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  • 1
    Call number: PIK N 455-16-89710
    Type of Medium: Monograph available for loan
    Pages: XIII, 356 Seiten , Illustrationen
    ISBN: 9781107071421 (hardback)
    Language: English
    Note: Preface ; Acknowledgements ; List of contributors ; Part I. Diagnostics and Prediction of High-Impact Weather: 1. Global prediction of high-impact weather: diagnosis and performance Mark Rodwell and Alan Thorpe ; 2. Severe weather diagnosis from the perspective of generalized slantwise vorticity development Guoxiong Wu, Yongjun Zheng and Yimin Liu ; 3. Probabilistic extreme event attribution Pardeep Pall, Michael Wehner and Dáithí Stone ; 4. Observed and projected changes in temperature and precipitation extremes Xuebin Zhang and Francis Zwiers ; Part II. High-Impact Weather in Mid-Latitudes: 5. Rossby wave breaking: climatology, interaction with low-frequency climate variability, and links to extreme weather events Olivia Martius and Gwendal Rivière ; 6. The influence of jet stream regime on extreme weather events Nili Harnik, Chaim Garfinkel and Orli Lachmy ; 7. Forecasting high-impact weather using ensemble prediction systems Richard Swinbank, Petra Friederichs and Sabrina Wahl ; 8. Storm tracks, blocking and climate change: a review Tim Woollings ; 9. The North Atlantic and Arctic Oscillations: climate variability, extremes and stratosphere troposphere interaction Adam A. Scaife ; Part III. Tropical Cyclones: 10. Opportunities and challenges in dynamical and predictability studies of tropical cyclone events Russell L. Elsberry and Hsiao-Chung Tsai ; 11. Predictability of severe weather and tropical cyclones at the mesoscales Fuqing Zhang, Christopher Melhauser, Dandan Tao, Y. Qiang Sun, Erin B. Munsell, Yonghui Weng and Jason A. Sippel ; 12. Dynamics, predictability, and high-impact weather associated with the extratropical transition of tropical cyclones Patrick Harr and Heather M. Archambault ; 13. Secondary eyewall formation in tropical cyclones Chun-Chieh Wu, Yi-Hsuan Huang and Zhe-Min Tan ; 14. Seasonal forecasting of floods and tropical cyclones Tom Beer and Oscar Alves ; Part IV. Heat-Waves and Cold-Air Outbreaks: 15. European heat waves: the effect of soil moisture, vegetation and land use Fabio D'Andrea, Philippe Drobinski and Marc Stéfanon ; 16. Western North American extreme heat, associated large scale synoptic-dynamics, and performance by a climate model Richard Grotjahn ; 17. Decadel to interdecadel variations of Northern China heatwave frequency: impact of the Tibetan Plateau snow cover Zhiwei Wu and Jianping Li ; 18. Global warming targets and heatwave risk Robin Clark ; 19. Cold-air outbreaks over East Asia associated with blocking highs: mechanisms and their interaction with the polar stratosphere Hisashi Nakamura, Kazuaki Nishii, Lin Wang, Yvan J. Orsolini and Koutarou Takaya ; Part V. Ocean Connections: 20. Response of the Atlantic Ocean circulation to North Atlantic freshwater perturbations Henk A. Dijkstra ; 21. Key role of Atlantic Multidecadal Oscillation in twentieth-century drought and wet periods over the US Great Plains and the Sahel Sumant Nigam and Alfredo Ruiz-Barradas ; 22. Floods and droughts along the Guinea Coast in connection with the South Atlantic Dipole Hyacinth C. Nnamchi and Jianping Li ; 23. The effect of global dynamical factors on the interannual variability of land-based rainfall Peter G. Baines and Benjamin J. Henley ; 24. MJO and extreme weather and climate events Chidong Zhang ; Part VI. Asian Monsoons: 25. Extreme weather and seasonal events during the Indian summer monsoon and prospects of improvement in their prediction skill under India's monsoon mission D. R. Sikka ; 26. Interannual variability and predictability of summer climate over the Northwest Pacific and East Asia Shang-Ping Xie and Yu Kosaka ; 27. Impacts of Annular Modes on extreme climate events over the East Asian monsoon region Jianping Li ; Index.
