Publication Date:
1981-10-09
Description:
Intraventricular administration of supraphysiological amounts of renin, nerve growth factor preparation, or angiotensin II greatly increased the consumption of water and hypertonic sodium bicarbonate solution by sheep. These effects were antagonized by intraventricular administration of drugs that prevent the formation of angiotensin II or block its receptors. The fact that these angiotensin-blocking drugs did not change the sodium intake of sodium-deficient sheep challenges the idea that central angiotensin action is involved in sodium appetite due to a deficiency.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coghlan, J P -- Considine, P J -- Denton, D A -- Fei, D T -- Leksell, L G -- McKinley, M J -- Muller, A F -- Tarjan, E -- Weisinger, R S -- Bradshaw, R A -- New York, N.Y. -- Science. 1981 Oct 9;214(4517):195-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6169149" target="_blank"〉PubMed〈/a〉
Keywords:
Angiotensin II/*pharmacology
;
Animals
;
Appetite/*drug effects
;
Drinking Behavior/drug effects
;
Injections, Intraventricular
;
Nerve Growth Factors/pharmacology
;
Renin/pharmacology
;
Saralasin/pharmacology
;
Sheep
;
Sodium/deficiency/*metabolism
;
Teprotide/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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