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  • 1
    ISSN: 1434-193X
    Keywords: Cyclodextrins ; Inclusion compounds ; Carcinine ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---A new modified β-cyclodextrin (β-CD) derivative 1 that was functionalized in position 6 with Boc-Carcinine was synthesised and its crystal structure was determined. The structure reveals a “sleeping swan”-like shape, the covalently bonded Boc-Carcinine moiety forming a folded structure with the Boc group inserted within the hydrophobic cavity of the β-cyclodextrin. The conformation of the Carcinine moiety is determined by the inclusion of the Boc group and is further stabilised by three intramolecular hydrogen bonds, two between the amide N1-H group, the carbonyl C′1=O1 group and a primary hydroxylic group of the glucose unit 5, one between the carbonyl C′0=O0 group and the primary hydroxylic group of the glucose unit 2. The β-CD macrocycle differs only slightly from unmodified β-CDs, maintaining an approximate sevenfold symmetry. The solution structure of the new β-CD derivative was investigated by NMR spectroscopy and circular dichroism (c.d.) spectroscopy. In addition to a complete (1H and 13C) assignment of the pendant Boc-Carcinine group, the NMR study allowed the assignment of all the proton resonances associated with the β-CD macrocycle. Furthermore, NMR and c.d. results indicated that the self-inclusion of the Boc group within the β-CD cavity is retained in aqueous solution. In order to estimate the strength of this self-inclusion complex a series of competition experiments with the external guest 1-adamantanol was carried out using c.d. spectroscopy.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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