Two new triazoles, chrysotriazoles A and B ( 1 and 2 , resp.), along with two known quinazolinones, 3 and 4 , two known 2-(4-hydroxyphenyl)acetamides, 5 and 6 , and two known N -(4-hydroxystyryl)formamides, 7 and 8 , were isolated and identified from the culture extract of Penicillium chrysogenum EN-118, an endophytic fungus obtained from the marine brown alga Sargassum pallidium. The structures of the isolated compounds were elucidated by NMR-spectroscopic analysis, and that of compound 1 was confirmed by X-ray crystallographic analysis of its p -bromobenzoate derivative. Compounds 4, 5 , and 7 showed moderate cytotoxicities against Du145, A-549, and HeLa cell lines.
Chemistry and Pharmacology