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  • 1
    Electronic Resource
    Electronic Resource
    Clean conditions for the determination of ultra-low levels of mercury in ice and snow samples (2000)
    Springer
    Fresenius' journal of analytical chemistry 366 (2000), S. 433-437 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Laboratory facilities and methods are presented for the determination of ultra-low levels of mercury (Hg) in ice and snow samples originating from polar ice caps or temperate regions. Special emphasis will be given to the presentation of the clean laboratory and the cleaning procedures. The laboratory is pressurized with air filtered through high efficiency particle filters. This first filtration is not enough to get rid of contamination by Hg in air. Experiments are conducted in a clean bench, especially built for Hg analysis, equipped with both particle filter and activated charcoal filter. It allows to obtain very low levels of atmospheric Hg contamination. Ultrapure water is produced for cleaning all the plastic containers that will be used for ice and snow samples and also for the dilution of the standards. Hg content in laboratory water is about ¶0.08 ± 0.02 pg/g. A Teflon system has been developed for the determination of Hg in ice and snow samples based on Hg(II) reduction to Hg(0) with a SnCl2/HNO3 solution followed by the measurement of gaseous Hg(0) with a Hg analyzer GARDIS 1A+ based on the Cold Vapor Atomic Absorption Spectroscopy method. Blank determination is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160050088
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of loperamide, a peripheral opiate agonist, on circulating glucose, free fatty acids, insulin, C-peptide and pituitary hormones in healthy man (1981)
    Springer
    European journal of clinical pharmacology 21 (1981), S. 185-188 
    Details
    ISSN: 1432-1041
    Keywords: loperamide ; opiate agonist ; pituitary hormones ; glucose ; free fatty acids ; insulin ; C-peptide ; metabolic effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of acute oral administration of loperamide (4, 8 and 16 mg), a peripheral opiate agonist used in the treatment of diarrhoea, on several metabolic and endocrine variables has been evaluated in healthy volunteers in comparison with placebo. Plasma glucose was significantly raised by all three doses, whereas serum IRI and C-peptide were decreased and serum FFA was significantly increased only after loperamide 8 and 16 mg; serum PRL, GH, LH and FSH did not change. The data suggest that opiates may be involved in the regulation of glycaemia, probably by modifying islet hormone secretion by acting at a peripheral site, since loperamide does not cross the blood-brain barrier. Although the precise mechanism of these actions is unknown, it is suggested that the effects of loperamide are mediated either by stimulation of opiate receptors per se, or by suppression of acetylcholine release from cholinergic nerve endings. The lack of change in pituitary hormone secretion by loperamide is in agreement with previous observations indicating that opiate effects on PRL, GH and gonadotropins occur at the level of the central nervous system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00627918
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of dihydroergokryptine administration on serum prolactin and growth hormone levels in normal, hyperprolactinaemic and acromegalic subjects: Evidence of potent and long-lasting pituitary dopamine receptor stimulation (1985)
    Springer
    European journal of clinical pharmacology 27 (1985), S. 707-711 
    Details
    ISSN: 1432-1041
    Keywords: dihydroergokryptine ; acromegaly ; hyperprolactinaemia ; prolactin ; growth hormone ; l-DOPA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The endocrine effects of a relatively potent dopaminergic agent, dihydroergokryptine, have been studied in normal subjects, and in hyperprolactinaemic and acromegalic patients. A single 6 mg oral dose of the drug caused a marked, long lasting fall in prolactin (PRL) plasma levels in healthy subjects, in hyperprolactinaemic patients and in normoprolactinaemic acromegalics. Growth hormone (GH) levels decreased in l-DOPA — responder, acromegalic patients, but dihydroergokryptine did not affect GH levels in normal volunteers or in l-DOPA non — responder, acromegalic patients. The PRL-and GH- lowering activity of 6 mg dihydroergokriptine was significantly greater than that of 6 mg dihydroergocristine, and was similar to that of an oral dose of 500 mg l-DOPA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00547054
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of FCE 20700, a new PGE2 derivative, on gastric acid secretion and cytoprotective processes in man (1987)
    Springer
    European journal of clinical pharmacology 31 (1987), S. 535-539 
    Details
    ISSN: 1432-1041
