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  • 1
    Online Resource
    Online Resource
    Molecularly Imprinted Polymers as Advanced Drug Delivery Systems : Synthesis, Character and Application (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Drug delivery systems. ; Biotechnology. ; Pharmacology. ; Drug Delivery. ; Biotechnology.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Synthetic Strategies for the Generation of Molecularly Imprinted Polymers -- Chapter 3. Special Control by Molecular Imprinting Materials-zero-order Sustained Release, Enantioselective MIPs and Self-regulated Drug Delivery Microdevices -- Chapter 4. Water Compatible Molecularly Imprinted Polymers -- Chapter 5. Stimuli Responsive Imprinted DDS -- Chapter 6. MIP as Drug Delivery Systems for Dermal Delivery -- Chapter 7. MIP as Drug Delivery Systems of Anticancer Agents -- Chapter 8. MIP as Dug Delivery Systems of Ophthalmic Drugs -- Chapter 9. MIP as Drug Delivery Systems for Special Application -- Chapter 10. Outlook.
    Abstract: This book summarizes the recent advancements for drug delivery systems (DDS) in terms of fundamental principles, rapidly emerging techniques and developing frontiers of molecular imprinting. Especially with the combination of enantioselective molecularly imprinted polymers and water compatible molecularly imprinted polymers, stimuli responsive imprinted DDS have been innovated and applied to dermal delivery, ophthalmic drugs and cancer treatment. This philosophy comprehensively revolutionizes the treatment strategy of human healthcare and provides the possibility to re-trigger in vivo an exhaust system after the complete release of the starting drug cargo, thus enabling precision medicine. To this end, the following unique features will be discussed and concluded: 1) State-of-the-art definition of MIP as drug delivery systems. 2) Advanced techniques and clinical applications of MIP as drug delivery systems in the past decade. 3) Novel frontiers and brand-new technologies, for example, drug delivery devices for zero-order sustained release and stimuli responsive imprinted DDS. 4) Revolutionary impact on dermal delivery, ophthalmic drugs and cancer treatment. 5) Future challenges and perspectives.
    Type of Medium: Online Resource
    Pages: VII, 216 p. 108 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811602276
    URL: https://doi.org/10.1007/978-981-16-0227-6
    DOI: 10.1007/978-981-16-0227-6
    DDC: 615
    Language: English
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  • 2
    Electronic Resource
    Electronic Resource
    Late transition metal oxo and imido complexes. 11. Gold(I) oxo complexes (1993)
    s.l. : American Chemical Society
    Inorganic chemistry 32 (1993), S. 1946-1950 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00062a012
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  • 3
    Electronic Resource
    Electronic Resource
    New Gold Clusters [Au8L6](BF4)2 and [(AuL)4](BF4)2 (L = P(mesityl)3) (1994)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 116 (1994), S. 6983-6984 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00094a082
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  • 4
    Electronic Resource
    Electronic Resource
    Dehalogenation reactions in californium-252 plasma desorption mass spectrometry (1985)
    s.l. : American Chemical Society
    Analytical chemistry 57 (1985), S. 1771-1772 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac00285a063
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  • 5
    Electronic Resource
    Electronic Resource
    The Microstructure Evolvement and Simulation Analysis during Semi-Solid Processing of Aluminum Alloy (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 141-143 (July 2008), p. 139-144 
    Details
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Notes: To enhance the comprehension on the internal rule of microstructure evolvement andquality-controlled relativity, the microstructure during the induction reheating of billets and diecasting of parts was systematically investigated. According to general structure observation and aidedanalysis of some computer simulations, the quantitative relationships between microscopicmorphology (including solid fraction and grain shape) and formation state was minutely discussed.The experimental results showed that liquid and solid phase in semi-solid slurry had different fillingtendency, fluid velocity of liquid phase in the area of high filling speed was relative quick and easy toflow into far area and corner. Solid particles far from gate possessed fine and round grain. Moreover,the structure configuration of original billets markedly affected forming process; billets with fine andround grain were required for the die-castings of complex shape and thin thickness. In the case of thebig change in shape and thickness of die-castings, the design of gating system and the control ofplunger speed should be so properly carried out as to avoid unequal distribution of solid and liquidphase in die-casting part as soon as possible
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/24/transtech_doi~10.4028%252Fwww.scientific.net%252FSSP.141-143.139.pdf
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  • 6
    Electronic Resource
    Electronic Resource
