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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 46 (1990), S. 1180-1185 
    ISSN: 1420-9071
    Keywords: Oxygen transfer ; tissue hypoxia ; mitochondria ; respiration, cellular ; diffusion, intracellular ; adaptation to hypoxia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Studies of O2 supply in freshly isolated adult mammalian cells provide new insight into the factors that limit mitochondrial oxygenation in vivo. Of particular importance, mitochondria are present at high densities and often in apparent clusters, both of which contribute to local O2 gradients under hypoxic conditions. Current evidence indicates that the mitochondrial distribution is a component of the differentiated phenotype of adult mammalian cells and that specific motors and anchoring mechanisms are present to allow redistribution in response to developmental, physiological and pathological challenges. To compare the importance of resistance to O2 transfer under different conditions and at different sites along the supply path in vivo, a simple mathematical expression of relative resistance to O2 supply is introduced. Under various pathophysiological conditions, this resistance increases in specific regions of the pulmonary, circulatory of cellular supply path and results in O2 deficiency in the mitochondria. Regardless of cause, the relative resistance increases dramatically in the vicinity of mitochondrial clusters during hypoxia.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Nutrition 12 (1992), S. 327-343 
    ISSN: 0199-9885
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Nutrition 9 (1989), S. 229-251 
    ISSN: 0199-9885
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 48 (1986), S. 33-50 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 317 (1985), S. 824-828 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 Response of ?-globin (G) and adenovirus-2 major late promoter (Ad) transcription to the K562 nuclear extract. The products of the in vitro transcription reaction were electophoresed in formaldehyde-containing gels. The upper band is the ?-globin transcript, 622 bases long, and the lower is ...
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    International journal of fracture 11 (1975), S. 897-914 
    ISSN: 1573-2673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Résumé L'influence de la fermeture de la fissure et de l'écoulement élastoplastique sur le comportement à la flexion de tôles minces fissurées, est étudiée en faisant appel à un programme de calcul par éléments finis de la flexion incrémentielle de la tôle en régime élastoplastique. Le programme d'éléments finis a été développé en recourant à des hypothèses satisfaisant la théorie des plaques du quatrième ordre de Kirchhoff; les propriétés mécaniques considérées pour le matériau permettent, par ailleurs, de considérer un écrouissage général isotrope, avec réactions élastiques locales lors du déchargement. Cette technique a été appliquée au problème d'une grande tôle circulaire traversée en son centre par une fissure et soumise à flexion pure en son pourtour. On établit la comparaison de deux cas types du problème de flexion: le premier, où l'on néglige la possibilité d'interférence des faces de la fissure avec le moment de flexion, et le second, où l'on introduit un obstacle cinématique au passage de la fissure au travers du plan de symétrie. Les résultats rapportés isolent les effets de l'écoulement élastoplastique et de la fermeture de la fissure.
    Notes: Abstract The influence of crack closure and elasto-plastic flow on the bending behavior of thin cracked plates is investigated through use of an incremental elasto-plastic plate bending finite element computer program. The finite element program was developed using assumptions consistent with Kirchhoff fourth order plate theory while the material property treatment permits general isotropic work hardening with local elastic unloading. This technique is applied to the problem of a large centrally through cracked plate subject to remote circular bending. Comparison is drawn between two cases of the bending problem. The first neglects the possibility of crack face interference with bending, and the second includes a kinematic prohibition against the crack face from passing through the symmetry plane. Results are reported which isolate the effects of elasto-plastic flow and crack closure.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    International journal of fracture 81 (1996), S. 89-97 
    ISSN: 1573-2673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Alternative stress intensity factor solutions are developed for several common fatigue crack propagation specimens. Unlike the K-solutions presently employed, the K-solutions developed herein allow direct integration of the Paris fatigue crack growth rate power law while retaining the same degree of accuracy.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Cell Motility and the Cytoskeleton 11 (1988), S. 106-116 
    ISSN: 0886-1544
    Keywords: stembody ; microtubules ; phosphorylation ; midbody ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Phosphorylated proteins have been implicated in the control and regulation of many cellular events. One of the striking features of microtubule organizing centers is that they are rich in phosphoproteins [Vandre et al., 1984]. In this report we describe the application of electron spectroscopic imaging to the study of the spatial and temporal distribution of phosphorus and hence to the study of phosphorylated proteins associated with the formation and organization of one such organizing center, the intercellular bridge. Our study indicates that there are several discrete microtubule-based domains that ultimately come to lie within the intercellular bridge and that there is a unique pattern of phosphorylation-dephosphorylation in some of these domains. These patterns correlate with the concurrent growth and sliding of antiparallel microtubules and the development of interactions among neighboring microtubules.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 17 (1979), S. 365-370 
    ISSN: 1741-0444
    Keywords: Fluorophotometer ; Ophthalmology ; Tear turnover
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The use of fluorescein dye for the study of ocular dynamics in ophthalmology is briefly reviewed. General principles for designing objective fluorophotometers for measuring the rate of change of fluorescein concentration are discussed. Details of the circuitry and performance of a new improved objective fluorophotometer using a quartz-halogen excitation source and a synchronous detector are presented. In a preliminary clinical trial the mean tear turnover rate for ten normal subjects was found to be 21±13% min−1.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1741-0444
    Keywords: Forced-expiration measurement ; Pressure-transistor ; Ventilatory capacity ; Venturi-pneumotachography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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