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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Molecular biology. ; Metabolism. ; Genetics. ; Cytology. ; Biomedical Research. ; Molecular Biology. ; Metabolism. ; Genetics and Genomics. ; Cell Biology.
    Description / Table of Contents: Introduction (Moray J Campbell & Charlotte L Bevan) -- Overview (Jason Carroll) -- Part I: Reproduction and Development -- Chapter 1. Nuclear receptors in pregnancy and outcomes: clinical perspective (Luiza Borges Manna & Catherine Williamson) -- Chapter 2. Female Reproductive Systems: hormone dependence and receptor expression (Philippa TK Saunders) -- Chapter 3. Nuclear receptors in ovarian function (Darryl Russell & Doan Thao Dinh) -- Part II: Metabolism -- Chapter 4. Nuclear receptors in energy metabolism (Alina Walth, Stephan Herzig & Maria Rohm) -- Chapter 5. Nuclear Receptors and lipid sensing (James L Thorne and Giorgia Cioccoloni) -- Part III: Central Systems -- Chapter 6. Corticosteroid receptors in Cardiac health and disease (Jessica Ivy, Gillian Gray, Megan Holmes, Martin Denvir, Karen Chapman) -- Chapter 7. Physiological convergence and antagonism between GR and PPARγ in inflammation and metabolism (Marija Dacic, Gayathri Shibu and Inez Rogatsky) -- Chapter 8. Circadian Rhythm and Nuclear Receptors (David W Ray) -- Chapter 9. Vitamin D and gut health (James C Fleet) -- Part IV: Cancer -- Chapter 10. Estrogen Receptor alpha and ESR1 Mutations in Breast Cancer (Jaymin Patel & Rinath Jeselsohn) -- Chapter 11. AR structural variants and prostate cancer (Laura Cato) -- Chapter 12. ERβ and inflammation (Linnea Hases, Amena Archer & Cecilia Williams) -- Chapter 13. Genomic insights into non-steroidal nuclear receptors in prostate and breast cancer (Sajad A Wani & Moray Campbell) -- Part V: New developments in transcriptional control by nuclear receptors -- Chapter 14. Protein condensation in the nuclear receptor family; implications for transcriptional output (Monique Appelman, Elle Hollaar, Jurian Schuijers & Saskia WC van Mil) -- Chapter 15. Prostate cancer epigenetic plasticity and enhancer heterogeneity: molecular causes, consequences and clinical implications (Jeroen Kneppers, Andries M Bergman & Wilbert Zwart) -- Chapter 16. Epigenetic coregulation of androgen receptor signaling (Rayzel Fernandes, Damien A. Leach & Charlotte Bevan) -- Part VI: Clinical Translation -- Chapter 17. Cllnical Translation: Targeting the Estrogen Receptor (Jennifer O. Lauchle & Ciara Metcalfe) -- Chapter 18. Drugging the undruggable: targeting the N-terminal domain of nuclear hormone receptors (Marianne Sadar) -- Chapter 19. Genetic Variation and Mendelian Randomization approaches (Mojgan Yazdanpanah, Nahid Yazdanpanah & Despoina Manousaki) -- Index.
    Abstract: This book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the reader our current understanding of NR signaling in the development and functioning of the reproductive system; the roles in the regulation of energy metabolism; and how NR signaling is more widely integrated into systemic functions from calcium flux to circadian rhythm. The subsequent three sections dissect how aberrant NR functions drive Cancer; how new insights into Genomic Interaction are helping to reveal how NR disruption drives disease; and finally, how Translational Efforts are exploiting this understanding from developing novel NR ligands to establishing how underlying genetic variation impacts NR function. Within these sections the chapters also illustrate emerging understanding of how the epigenome and non-coding genome combine to regulate NR function and impact dysfunction. Increasingly these insights cross-fertilize over cell and disease boundaries and it is unsurprising that NR are being explored in novel and new arenas such as the context of neurological disorders and depression. Thus, there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases. This unique book brings together many of the leading figures in NR research from across the globe, to discuss emerging roles and their implications for human health and disease. It summarizes the state of the art and shows signposts for future research to further shape this influential field.
    Type of Medium: Online Resource
    Pages: XII, 346 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031118364
    Series Statement: Advances in Experimental Medicine and Biology, 1390
    DDC: 610.72
    Language: English
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  • 2
    Keywords: Soil science. ; Physical geography. ; Geomorphology. ; Ecology . ; Soil Science. ; Physical Geography. ; Geomorphology. ; Ecology.