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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  • 2
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The Duffy blood group system consists of three alleles, FYA, FYB, and FY. To study the molecular evolution of the three alleles, we established the polymorphism of a dinucleotide (GT) repeat sequence (designated FyGT/ C) in the 3′ flanking region of the Duffy gene, and studied the relationship between FyGT/C and Duffy polymorphism in Japanese, people of African origin, and chimpanzee. By single-strand conformation polymorphism and sequence analysis, five and two alleles were identified in Japanese and Africans, respectively. In 110 random Japanese, the FyGT/C genotypes observed were in agreement with Hardy-Weinberg law. From the sequence of the chimpanzee Duffy gene, including both flanking regions, FYB was identified as the ancestral gene of the human alleles. The FyGT/C sequences associated with the FY allele of Africans were distinct from those of Duffy positives, whereas the FYB and FYA alleles shared common FyGT/C sequences. Thus, it is suggested that the first split took place between the FYB and FY alleles, and the second between the FYB and FYA alleles.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Photoluminescence (PL) investigation was carried out on GaInP/GaAs multiple quantum wells structures grown on (001) and (311) B surfaces of GaAs by gas source molecular beam epitaxy. Superlattice structures of GaAs/GaInP grown on (001) GaAs substrate were also studied in comparison. Deep-level luminescence was seen to dominate the PL spectra from the quantum wells and superlattice structures that were grown on (001) GaAs substrate. In contrast, superior optical properties were exhibited in the same structures grown on (311) B GaAs surfaces. The results suggested that GaAs/GaInP quantum well structures on (311) B oriented substrates could efficiently suppress the deep-level emissions, result in narrower PL peaks indicating smooth interfaces. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    The visual computer 13 (1998), S. 391-400 
    ISSN: 1432-2315
    Keywords: Key words: Volume visualization ; Volume modeling ; Isosurface modeling ; Marching-cube algorithm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract.  An algorithm for computing isosurfaces from 3D volume data is presented that extends the standard marching-cube algorithm with two modifications. The first modification is that in the proposed algorithm, the status of a sample point on the isosurface depends on the number of edges (leading to this vertex) intersected by the isosurface. The second modification is that polygon vertices between two adjacent sample points are located at the middle point, which leads, in many cases, to co-planar triangles being merged to a polygon. The proposed algorithm reduces the number of polygons generated and thus increases efficiency, which is confirmed by experiments.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1572-8757
    Keywords: porous carbons ; activation ; oxidation ; surface oxygen groups ; LTPD
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Physics , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract A styrene/divinylbenzene copolymer has been used as precursor for making porous carbons with bimodal pore size distributions (i.e., with both microporosity and mesoporosity). Pretreatment of the as-received copolymer by mild oxidation in air, significantly increased the carbon yield after carbonization. Reactivity studies of the polymer-based chars to CO2 clearly show the influences of some important factors such as carbonization temperature, heating rate, soak time on char reactivities. Bimodal porous carbons were prepared by carbonization of the preoxidized styrene/divinylbenzene copolymer in N2, followed by activation in CO2 at different temperatures to different levels of burnoff. The pore structures of the porous carbons produced have been characterized by various techniques such as gas adsorption and mercury porosimetry. The surfaces of the porous carbons produced, and a commercial carbon adsorbent, have been modified with HNO3 and H2O2 treatment at various conditions. Characterization of the surface oxygen functionality, both quantitatively and qualitatively, has been achieved using techniques such as Linear Temperature Programed Desorption (LTPD) and selective neutralization of bases.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Molecular and cellular biochemistry 212 (2000), S. 211-217 
    ISSN: 1573-4919
    Keywords: angiotensin receptor ; medullary thick ascending limb ; sodium intake ; primary cell culture ; gene expression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Angiotensin II (Ang II) is an important regulator of the function of medullary thick ascending limb of loop of Henle (MTAL). Recent studies showed that changes in Ang II receptor expression occur and underlie changes in the function of proximal tubules during altered sodium intake. The present experiment was designed to determine (1) whether expression of the type 1 Ang II (AT1) receptor in the MTAL is regulated by altered sodium intake, and (2) the specific pathway(s) mediating sodium-induced AT1 expression in the MTAL. Wistar rats were fed a normal sodium (0.5%, NS), low sodium (0.07%, LS), or high sodium (4%, HS) diet for 2 weeks. Northern blot analysis and radioligand binding showed that in rats fed a normal sodium diet the rank of order for both AT1 mRNA expression and receptor density was outer medulla 〉 cortex 〉 