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  • 1
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    The Genome of the Self-Fertilizing Mangrove Rivulus Fish, Kryptolebias marmoratus: A Model for Studying Phenotypic Plasticity and Adaptations to Extreme Environments (2016)
    Oxford University Press
    Details
    Publication Date: 2016-08-17
    Description: The mangrove rivulus ( Kryptolebias marmoratus ) is one of two preferentially self-fertilizing hermaphroditic vertebrates. This mode of reproduction makes mangrove rivulus an important model for evolutionary and biomedical studies because long periods of self-fertilization result in naturally homozygous genotypes that can produce isogenic lineages without significant limitations associated with inbreeding depression. Over 400 isogenic lineages currently held in laboratories across the globe show considerable among-lineage variation in physiology, behavior, and life history traits that is maintained under common garden conditions. Temperature mediates the development of primary males and also sex change between hermaphrodites and secondary males, which makes the system ideal for the study of sex determination and sexual plasticity. Mangrove rivulus also exhibit remarkable adaptations to living in extreme environments, and the system has great promise to shed light on the evolution of terrestrial locomotion, aerial respiration, and broad tolerances to hypoxia, salinity, temperature, and environmental pollutants. Genome assembly of the mangrove rivulus allows the study of genes and gene families associated with the traits described above. Here we present a de novo assembled reference genome for the mangrove rivulus, with an approximately 900 Mb genome, including 27,328 annotated, predicted, protein-coding genes. Moreover, we are able to place more than 50% of the assembled genome onto a recently published linkage map. The genome provides an important addition to the linkage map and transcriptomic tools recently developed for this species that together provide critical resources for epigenetic, transcriptomic, and proteomic analyses. Moreover, the genome will serve as the foundation for addressing key questions in behavior, physiology, toxicology, and evolutionary biology.
    Electronic ISSN: 1759-6653
    Topics: Biology
    Published by Oxford University Press
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  • 2
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    Restricting mitochondrial GRK2 post-ischemia confers cardioprotection by reducing myocyte death and maintaining glucose oxidation (2018)
    The American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2018
    Description: 〈p〉Increased abundance of GRK2 [G protein–coupled receptor (GPCR) kinase 2] is associated with poor cardiac function in heart failure patients. In animal models, GRK2 contributes to the pathogenesis of heart failure after ischemia-reperfusion (IR) injury. In addition to its role in down-regulating activated GPCRs, GRK2 also localizes to mitochondria both basally and post-IR injury, where it regulates cellular metabolism. We previously showed that phosphorylation of GRK2 at Ser〈sup〉670〈/sup〉 is essential for the translocation of GRK2 to the mitochondria of cardiomyocytes post-IR injury in vitro and that this localization promotes cell death. Here, we showed that mice with a S670A knock-in mutation in endogenous GRK2 showed reduced cardiomyocyte death and better cardiac function post-IR injury. Cultured GRK2-S670A knock-in cardiomyocytes subjected to IR in vitro showed enhanced glucose-mediated mitochondrial respiratory function that was partially due to maintenance of pyruvate dehydrogenase activity and improved glucose oxidation. Thus, we propose that mitochondrial GRK2 plays a detrimental role in cardiac glucose oxidation post-injury.〈/p〉
    Print ISSN: 1945-0877
    Electronic ISSN: 1937-9145
    Topics: Biology , Medicine
    Published by The American Association for the Advancement of Science (AAAS)
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  • 3
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    Intracellular recordings from cochlear inner hair cells: effects of stimulation of the crossed olivocochlear efferents (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-10-07
    Description: Intracellular recordings were obtained from inner hair cells located in the lower basal turn of the guinea pig cochlea. At low sound pressure levels the inner hair cells were highly frequency selective, producing receptor potentials only in response to sound frequencies between about 16 and 24 kilohertz. Electrical stimulation of efferent nerves in the crossed olivocochlear bundle markedly reduced these receptor potentials while causing little change in the resting membrane potential. At high sound levels, where cells responded to an increasingly wider range of sound frequencies, stimulation was less effective in reducing receptor potentials. Since the crossed olivocochlear bundle primarily innervates outer hair cells, these results support an outer hair cell contribution to the most sensitive response region of inner hair cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, M C -- Nuttall, A L -- Masta, R I -- NS-05785/NS/NINDS NIH HHS/ -- NS-07106/NS/NINDS NIH HHS/ -- NS-15107/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Oct 7;222(4619):69-72.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623058" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways/physiology ; Animals ; Cochlea/*physiology ; Electric Stimulation ; Guinea Pigs ; Hair Cells, Auditory/*physiology ; Hair Cells, Auditory, Inner/*physiology ; Hearing/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Postsynaptic transmission block can cause terminal sprouting of a motor nerve (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-08
    Description: Sprouting of mouse soleus motor nerve terminals can be evoked by daily intramuscular injections of purified alpha-bungarotoxin. This finding supports the hypothesis that an important stimulus to terminal sprouting in partial denervation and presynaptic nerve blockade is a product of inactive muscle fibers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holland, R L -- Brown, M C -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):649-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6243417" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Botulinum Toxins/pharmacology ; Bungarotoxins/*pharmacology ; Female ; Mice ; Motor Endplate/drug effects ; Motor Neurons/*growth & development ; Muscles/innervation ; Neuromuscular Junction/*physiology ; Receptors, Cholinergic/drug effects ; Synaptic Transmission/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Snapshot of the matuyama-brunhes reversal process recorded in 40Ar/39 Ar-dated lavas from Guadeloupe, West Indies (2013)
    Wiley
    Details
    Publication Date: 2013-09-01
    Description: We obtain new 40 Ar/ 39 Ar ages for three lavas that record part of the Matuyama-Brunhes geomagnetic field reversal process on Guadeloupe. These lavas record a reversed-transitional-reversed magnetostratigraphy and yield a weighted mean isochron age of 785.2 ± 5.2 ka (2σ analytical uncertainty) relative to an age for the Fish Canyon sanidine standard of 28.201 Ma. This age is of greater accuracy than ages obtained previously by K-Ar dating. These lavas may record directional fluctuations occurring between the Matuyama-Brunhes precursor and the final directional reversal. Such variations have been observed in some globally distributed coupled paleomagnetic and oxygen isotope marine sedimentary records of the Matuyama-Brunhes reversal. Previous paleointensity estimates from these lavas indicate reduced, but fluctuating field strength during this time.