    Description / Table of Contents: Introduction -- History of Soil Studies -- Soil-Forming Factor -- Elevation Gradients in the Oregon Mountain Ranges -- General Soil Regions of Oregon -- Diagnostic Horizons and Taxonomic Structure of Oregon Soils -- Taxonomic Soil Regions -- Mollisols -- Inceptisols -- Aridisols -- Andisols -- Ultisols -- Alfisols -- Entisols, Vertisols, Spodosols, and Histosols -- Soil-Forming Processes -- Benchmark, Endemic, Rare, and Endangered Soils -- Land Use in Oregon -- Yields, Soil Conservation, and Production System -- Summary.
    Abstract: This book is the only comprehensive summary of natural resources of Oregon and adds to World Soil Book Series state-level collection. Due to broad latitudinal and elevation differences, Oregon has an exceptionally diverse climate, which exerts a major influence on soil formation. The mean annual temperature in Oregon ranges from 0°C in the Wallowa and Blue Mountains of northeastern Oregon to 13°C in south-central Oregon. The mean annual precipitation ranges from 175 mm in southeastern Oregon to over 5,000 mm at higher elevations in the Coast Range. The dominant vegetation type in Oregon is temperate shrublands, followed by forests dominated by lodgepole pine, Douglas-fir, and mixed conifers, grasslands, subalpine forests, maritime Sitka spruce-western hemlock forests, and ponderosa pine-dominated forests. Oregon is divided into 17 Major Land Resource Areas, the largest of which include the Malheur High Plateau, the Cascade Mountains, the Blue Mountain Foothills, and Blue Mountains. The single most important geologic event in Oregon was the deposition of Mazama ash 7,700 years by the explosion of Mt. Mazama. Oregon has soil series representative of 10 orders, 40 suborders, 114 great groups, 389 subgroups, over 1,000 families, and over 1,700 soil series. Mollisols are the dominant order in Oregon, followed by Aridisols, Inceptisols, Andisols, Ultisols, and Alfisols. Soils in Oregon are used primarily for forest products, livestock grazing, agricultural crops, and wildlife management. Key land use issues in Oregon are climate change; wetland loss; flooding; landslides; volcanoes, earthquakes, and tsunamis; coastal erosion; and wildfires.
    Type of Medium: Online Resource
    Pages: XIX, 545 p. 229 illus., 197 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030900915
    Series Statement: World Soils Book Series,
    DDC: 631.4
    Language: English
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  • 3
    Online Resource
    Online Resource
    Cham :Springer Nature Switzerland :
    Keywords: Biogeography. ; Physical geography. ; Biogeosciences. ; Physical Geography. ; Earth System Sciences.
    Description / Table of Contents: Chapter 1: Biogeochemistry and its Complexity -- Chapter 2: The Background of Geochemistry -- Chapter 3: Earth Systems Science and Systems Ecology -- Chapter 4: Biogeochemistry, Biogeography and Geomatics -- Chapter 5: Biogeochemistry and Oceanography -- Chapter 6: Biogeochemistry and Conservation Biology -- Chapter 7: The Future Developments of Biogeochemistry.
    Abstract: Biogeochemistry may be defined as the science that combines biological and chemical perspectives for the examination of the Earth’s surface, including the relations between the biosphere, lithosphere, atmosphere, and hydrosphere. Biogeochemistry is a comparatively recently developed science, that incorporates scientific knowledge and findings, research methodologies, and models linking the biological, chemical, and earth sciences. Therefore, while it is a definitive science with a strong theoretical core, it is also dynamically and broadly interlinked with other sciences. This book examines the complex science of biogeochemistry from a novel perspective, examining its comparatively recent development, while also emphasizing its interlinked relationship with the earth sciences (including the complementary science of geochemistry), the geographical sciences (biogeography, oceanography, geomatics, earth systems science), the biological sciences (ecology, wildlife studies, biological aspects of environmental sciences) and the chemical sciences (including environmental chemistry and pollution). The book covers cutting-edge topics on the science of biogeochemistry, examining its development, structure, interdisciplinary, multidisciplinary, and transdisciplinary relations, and the future of the current complex knowledge systems, especially in the context of technological, developments, and the computer and data fields. .