inner medulla. Sodium restriction significantly increased both AT1 mRNA expression and receptor density in the outer medulla. In contrast, neither AT1 mRNA expression nor receptor density in the outer medulla was altered by sodium loading. Losartan treatment (3 mg/kg/per day by oral gavage for 2 weeks) prevented low sodium-induced upregulation of the AT1 receptor in the outer medulla, but it had no effect on AT1 expression in the outer medulla of rats fed a normal sodium diet. Highly purified suspensions of MTAL were isolated from rats fed a normal or low sodium diet. Low sodium intake significantly increased AT1 mRNA level by 184% and AT1 receptor density by 58% in MTALs. Primary cultures of MTAL cells were treated with PBS, Ang II (10-8 M), and Ang II + 17 octadecynoic (17 ODYA, 10 μM). Ang II caused about 2-fold increase in AT1 mRNA levels, and this increase was diminished by about 30% by the addition of 17 ODYA. We conclude that (1) sodium restriction but not sodium loading increases AT1 receptor expression in the MTAL, (2) low sodium-induced upregulation of the AT1 receptor in the MTAL is Ang II-dependent, and (3) Ang II-induced upregulation of the AT1 receptor in the MTAL is mediated, at least in part, by cytochrome P450 pathways.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 157 (1993), S. 263-270 
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Cells of the human promyelocytic HL-60 line, when treated with a variety of antitumor agents in the presence of the protein synthesis inhibitor cycloheximide (CHX), or with CHX alone, rapidly undergo apoptosis (“active cell death”). It is presumed, therefore, that such cells are “primed” to apoptosis in that no new protein synthesis is required for induction of their death. We have studied apoptosis of HL-60 cells triggered by the DNA topoisomerase I inhibitor camptothecin (CAM) in the absence and presence of CHX and apoptosis induced by CHX alone. Two different flcw cytometric methods were used, each allowing us to relate the apoptosis-associated DNA degradation to the cell cycle position. Apoptosis induced by CAM was limited to S phase cells, e.g., at a CAM concentration of 0.15 μM, nearly 90% of the S phase cells underwent apoptosis after 4 h. In contrast, apoptosis triggered by CHX was indiscriminate, affecting all phases of the cycle: ∼40% of the cells from each phase the cycle underwent apoptosis at 5 μM CHX concentration. When CAM and CHX were added together, the pattern of apoptosis resembled that of cycloheximide alone, namely, cells in all phases of the cycle in similar proportion were affected. Thus, CHX, while itself inducing apoptosis of a fraction of cells, protected the S phase cells against apoptosis triggered by CAM. Because CHX (5 μM) did not significantly affect the rate of cell progression through S phase, the observed protective effect was most likely directly related to inhibition of protein synthesis, rather than to its possible indirect effect on DNA replication. Furthermore, whereas apoptosis (DNA degradation) triggered by CAM was prevented by the serine protease inhibitor N-tosyl-L-lysylchloromethyl ketone (TLCK), this process was actually potentiated by this inhibitor when induced by CHX. The present data indicate differences in mechanism of apoptosis triggered by CAM (and perhaps other antitumor drugs) as compared with CHX. Apoptosis caused by CHX may be unique in that it may not involve new protein synthesis. These data are compatible with the assumption that the loss of a hypothetical, rapidly turning over suppressor of apoptosis may be the trigger of apoptosis of HL-60 cells treated with CHX, whereas de novo protein synthesis is required when apoptosis is triggered by other agents. © 1993 Wiley-Liss, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Publication Date: 2017-02-02
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 9
    Publication Date: 2019-05-06
    Print ISSN: 0003-6951
    Electronic ISSN: 1077-3118
    Topics: Physics
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  • 10
    Publication Date: 2017-06-05
    Description: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a class of antidiabetic drug used for the treatment of diabetes. These drugs are thought to lower blood glucose by blocking reabsorption of glucose by SGLT2 in the proximal convoluted tubules of the kidney. To investigate the effect of inhibiting SGLT2 on pancreatic hormones, we treated perfused pancreata from rats with chemically induced diabetes with dapagliflozin and measured the response of glucagon secretion by alpha cells in response to elevated glucose. In these type 1 diabetic rats, glucose stimulated glucagon secretion by alpha cells; this was prevented by dapagliflozin. Two models of type 2 diabetes, severely diabetic Zucker rats and db/db mice fed dapagliflozin, showed significant improvement of blood glucose levels and glucose disposal, with reduced evidence of glucagon signaling in the liver, as exemplified by reduced phosphorylation of hepatic cAMP-responsive element binding protein, reduced expression of phosphoenolpyruvate carboxykinase 2, increased hepatic glycogen, and reduced hepatic glucose production. Plasma glucagon levels did not change significantly. However, dapagliflozin treatment reduced the expression of the liver glucagon receptor. Dapagliflozin in rodents appears to lower blood glucose levels in part by suppressing hepatic glucagon signaling through down-regulation of the hepatic glucagon receptor.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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