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  • 1
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    Outline of a joint research project by ENEL-INGV for the study of the microseismicity in the Larderello geothermal area (2007)
    Details
    Publication Date: 2017-04-04
    Description: The Larderello geothermal field is located ca. 100 km southeast of Florence, in the northern part of a volcanic zone that extends along the Italian Tyrrhenian coast. Geophysical investigations in the area suggest a crustal thinning and an injection of hot material from the upper mantle into the crust.
    Description: Published
    Description: Graz, Austria
    Description: 1.1. TTC - Monitoraggio sismico del territorio nazionale
    Description: open
    Keywords: Larderello ; geothermal area ; 04. Solid Earth::04.06. Seismology::04.06.06. Surveys, measurements, and monitoring
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: Oral presentation
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  • 2
    Electronic Resource
    Electronic Resource
    Structure of the detergent phase and protein-detergent interactions in crystals of the wild-type (strain Y) Rhodobacter sphaeroides photochemical reaction center (1991)
    s.l. : American Chemical Society
    Biochemistry 30 (1991), S. 9403-9413 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00103a003
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Thymine dimer repair in fibroblasts of patients with dysplastic naevus syndrome (DNS) (1988)
    Springer
    Cellular and molecular life sciences 44 (1988), S. 169-171 
    Details
    ISSN: 1420-9071
    Keywords: Dysplastic naevus syndrome ; DNA-repair ; cancer genes ; familial malignant melanoma ; monoclonal antibodies specific for UV-dimers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Dysplastic naevus syndrome (DNS) is frequently observed in association with familial melanoma and xeroderma pigmentosum (XP), but the role of UV-light in the development of DNS has not been elucidated. Previous work has shown that UV-induced unscheduled DNA synthesis is associated with the early loss of antigenicity observed in immunoassays using a monoclonal antibody specific for thymine-thymine dimers. We now show that the rate of loss of antigenicity, which reflects the relative amount of bound antibody, observed during the first 60 min following 10 Jm−2 UVC irradiation is significantly reduced (p=0.02) in cultures of fibroblasts from 7 out of 8 DNS patients compared with the results from cells of a group of 30 healthy volunteers. This observation suggests an early event in excision repair is altered in the majority of DNS patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01952205
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  • 4
    Electronic Resource
    Electronic Resource
    TCRB-V gene usage in monozygotic twins discordant for multiple sclerosis (1994)
    Springer
    Immunogenetics 39 (1994), S. 281-285 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00188792
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  • 5
    Electronic Resource
    Electronic Resource
    Mutations in the MHC class I-like candidate gene for hemochromatosis in French patients (1997)
    Springer
    Immunogenetics 45 (1997), S. 320-324 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  A candidate gene for hemochromatosis has recently been localized on the short arm of chromosome 6, about 4 megabases telomeric to the major histocompatibility complex. It encodes a protein that exhibits significant similarity to the HLA class I molecules and can be provisionally designated HLA-hc. Genotype analysis of 94 hemochromatosis patients living in France and a similar number of controls confirms that the disease is strongly associated with homozygosity at nucleotide 845 (72% of the patients and none of the controls carry two copies of the 845A variant). The data are consistent with hemochromatosis being a heterogeneous disease: about 79% of the cases in this sample would be caused by a defect in HLA-hc and 21% by an unrelated mechanism. A second variant (187 G) enriched on patient chromosomes that do not carry the 845A mutation might influence the affinity of a ligand for HLA-hc; the exact nature of this ligand remains to be discovered. The 845A variant is the best genetic marker for the disease identified to date, and the detection of 845A homozygosity should now permit diagnosis of a readily curable disease and the prevention of sometimes deadly complications in at least 72% of the patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050211
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  • 6
    Electronic Resource
    Electronic Resource
    Polymorphic tri and tetranucleotide repeats in exons 1 and 8 of the myelin oligodendrocyte glycoprotein (MOG) gene (1995)
    Springer
    Human genetics 〈Berlin〉 96 (1995), S. 737-738 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Polymorphic (CTC)n and (TAAA)n sequences were identified in exons 1 and 8 of the myelin oligodendrocyte glycoprotein (MOG) gene. The different alleles were detected by a method combining fluorescence labeling of polymerase chain reaction (PCR) products and use of an automated DNA sequencer. Although only two alleles differing by the number of leucine residues encoded by the (CTC)n array were detected at the first locus, seven alleles were identified at the second. The high degree of polymorphism (75%) of the tetranucleotide repeat makes this marker informative for association or linkage studies with diseases such as hemochromatosis or multiple sclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00210310
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  • 7
    Electronic Resource
    Electronic Resource
    Absence of the hemochromatosis gene Cys282Tyr mutation in three ethnic groups from Algeria (Mzab), Ethiopia, and Senegal (1997)
    Springer
    Immunogenetics 46 (1997), S. 222-225 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  A Celtic origin for hemochromatosis, a common genetic iron metabolism disorder, has been postulated for a long time. To check whether the two mutations recently identified in the HLA-class I candidate gene for this disease were found only in Caucasians, we examined their frequencies in individuals originating from Algeria, Ethiopia, and Senegal. The presumably disease-causing mutation, responsible for the Cys282Tyr substitution, was not found in any member of these ethnic groups, although it was shown to be highly prevalent in populations of European ancestry. This geographic distribution supports the previously suggested Celtic origin for the disease. In contrast, the mutation responsible for the His63Asp substitution is not restricted to European populations. Although absent in the Senegalese, it was found on about 9% of the chromosomes of the Central Ethiopians and Algerians (Mzab) genotyped for this study. This second mutation, which probably represents a common variant unrelated to hemochromatosis, thus appears to have occurred earlier than that responsible for the Cys282Tyr substitution. More detailed population studies are needed to provide information on the age of these two mutations and eventually show how the hemochromatosis-causing mutation chronologically spread throughout Europe.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050265
