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  • Cannabinoid receptor  (1)
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    Electronic Resource
    Electronic Resource
    Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid (1996)
    Springer
    Cellular and molecular life sciences 52 (1996), S. 88-92 
    Details
    ISSN: 1420-9071
    Keywords: Cannabinoid receptor ; polyenoic fatty-acid isomerase ; marine enzyme ; anandamide ; red algae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A polyenoic fatty-acid isomerase (PFI) from a red marine alga was used to convert anandamide (5Z,8Z,11Z,14Z-eicosatetraenoyl-N-ethanolamide) to the 5Z,7E,9E,14Z-eicosatetraenoyl-N-ethanolamide isomer. This novel eicosanoid, termed conjugated triene anandamide (CTA), was assessed for its ability to bind to the cannabinoid receptor in rat brain membrane preparations. CTA is a high affinity cannabimimetic substance whose novel structure provides new insight into structure-activity relationships of cannabinoid receptor ligands. These experiments illustrate the utility of enzymes isolated from marine organisms in the development of pharmacological probes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01922423
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