ALBERT

Description: Journal of Medicinal Chemistry DOI: 10.1021/jm301475f

Description: Background The overall prognosis for most acute myeloid leukemia (AML) patients remains poor with only 50-55% of patients achieving durable remission. The majority of adult patients (pts) who do achieve remission, will ultimately need allogeneic stem cell transplant (allo-SCT) to achieve long term survival. Treatment of AML requires intensive therapy, transfusion support, antimicrobials, and repeated admissions to the hospital. Limited data is available comparing epidemiology and treatment according to the distance from patient residence to treatment center. Oklahoma University Health Sciences Center (OUHSC) is the major tertiary center for Oklahoma residents to receive treatment for AML. Few patients receive AML treatment from distant states or oversea areas. We describe a retrospective analysis of adult pts with AML treated at our institution evaluating impact on distance from center. Methods From January 2000 to June 2011,we identified a total of 269 patients with 217 meeting inclusion criteria for the study. We then performed an analysis of variance (ANOVA) on the relationship between distance to treatment center (in miles) and relapse rate or remission rates. Kaplan-Meier method was used to estimate survival rates. Age and cytogenetics were identified as the major confounders. A Cox Proportional Hazards model on overall survival (OS) was implemented using the independent variables age category ( ≤60 and 〉 60), cytogenetic risk status (groups were divided into favorable, intermediate and unfavorable risks), and distance to treatment center. Statistical analysis was performed using SAS 9.2 software (SAS Institute Inc.). Fisher’s exact test was used to compare patients in the different groups. Results Of the 217 pts (52.2% Males, 47.8% Females) included in the study, 81.5% were white, 9.0% African American, and 6.2% Native American. Median age at diagnosis was 51.0 years. Median distance to treatment center was 62 miles (range: 0-420). Distance of residence to treatment center was significantly related to complete remission rates, with patients living at longer distances having lower chances of achieving complete remission( p = 0.03). Distance from residence to treatment center however was not related to the risk of having relapsed disease (p = 0.22). A Cox proportional hazard model was performed including distance to travel, age and cytogenetic risks (unfavorable versus intermediate or favorable) and revealed that all three variables are associated with a trend towards shorter overall survival (p

Description: Under a nonreimbursable space act agreement between the NASA Lewis Research Center and the Allison Advanced Development Company, Allison tested a lift fan nozzle in Lewis' Powered Lift Rig. This test was in support of the Joint Strike Fighter program (formerly the Joint Advanced Strike Technology) sponsored by the Department of Defense, which will develop and field an affordable, multirole, next-generation, strike fighter aircraft for the Navy, Air Force, Marine Corps, and foreign allies. Allison, along with Pratt & Whitney Company, is part of the Lockheed Martin Corporation team that is scheduled to build a concept demonstrator aircraft by fiscal year 2001. The test was initiated in April and successfully completed in mid-July of 1997. Allison supplied a one-third-scale model of the lift fan nozzle, and Lewis provided the facility and the necessary support team. Various configurations, including pitching vectored angles ranging from 15deg forward to 60deg backward, were tested over a range of nozzle pressure ratios. Nozzle flow rates, thrust, and static pressures were measured for each of the configurations. Results from the test met the design requirements for the Joint Strike Fighter program and were in agreement with Allison's internal computational fluid dynamics (CFD) analyses. Data obtained from this test will also be used in the full-scale design of the lift fan system.

Description: The transonic performance of a dual-throat, single-expansion-ramp nozzle (SERN) was investigated with a PARC computational fluid dynamics (CFD) code, an external flow Navier-Stokes solver. The nozzle configuration was from a conceptual Mach 5 cruise aircraft powered by four air-breathing turboramjets. Initial test cases used the two-dimensional version of PARC in Euler mode to investigate the effect of geometric variation on transonic performance. Additional cases used the two-dimensional version in viscous mode and the three-dimensional version in both Euler and viscous modes. Results of the analysis indicate low nozzle performance and a highly three-dimensional nozzle flow at transonic conditions. In another comparative study using the PARC code, a single-throat SERN configuration for which experimental data were available at transonic conditions was used to validate the results of the over/under turboramjet nozzle.

Description: A discussion on the development of a Telescoping, Vaned, Exhaust Nozzle (TEVEN) is presented. This nozzle was challenged to meet the thrust vectoring requirements of an Advanced Short Takeoff and Vertical Landing (ASTOVL) aircraft. The nozzle underwent a development process from concepts to detail design using computational flow analyses and from subscale performance verification tests to full-scale hardware design. The LiftFan(Trademark) nozzle is capable of providing a pitch vector range of about 80 degrees from up to 20 degrees forward to 60 degrees aft. In addition, a set of post exit yaw doors provide +/- 10 degrees yaw while maintaining a relatively high performance at all operating conditions. Further, the nozzle is axially compact, to be stowable in very short length (LJD less than 0.3), while efficiently converging the upstream nozzle flow from an annular cross section to a "D" shape at the nozzle exit. The discussion includes a review of various nozzle concepts, viscous flow analyses, and results from 1/3 scale nozzle model tests conducted at NASA LeRC Powered Lift Facility (PLF) in 1994.