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  • 8
    Electronic Resource
    Electronic Resource
    Influence of compost and lime on population structure and element concentrations of forest soil invertebrates (1993)
    Springer
    Biology and fertility of soils 15 (1993), S. 165-173 
    Details
    ISSN: 1432-0789
    Keywords: Organic fertilization ; Lime ; Element concentrations ; Compost ; Microarthropods ; Lumbricidae ; Lumbricus rubellus ; Acari ; Collembola ; Soil acidification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary We tested the effects of two organic fertilizers (composts) and lime on the soil fauna of a spruce stand. One compost was obtained from chopped wood and the other from household garbage. At the time of distribution the pH of the control plots averaged 3.2, the garbage compost had a pH of 7.5, and the wood compost of 6.2. During the experimental period the pH of the compost layers decreased. The pH of the former litter layer beneath the composts showed a steep increase after 5 months, but beneath the treatment with wood compost this effect did no persist. Liming increased the pH only slightly in the litter layer. The two types of compost, the litter layer, and lumbricids (Lumbricus rubellus) were analyzed for concentrations of essential and potentially toxic elements. The element burden was highest in the garbage compost with 7- to 11-fold concentrations of Zn, Cd, Pb, Mg, and Cu compared to the needle litter. K, Ba, and Ca were 4 times more concentrated. L. rubellus showed an increased Cu concentration after extraction from the highly contaminated sites of garbage compost. Despite the differences in Pb contamination in the needle litter and in the two compost types, all investigated individuals of L. rubellus contained similar concentrations of Pb. In contrast to Pb, Cd accumulated in this lumbricid. Seasonal fluctuations of microarthropods, their total abundance, and differences in the colonization of the compost layers were observed. Collembola abundance was significantly increased in the garbage compost plots in July 91. There were generally more Prostigmata in the control and limed plots than in the compost plots. Oribatid numbers fell under all treatments compared to the controls. Mesostigmata were identified to species level and 33 species were found in the experimental areas. Certain species, such as Arctoseius cetratus and Uropoda minima, were only found in the treated sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00361606
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  • 9
    Electronic Resource
    Electronic Resource
    Acetylator phenotype and congenital malformations (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 151-153 
    Details
    ISSN: 1432-1041
    Keywords: pharmacogenetics ; acetylator phenotype ; congenital anomalies/-heart disease ; facial cleft ; spina bifida
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The hypothesis has been tested that an unusual maternal acetylator phenotype can predispose to congenital malformations in the fetus. The acetylator phenotype of normal caucasian control women and of mothers of malformed children was established by measuring urinary sulphadimidine and its acetylated metabolite. A further control group was the fathers of the malformed newborn. The malformations studied were facial cleft, spina-bifida and congenital heart disease. The acetylator phenotype was shown not be modified by pregnancy. 49 of 100 (49%) control women were rapid acetylators. Amongst the 108 mothers of malformed babies, 56 (52.8%) were slow acetylators and 52 (47.2%) were fast acetylators, 42 out of 83 (50.5%) of the fathers of malformed were slow acetylators and 41 (49.5%) were fast acetylators. Thus, the acetylator phenotype of the mothers of malformed children is no different from the acetylator phenotype of controls.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609187
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  • 10
    Electronic Resource
    Electronic Resource
    Thermo-Mechanical Fatigue Behaviour of the Gamma-Titanium Aluminide TNB-V5 with Near-Gamma Microstructure (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 539-543 (Mar. 2007), p. 1559-1564 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The efficiency of aircraft and industrial gas turbines and combustion engines depends onthe maximum operation temperature and, therefore, on the properties of the commercial hightemperature materials. In the temperature range 500°C to 750°C γ-titanium aluminides especiallyalloys of the third generation represent an attractive alternative to the established nickel-basesuperalloys which have the double density. Due to superimposed cyclic thermal and cyclicmechanical loadings during start-up and shut-down operations structural components in gas turbinesand combustion engines may not only be exposed to isothermal but also to thermo-mechanical fatigue(TMF). In this study the cyclic deformation and fatigue behaviour under thermo-mechanical load ofthe γ-TiAl alloy TNB-V5 with near-gamma microstructure is evaluated. To set a fatigue-life relationstrain-controlled thermo-mechanical fatigue tests were carried out with two different strain ranges,different temperature-strain cycles and different temperature ranges from 400°C to 800°C. Additionallow-cycle fatigue (LCF) tests were performed at 400°C, 600°C and 800°C for comparison. Cyclicdeformation curves, stress-strain hysteresis loops and fatigue lives of the tests are presented. Theshortest fatigue lives are always observed in out-of phase (OP) tests, the longest in in-phase (IP) tests.Clockwise-diamond (CD) and counter-clockwise diamond (CCD) testing yield similar fatigue livesintermediate between those of OP and IP tests. For a general life prediction the double-logarithmicplot of the damage parameter by Smith, Watson and Topper vs. fatigue life is well suitable
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/15/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.539-543.1559.pdf
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