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  • 1
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 88 (1988), S. 5323-5330 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The x-ray emission processes associated with K, L1, and L2,3 chlorine core shell ionization in the CH3Cl molecule have been studied using ab initio molecular orbital methods. The energy and absolute transition rates of XES processes have been calculated. Comparison with atomic calculations is used to identify weak molecular effects. For the Kβ spectrum relaxation terms must be included to obtain good agreement between the calculated and experimental spectra. It is concluded that three transitions are major contributors to the Kβ spectrum. However, a one-center model is adequate to account for the Kα spectrum. Uncertainty regarding the extent of satellite contribution to the experimental L2,3 spectrum and the breakdown of the single particle model has made direct comparison between theory and experiment difficult. New measurements and a more refined theoretical approach beyond the relaxed Hartree–Fock model are desirable. The L2,3 and L1 or Kβ emission spectra provide complementary information for probing the valence electronic structure of the CH3Cl molecule.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 28 (1995), S. 5734-5744 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 11 (1949), S. 493-526 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 206 (1965), S. 1367-1368 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Cholera, like the vegetable cathartics, evokes a profuse diarrhoea. A previous investigation4 from this laboratory suggested that the diarrhoea of cholera might be due to inhibition of active transport of Na+ ions by intestinal mucosa cells. Subsequently it was reported that such an inhibitor is ...
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 220 (1968), S. 814-815 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The fluid accumulation factor (FAF) in Vibrio cholerae culture filtrates rapidly loses its effectiveness even if the filtrates are stored at 4 C. Van Heyningen has suggested (personal communication) that stabilization might be achieved by the addition of glycerine to the filtrate in a ratio of 2 : ...
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  • 6
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Inheritance of a mutation at the Rb-1 locus, which has been mapped to band q14 of human chromosome 13, results in predisposition to retinoblastoma. Cloned DNA segments homologous to arbitrary loci of human chromosome 13 and which reveal polymorphic restriction endonuclease recognition sequences, ...
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 304 (1983), S. 451-453 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Karyotypic analysis of more than 30 retinoblastoma tumours both in our laboratory4 and by Kuznetsova et al.5 has failed to show a high frequency of abnormalities of chromosome 13; in only one case was there a somatic deletion involving the 13ql4 locus. However, Balaban et al.6 found that five of ...
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 347 (1990), S. 479-482 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In a series of experiments designed to investigate the function of non-lymphoid haematopoietic cells in scid mice, we exposedscid mice and coisogenic normal C.B-17 mice to sublethal doses of y~radiation to study endogenous spleen colonies derived from stem cells in spleen. Sublethal irradiation ...
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 251 (1974), S. 444-446 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] B lymphocytes differentiate from pluripotent stem cells in the bone marrow3-4. These cells are probably identical or closely related to haemopoietic stem cells. Specificity-restricted precursors of B cells (PB cells) are also found in bone marrow and seem to represent a stage intermediate between ...
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 70 (1985), S. 291-301 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Full cytogenetic analysis of 27 different retinoblastoma tumors is presented. Gross aneuploidy of chromosome arms 6p and 1q were very common, being observed in 15/27 and 21/27 tumors, respectively. However, we found that chromosome 13 was rarely missing: only 3/27 had a detectable monosomy affecting 13q14. Monosomy of chromosome 13 by small deletion or rearrangement was also not observed in any of 12 retinoblastoma tumor lines analyzed detail at the 300–400 chromosome band level. A novel observation in retinoblastoma was the discovery of non-random translocations at three specific breakpoints, 14q32 (4/12), 17p12 (5/12), and 10q25 (3/12). Genomic rearrangements similar to those described involving C-myc in Burkitt lymphoma 14q+ cells could not be demonstrated in the four 14q+ retinoblastoma lines using molecular techniques, and a probe mapping to the site implicated to have an activating role in lymphoma. These data suggest that there is a target for rearrangement at 14q32 but it is not the same sequence used in some Burkitt lymphomas. Two other breakpoints (2p24 and 8q24) coincided with the mapped position of cellular oncogenes, but also failed to show a molecular rearrangement with the oncogene probes. The breakpoints, 10q25 and 17p12, are constitutional fragile sites which may predispose these regions to act as acceptors of translocations in malignant cells. One line had double minute chromosomes, and was the only one of 16 (6%) tested with the N-myc probe which had an amplification. Different tumors from single patients with multifocal heritable retinoblastoma showed independent karyotype evolution. Unilateral non-heritable tumors exhibited a high level of karyotype stability throughout both in vivo and in vitro growth. The various common patterns of aneuploidy and translocations probably confer an early selective advantage to malignant cells, rather than induce malignant transformation.
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