    On non-Kählerianity of nonuniform lattices¶in SO(n, 1)(n≥ 4) (2000)
    Springer
    Manuscripta mathematica 103 (2000), S. 401-407 
    Details
    ISSN: 1432-1785
    Keywords: Mathematics Subject Classification (2000): 14E20, 58E20
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract: In this note, we will show that no nonuniform lattice of SO(n, 1)(n≥ 4) is the fundamental group of a quasi-compact Kähler manifold
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002290070014
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  • 7
    Electronic Resource
    Electronic Resource
    Isolation of the 5′ region of the human ITGB7 integrin gene (1994)
    Springer
    Immunogenetics 39 (1994), S. 375-376 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00189241
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  • 8
    Electronic Resource
    Electronic Resource
    IgG rheumatoid factors isolated by the surface-displaying phage library technique (1997)
    Springer
    Immunogenetics 45 (1997), S. 301-310 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Our analysis of IgG rheumatoid factors (RFs) from three patients with rheumatoid arthritis (RA) revealed that most contained significant numbers of skewed mutations per V region, suggesting that these RFs arose from antigen-driven responses. To further study IgG RFs in RA, we used pComb3 vector to construct an IgG1,λ combinatorial antibody library from a synovial fluid sample. After panning against human IgG, Fab fragments from 71/96 phage clones bound to Fc-coated wells. Sequence analysis of 20 randomly chosen Fc-binders showed that 17 (85%) clones had identical heavy (H) and light (L) chain V regions, represented by Humha311 and Humla211, respectively. Of the remaining three clones, two had the same Humla211 L chain, but each with a different H chain V region. All the putative germline V genes for these RFs also encode RF in RA patients. However, none of these RF V regions are similar to those of the two IgG RFs derived by the hybridoma technique from the same synovial fluid. The Humha311 H chain has two frameshifts: a one-base insertion upstream of the JH region and a four-base deletion near the end of the CH1 region, resulting in a mainly unconventional amino acid sequence in the CH1 region. In the future, it will be important to study the presence of IgG molecules with such unconventional CH1 amino acid sequences, and the effects of these amino acid sequences on the structures and immunological properties of the IgG molecules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050209
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  • 9
    Electronic Resource
    Electronic Resource
    Study on the Reactivity Activation of Steel Slag through Autoclaving Curing (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 334-335 (Mar. 2007), p. 525-528 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Feasibility study of partially replacement of cement and ground sand by ground steel slag (GSS)and ground granulated blast furnace slag (GGBFS) in producing prestressed high strength concretepile (PHC) was conducted. The results showed that under normal curing（20oC, 95% RH）and thesteam curing condition (80oC), GSS possessed less reactivity than GGBFS. However, underautoclave curing condition (180 ℃, 1.0MPa), the reactivity of GSS can be effectively activated. Theautoclaving strength of the concrete made from 20% GSS with Blaine 550m2/kg, 55% cement and25% ground sand could reach 89.0 MPa which is not only higher than that of GGBFS (82.8MPa),but also higher than that of traditional PHC concrete (83.9Mpa, 70% cement and 30% ground sand).It’s feasible to produce PHC concrete by GSS with high fineness and optimized dosage
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.334-335.525.pdf
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  • 10
    Electronic Resource
    Electronic Resource
    Machining Characteristics of Semibonded Abrasive Grinding Plate (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 53-54 (July 2008), p. 173-178 
    Details
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This work aims to obtain fine surface of silicon wafer during precision and ultra precisionmachining, and presents a new method called semibonded abrasive machining. A semibondedabrasive grinding plate is used in the semibonded abrasive machining. Abrasive particle of 1000#Green SiC and bond named SSB are adopted in the manufacture of the plate. Four plates withdifferent concentration of bond which are 1.5%, 2.5%, 3.5%, 4.5% respectively are made. The paperstudies the effect of concentration of bond, the control parameters which include the lapping time, theload, and the rotating velocity of the plate on the surface roughness. Experimental results indicateeach plate with different concentration of bond can obtain fine surface roughness. When the load orthe rotating velocity increases, there is little effect on the surface roughness, but the materialremoval rate increases correspondingly. The initial roughness of the silicon wafer surface lappingby the plate could be improved from Ra 0.2μm to Ra 0.02μm in 9 min
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/41/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.53-54.173.pdf
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