ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
α- and β-thyrocalcitonic isolated from pig thyroids were found to be single-chain polypeptides with 32 amino acid residues containing a disulphide bridge. Tryptic digestion yielded inactive hepta-, undeca-and tetradecapeptides, the amino acid composition of which is given. β-thyrocalcitonin proved to be the methionine sulphoxide derivative of the easily oxidizable methionine peptide α-thyrocalcitonin; thus, the designation β can be eliminated. Both peptides have a potency of about 200 MRC units/mg dry weight. They can readily be differentiated by their electrophoretic and chromatographic properties, as well as by their tryptic undecapeptide, whereas the hepta- and tetradecapeptides, respectively, produced by trypsin are identical.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19680510125
Permalink