucsf.edu. ; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA. cdbustam@stanford.edu morenoe@stanford.edu esteban.burchard@ucsf.edu. ; Instituto Nacional de Medicina Genomica (INMEGEN), Mexico City, Mexico. ; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. ; Escuela Nacional de Antropologia e Historia (ENAH), Mexico City, Mexico. Department of Genetics, Evolution and Environment, University College London, London, UK. ; Department of Medicine, University of California, San Francisco, CA, USA. ; Instituto de Investigacion en Genetica Molecular, Universidad de Guadalajara, Ocotlan, Mexico. ; Escuela Nacional de Antropologia e Historia (ENAH), Mexico City, Mexico. ; Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico. ; Department of Medicine, University of California, San Francisco, CA, USA. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA. ; The Brooklyn Hospital Center, Brooklyn, NY, USA. ; Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico. ; Veterans Caribbean Health Care System, San Juan, Puerto Rico. ; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. Instituto Nacional de Medicina Genomica (INMEGEN), Mexico City, Mexico. ; International Agency for Research on Cancer, Lyon, France. ; Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico. ; National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA. ; Department of Genetics, Evolution and Environment, University College London, London, UK. ; Instituto Nacional de Medicina Genomica (INMEGEN), Mexico City, Mexico. Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico. ; Department of Medicine, University of California, San Francisco, CA, USA. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA. cdbustam@stanford.edu morenoe@stanford.edu esteban.burchard@ucsf.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24926019" target="_blank"〉PubMed〈/a〉