    Keywords: FCE20700 ; gastric secretion ; antisecretory activity ; mucoprotein release ; bicarbonate release ; serum gastrin ; healthy volunteers ; PGE2 derivative ; cytoprotection ; side-effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacodynamic effects of FCE20700, a new PGE2 derivative, have been investigated in 6 healthy volunteers given single intragastric (i.g.) and intraduodenal (i.d.) doses of 1 and 2 mg and placebo, according to a double-blind, within — subjects design. For 30–270 min following i.g. administration the effect of FCE20700 on peptone-stimulated gastric acid secretion (AS) was assessed by i.g. titration, and serum gastrin (G) levels were also determined. For the same period after i.d. dosing the effect of the compound on pentagastrin-stimulated AS and on mucoproteins and bicarbonate content in the gastric juice was measured. Blood pressure (BP), heart rate and possible side-effects were monitored. Following i.g. administration there was a moderate, dose-related, significant inhibition of AS; significant inhibition of G levels was observed only after the highest dose. After i.d. administration there was a very modest through dose-related and significant inhibition of AS; a brief maximal increase in mucoproteins and in bicarbonate levels was apparent after the 1 mg dose. After i.d. but not after i.g. administration of 2 mg there was a modest but significant decrease in BP. No side-effects of clinical relevance were reported. The results appear to suggest a major activity of FCE20700 on cytoprotection rather than in inhibiting gastric acid secretion. The observed change in BP may indicate that after i.d. administration there will be some systemic effects of FCE20700.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00606626
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  • 5
    Electronic Resource
    Electronic Resource
    Improved oral glucose tolerance following antiserotonin treatment in patients with chemical diabetes (1979)
    Springer
    European journal of clinical pharmacology 15 (1979), S. 395-399 
    Details
    ISSN: 1432-1041
    Keywords: cyproheptadine ; metergoline ; glucose tolerance ; insulin secretion ; chemical diabetes ; man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of short-term treatment with either placebo or two serotonin antagonists, cyproheptadine and metergoline, on oral glucose tolerance and insulin secretion have been evaluated in normal subjects and in patients with chemical diabetes. Placebo treatment was not associated with any significant change in the parameters examined. Glucose tolerance in chemical diabetics was significantly improved both after cyproheptadine and metergoline; fasting plasma glucose was also reduced by metergoline. Treatment with the latter drug was also associated with a significant decrease in incremental glucose area in healthy subjects, which was not affected by cyproheptadine. Basal and glucose-stimulated insulin secretion were not affected by either drug in any subjects. Cyproheptadine and metergoline improve glucose metabolism in chemical diabetes probably by reducing insulin resistance. This may depend either on decreased secretion of counter-regulatory hormones or on a direct pharmacological action of the drugs on glucose utilization, possibly mediated by their common antiserotoninergic properties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561737
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of two antiserotoninergic drugs, methysergide and metergoline, on gastric acid secretion and gastrin release in healthy man (1980)
    Springer
    European journal of clinical pharmacology 17 (1980), S. 13-18 
    Details
    ISSN: 1432-1041
    Keywords: serotonin ; methysergide ; metergoline ; metoclopramide ; gastric acid secretion ; gastrin secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of acute oral administration of the antiserotoninergic drugs methysergide (3 mg) and metergoline (4 mg) on basal, submaximal (0.6 µg/kg i. m.) and maximal (6 µg/kg) pentagastrinstimulated gastric acid secretion, as well as on basal and food-induced gastrin release, have been evaluated in healthy volunteers. Methysergide significantly increased basal and submaximal pentagastrin-stimulated gastric acid secretion, and metergoline significantly inhibited gastric acidity in all experiments. Basal and stimulated serum gastrin concentrations were not modified by either drug. The effect of methysergide on gastric acid secretion was opposed to that of serotonin and was probably dependent on its antiserotoninergic action, but the decrease in gastric acidity caused by metergoline is not easily explained. Although the effect is similar to that of a dopamine infusion, it does not depend on dopamine receptor stimulation, since it was not influenced by pretreatment with metoclopramide. It is suggested that it might be due to the weak anticholinergic and/or antihistaminic properties of metergoline.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561671
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  • 7
    Electronic Resource
    Electronic Resource
    Simultaneous dielectric spectroscopy and calorimetry of the dynamics during a macromolecules growth (1996)
    Springer