    Electronic ISSN: 1525-2027
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 6
    Electronic Resource
    Electronic Resource
    Quantitative studies on the slowly adapting stretch receptor of the crayfish (1966)
    Springer
    Biological cybernetics 3 (1966), S. 175-185 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Summary In isolated receptors the impulse frequency following “step” stretches had a highly significant correlation with both muscle length and tension; any deviations from linearity were in opposite directions, impulse frequency rising more quickly than linearly with length and more slowly than linearly with tension. The impulse frequency decayed according to a power function of time from application of a step increase in length. A transfer function was derived and used to predict responses to sinusoidal and constant velocity stretches. The experimental data generally agreed with predictions. The deviations that were found could be accounted for by considering quantitatively any non-linearity between frequency and length, the adaptation of the impulse frequency to constant currents, the all-or-none nature of the action potential, and the viscous forces present during dynamic stretch. The approximately linear relationship between impulse frequency and muscle length and muscle tension is discussed. Muscle tension appears to be the more direct causal agent of impulse generation. Possible physical bases for the transfer function are also considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00290253
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  • 7
    Electronic Resource
    Electronic Resource
    Motor Nerve Sprouting (1981)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Neuroscience 4 (1981), S. 17-42 
    Details
    ISSN: 0147-006X
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ne.04.030181.000313
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  • 8
    Electronic Resource
    Electronic Resource
    Carbendazim resistance in the eyespot pathogen Pseudocercosporella herpotrichoides (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Plant pathology 33 (1984), S. 0 
    Details
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Mycelial isolates (115) of Pseudocercosporella herpotrichoides were obtained from five field sites in England. Carbendazim-resistant isolates were detected by their mycelial growth on agar containing 1 μg/ml carbendazim. Resistant isolates were found at two of the five sites examined and one of these had never been treated with benzimidazole fungicides. Amongst the carbendazim- resistant isolates there was a predominance of isolates with pale mycelium, an irregular colony margin and a relatively slow growth rate; however, this association was not absolute. Large differences in the effects of carbendazim on mycelial growth of sensitive and resistant isolates were demonstrated; growth of sensitive isolates was completely inhibited at 0.5 μg /ml carbendazim whilst five of the six resistant isolates examined grew on agar containing 1000 μg/ml fungicide. The carbendazim-resistant isolates were cross-resistant to benomyl, thiophanate-methyl and to a Icsser degree thiabendazole, but not to prochloraz. Conidia of carbendazim-resistant isolates were as resistant. Carbendazim-resistant isolates were just as pathogenic to wheat as sensitive isolates. The implications of these results and other reports of benzimidazole resistance in P. herpotrichoides are discussed in relation to disease control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3059.1984.tb00593.x
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  • 9
    Electronic Resource
    Electronic Resource
    Postnatal development of the adult pattern of motor axon distribution in rat muscle (1983)
    [s.l.] : Nature Publishing Group
    Nature 304 (1983), S. 741-742 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Experiments were carried out on the sheet-like gluteus muscle of neonatal rats aged 0-1 days and 13-17 days. The muscle (Fig. 1) varies between 12 and 25 fibres thick and is innervated by about 20 motor axons. It arises medially from the iliac crest and inserts into the femur and fascia of the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/304741a0
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  • 10
    Electronic Resource
    Electronic Resource
    Antidromic inhibition of presumed fusimotor neurones by repetitive stimulation of the ventral root in the decerebrate cat (1968)
    Springer
    Cellular and molecular life sciences 24 (1968), S. 1210-1211 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé On a enregistré des décharges de 17 fibres fusimotrices dont on suppose l'existence dans les filaments de racines ventrales des chats décérébrés. 8 fibres ont été inhibées par stimulation répétée de la portion centrale isolée du reste de la racine ventrale. Ces résultats montrent qu'il existe une inhibition antidromique dans les neurones fusimoteurs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02146625
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