    Type of Medium: Online Resource
    Pages: XIII, 430 p. 10 illus., 9 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031470172
    DDC: 578.09
    Language: English
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  • 4
    Monograph available for loan
    Monograph available for loan
    Basel [u.a.] : Birkhäuser
    Call number: M 97.0289
    Type of Medium: Monograph available for loan
    Pages: S. 315-549
    Edition: Reprint
    ISBN: 3764323388
    Classification:
    Geomagnetism, Geoelectromagnetism
    Language: English
    Location: Upper compact magazine
    Branch Library: GFZ Library
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  • 5
    Monograph available for loan
    Monograph available for loan
    Cambridge : Cambridge Univ. Press
    Call number: M 98.0080 ; 5/M 02.0050
    Type of Medium: Monograph available for loan
    Pages: 290 S.
    Edition: 1st publ.
    ISBN: 0521571936
    Classification:
    Geomagnetism, Geoelectromagnetism
    Language: English
    Location: Upper compact magazine
    Location: Reading room
    Branch Library: GFZ Library
    Branch Library: GFZ Library
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  • 6
    Monograph available for loan
    Monograph available for loan
    Amsterdam [u.a.] : Elsevier
    Associated volumes
    Call number: PIK W 111-92-0650
    In: Developments in soil science
    Type of Medium: Monograph available for loan
    Pages: XVI, 150 S. , graph. Darst.
    Edition: 3. impression
    ISBN: 0444425578
    Series Statement: Developments in soil science 14
    Branch Library: PIK Library
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  • 7
    Call number: ZSP-202-315
    In: Research report
    Description / Table of Contents: CONTENTS: Preface. - Introduction. - Part 1:Mesoscale strain measurements on the Beaufort Sea pack ice. - Abstract. - Introduction. - Previous work. - Site location. - Results. - Correlation of synoptic aerial photography with measured strains. - Correlation of estimated wind stress and strain. - Conclusions. - Literature cited. - Part II: Structure of a multiyear pressure ridge. - Abstract. - Introduction. - Profiles. - Internal properties. - Largest ridge sail. - Conclusions. - Literature cited. - Part III: Top and bottom roughness of a multiyear ice floe. - Abstract. - Introduction. - Results. - Literature cited. - Part IV:Airphoto analysis of ice deformation in the Beaufort Sea Abstract. - Introduction. - Study area. - Method of analysis. - Ice deformations. - Net deformational changes. - Pressure ridge distribution. - Summary and conclusions. - Literature cited. - Part V: Data on morphological and physical characteristics of sea ice in the Beaufort Sea.
    Description / Table of Contents: Mesoscale strain measurements on the Beaufort Sea pack ice; Structure of a multiyear pressure ridge; Top and bottom roughness of a multiyear ice floe; Airphoto analysis of ice deformation in the Beaufort Sea; Data on morphological and physical characteristics of sea ice in the Beaufort Sea.
    Type of Medium: Series available for loan
    Pages: iii, 66 Seiten , Illustrationen
    Series Statement: Research report / Cold Regions Research and Engineering Laboratory, CRREL, US Army Material Command 315
    Language: English
    Branch Library: AWI Library
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  • 8
    Series available for loan
    Series available for loan
    Washington, DC : United States Gov. Print. Off.
    Associated volumes
    Call number: SR 90.0001(1027-D)
    In: U.S. Geological Survey bulletin
    Type of Medium: Series available for loan
    Pages: IV S., S. 143-250 + 8 pl.
    Series Statement: U.S. Geological Survey bulletin 1027-D
    Language: English
    Location: Lower compact magazine
    Branch Library: GFZ Library
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  • 9
    Series available for loan
    Series available for loan
    Washington, DC : United States Gov. Print. Off.
    Associated volumes
    Call number: SR 90.0002(851)
    In: Professional paper
    Type of Medium: Series available for loan
    Pages: IV, 51 S.
    Series Statement: U.S. Geological Survey professional paper 851
    Language: English
    Location: Lower compact magazine
    Branch Library: GFZ Library
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  • 10
    Series available for loan
    Series available for loan
    Washington, DC : United States Gov. Print. Off.
    Associated volumes
    Call number: SR 90.0001(1142-F)
    In: U.S. Geological Survey bulletin
    Type of Medium: Series available for loan
    Pages: IV, F-53 S. + 2 pl.
    Series Statement: U.S. Geological Survey bulletin 1142-F
    Language: English
    Location: Lower compact magazine
    Branch Library: GFZ Library
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