Publication Date:
1980-09-12
Description:
Application of arachidonic acid or prostaglandin G(2) to the brain surface of anesthetized cats induced cerebral arteriolar damage. Scavengers of free oxygen radicals inhibited this damage. Prostaglandin H(2), prostaglandin E(2), and 11,14,17-eicosatrienoic acid did not produce arteriolar damage. It appears that increased prostaglandin synthesis produces cerebral vascular damage by generating free oxygen radicals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kontos, H A -- Wei, E P -- Povlishock, J T -- Dietrich, W D -- Magiera, C J -- Ellis, E F -- New York, N.Y. -- Science. 1980 Sep 12;209(4462):1242-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403881" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Arachidonic Acids/*pharmacology
;
Arterioles/drug effects/pathology
;
Cats
;
Cerebral Arteries/*drug effects/pathology
;
Endothelium/drug effects/pathology
;
Hypertension/*pathology
;
Prostaglandin Endoperoxides/*pharmacology
;
Prostaglandins E/pharmacology
;
Prostaglandins G/*pharmacology
;
Prostaglandins H/pharmacology
;
Vasodilation/drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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