    Il nuovo cimento della Società Italiana di Fisica 18 (1996), S. 1443-1448 
    Details
    ISSN: 0392-6737
    Keywords: Glass transitions ; Calorimetry ; Dielectric loss and relaxation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Summary A method and an instrument has been developed for measuring almost simultaneously and continuously in time three different quantities: i) the heat evolved during the course of exothermic reactions, ii) the heat capacity and iii) the dielectric spectra of a liquid or solid sample. By using this instrument, we have studied the decrease in the d.c. conductivity and the increase in the relaxation time as molecules in an isothermally kept liquid chemically react to produce, irreversibly, a macromolecular structure until the liquid vitrifies and becomes rigid. The number of covalent bonds formed in the structure,n, has been calculated and the dielectric relaxation time, τ, is related ton. This τ increases progressively more rapidly withn, and decreases, of course, on increasing the temperature. A compensation between these two effects determines the dynamic behaviour observed during rate heating. The effect of temperature is found to predominate. Such observations have been made possible by means of the new instrument.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02453785
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  • 8
    Electronic Resource
    Electronic Resource
    X-ray double-crystal rocking curves in GaAlAs/GaAs heterostructures (1991)
    Springer
    Il nuovo cimento della Società Italiana di Fisica 13 (1991), S. 1-14 
    Details
    ISSN: 0392-6737
    Keywords: Specific structures of elements and alloys
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Summary X-ray double-crystal rocking curves of Ga1−x Al x As/GaAs heterostructures have been calculated using a dynamical diffraction model for the general case of Bragg reflection geometry. Different experimental configurations have been considered and the possibility of studying both slightly mismatched and relatively thin layers has been investigated. Experimental rocking curves have been measured using the CuKα 1 radiation, the 004 symmetric reflection and a perfect crystal as the monochromator. An excellent agreement between calculated and experimental rocking curves has been found and this demonstrates the reliability of both the experimental procedure and the theoretical approach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02451270
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  • 9
    Electronic Resource
    Electronic Resource
    Review of conductor development for use in high-temperature superconducting cables (1994)
    Springer
    Il nuovo cimento della Società Italiana di Fisica 16 (1994), S. 2067-2072 
    Details
    ISSN: 0392-6737
    Keywords: Superconducting magnets and magnetic levitation devices ; superconducting cables and conductors ; Conference proceedings
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Summary This paper reviews and assesses the progress in conductor development across the world in advancing high-temperature superconducting science and technology towards the fabrication of superconducting transmission cables operating at 77 K. Materials, fabrication routes and the feasibility of high-temperature superconducting cables will be discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02471868
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  • 10
    Electronic Resource
    Electronic Resource
    A calorimeter for the electrolytic cell and other open systems (1996)
    Springer
    Il nuovo cimento della Società Italiana di Fisica 18 (1996), S. 1333-1346 
    Details
    ISSN: 0392-6737
    Keywords: Energy-conversion spectro-analytical methods (e.g., photoacoustic, photothermal, and optogalvanic spectroscopic methods) ; Calorimetry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Summary We present here a calorimetric method and the construction details of a differential calorimeter useful for studying the reactions in an electrolytic cell and more generally slow chemico-physical processes occurring in thermodynamically open systems. The method allows measurements of the heat balance of the cell, from which the enthalpy change of the process under investigation can be calculated. The theoretical description of the calorimetric cell and the results of several studies planned to describe the performances of the instrument up to the boiling point of the electrolytic solution are reported. The features of this calorimeter fulfil most of the requirements of ≪col fusion≫ experiments, where the heat production is the fundamental and controversial aspect. By controlling both the heat and the matter exchanged, the calorimeter can be utilised also to study bioenergetic processes,e.g. fermentation, microbial metabolism and biodegradation, and liquid phase chemical reactions, involving gases as reactants and/or products.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02453267
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