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  • Springer  (67)
  • American Association for the Advancement of Science (AAAS)  (4)
  • Springer Science + Business Media
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 39 (1983), S. 362-364 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The 8-bromo derivative of cGMP was found to stimulate the ouabain-sensitive uptake of K+ and to reduce the net release of K+ induced by acetylcholine in rat submandibular gland slices incubated in vitro.
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 55 (1995), S. 142-148 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Conclusions The precise mechanism whereby DBCP residues contaminate water supplies is not known. It is, therefore, unlikely that DBCP can be kept out of ground water supplies if current application technology is followed. For this reason, and considering the widespread nature of contamination of well water, it is not likely that further agricultural use of DBCP should be authorized.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Archives of environmental contamination and toxicology 34 (1998), S. 152-157 
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract. Laboratory toxicity data contrasting responses of aquatic organisms to insecticides are important for focusing on sensitive species (steepest exposure-response slope) exposed to aqueous concentrations of these insecticides in field studies. These data also allow prediction of expected responses of aquatic species to a range of insecticide concentrations in situ. Aqueous 48-h toxicity tests were performed to contrast responses of Daphnia magna Straus, Hyalella azteca Saussure, Chironomus tentans Fabricius, and Pimephales promelas Rafinesque to acetylcholinesterase-inhibiting insecticides: chlorpyrifos, aldicarb, and chlordane. As expected, invertebrates tested (H. azteca, C. tentans, and D. magna) were ≥ 200 times more sensitive than the vertebrate P. promelas to chlorpyrifos exposures. H. azteca was approximately 3.5 times more sensitive to chlorpyrifos (453% mortality/μg/L) than D. magna (128% mortality/μg/L). For both aldicarb and chlordane, C. tentans was the most sensitive species tested (2.44 and 2.54% mortality/μg/L, respectively). Differences in chlordane potency for test species varied only by a factor of approximately 2–3 (0.88% mortality/μg/L for H. azteca to 2.54% mortality/μg/L for C. tentans). Although point estimates of population responses such as LC50s, NOECs, and LOECs are of some utility for predicting effects of pesticides in aquatic systems, exposure-response slopes are also useful for extrapolation of laboratory data to diverse field situations, especially where sediment sorption may regulate insecticide exposure or bioavailability.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Applied microbiology and biotechnology 44 (1995), S. 444-450 
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Genetic transformation of Wangiella dermatitidis was studied using three plasmid vectors (pAN7-1, pWU44, and pKK5) and both electroporation and polyethyleneglycol-mediated methods. pAN7-1 contains the E. coli hygromycin B (HmB) phosphotransferase (hph) gene. Expression of the hph gene confers resistance to antibiotic HmB. Selection for resistance, indicative of transformation, resulted in 10–203 HmB-resistant colonies/μg pAN7-1 on medium containing 100 μg HmB/ml. Strains of W. dermatitidis used in this study have innate sensitivity to HmB at a critical inhibitory concentration of 20–40 μg/ml. Vectors pWU44 and pKK5 contain a URA5 gene from Podospora anserina. A ura5 auxotroph of W. dermatitidis was transformed to prototrophy with pWU44 or pKK5 by complementation. Transformation frequencies for these two plasmids were between 17–50 transformants/μg vector DNA. Southern blotting analysis and polymerase chain reaction detection of DNA from putative transformants confirmed transformation.
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  • 6
    ISSN: 1432-0827
    Keywords: Key words: Bone density — Vitamin D receptor — Polymorphism — Growth — Genetic.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Family and twin studies have demonstrated a strong genetic component to the development of peak bone mass. Early fetal and infant environment has also been shown to influence bone mass through an effect on skeletal size and mineral content. We report a retrospective study that has examined whether early infant growth is regulated by genetic factors shown to be associated with bone mass. We have determined the vitamin D receptor (VDR) gene alleles for 66 women (mean age 65.5 years) on whom detailed birth records were available. There was a statistically significant trend (P= 0.04) for VDR genotype against weight at the age of 1 year, with the ``tt'' homozygote group having 7% higher weight. We conclude that early fetal or infant environment may interact with an individual's underlying genotype to program early skeletal growth, and that this may track through later life to influence adult characteristics. Further prospective studies are required, however, to fully clarify the precise environmental and genetic mechanisms underlying these findings.
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  • 7
    ISSN: 1432-0827
    Keywords: Key words: Bone metabolic markers — Predictor — Osteoporosis — Epidemiology — Bone mineral density.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. The purpose of this study was to ascertain whether biochemical markers of bone turnover predict bone loss. The survey was carried out in Taiji, Wakayama Prefecture, Japan. From a list of inhabitants aged 40–79 years, 400 participants (50 men and 50 women in each of four age groups) were selected randomly. Bone mineral density (BMD) was measured, and blood and urine samples of all participants were examined to obtain values for eight biochemical markers: alkaline phosphatase (ALP), bone Gla protein (BGP), type I procollagen (carboxyterminal peptide of type I procollagen; PICP), cross-linked carboxyterminal telopeptide region of type I collagen (ICTP), and urinary excretion of calcium (Ca), phosphate (P), pyridinoline (Pyr), and deoxypyridinoline (D-Pyr). Each marker was evaluated as a predictor of the rate of bone change in lumbar spine and femoral neck BMD over a 3-year period. The value of Pyr was significantly related to the change of lumbar spine BMD in men (P= 0.009), and that of BGP was found to be significant in women (P= 0.045). By contrast, none of the bone markers significantly correlated with bone loss at the femoral neck. The coefficient of determination at the lumbar spine was 5% and 7% at the femoral neck only. We conclude that biochemical markers of bone turnover cannot predict bone loss rates in middle-aged or elderly Japanese men and women over a 3-year period with sufficient accuracy for use in clinical decision making.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 60 (1997), S. 405 -409 
    ISSN: 1432-0827
    Keywords: Key words: Bone mineral density — Bone mineral content — Childhood growth — Dual X-ray absorptiometry — Muscle strength.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. In this population-based study, the relationship between childhood weight and height, and adolescent bone mass and muscle strength have been studied in 39 girls and 48 boys. Total body and femoral neck bone mass measurements (bone mineral content, BMC and bone mineral density, BMD) were made by dual X-ray absorptiometry. Quadriceps muscle strength was measured. Mean age at the time of measurement was 15.1 years for girls and boys. Results were individually linked to data on childhood (birth to 6 years of age) weight and height, taken from community health records. Childhood weight was found to be predictive of adolescent total body BMC (TBMC). However, this was not the case when correlating childhood weight and total body BMD (TBMD), suggesting that growth determines the size of the skeleton, whereas the density within that bone envelope is to a greater extent governed by other factors. Further, in a multiple regression model we found that the combined effect of childhood weight and height was significantly correlated with adolescent quadriceps muscle strength.
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  • 9
    ISSN: 1432-0894
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Results are presented from a new version of the Hadley Centre coupled model (HadCM3) that does not require flux adjustments to prevent large climate drifts in the simulation. The model has both an improved atmosphere and ocean component. In particular, the ocean has a 1.25° × 1.25° degree horizontal resolution and leads to a considerably improved simulation of ocean heat transports compared to earlier versions with a coarser resolution ocean component. The model does not have any spin up procedure prior to coupling and the simulation has been run for over 400 years starting from observed initial conditions. The sea surface temperature (SST) and sea ice simulation are shown to be stable and realistic. The trend in global mean SST is less than 0.009 °C per century. In part, the improved simulation is a consequence of a greater compatibility of the atmosphere and ocean model heat budgets. The atmospheric model surface heat and momentum budget are evaluated by comparing with climatological ship-based estimates. Similarly the ocean model simulation of poleward heat transports is compared with direct ship-based observations for a number of sections across the globe. Despite the limitations of the observed datasets, it is shown that the coupled model is able to reproduce many aspects of the observed heat budget.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Environmental management 26 (2000), S. 317-328 
    ISSN: 1432-1009
    Keywords: KEY WORDS: Streambank erosion; Stream bank protection; Fish; Habitat; Stream restoration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
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