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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Medicine Research. ; Biology Research. ; Proteins . ; Biology Technique. ; Neuroscience. ; Biomedical Research. ; Protein Biochemistry. ; Biological Techniques.
    Description / Table of Contents: Chapter 1. Peroxisome: metabolic functions and biogenesis -- Chapter 2. Peroxisomal Dysfunction and Oxidative Stress in Neurodegenerative Disease: A Bidirectional Crosstalk -- Chapter 3. 7-hydroxycholesterols-induced peroxisomal disorders in glial and microglial cells: potential role in neurodegeneration -- Chapter 4. Peroxisome biogenesis disorders -- Chapter 5. Fatty Acid Oxidation in Peroxisomes: Enzymology, Metabolic Crosstalk with Other Organelles And Peroxisomal Disorders -- Chapter 6. Zellweger syndrome disorders: from severe neonatal disease to atypical adult presentation -- Chapter 7. Heimler Syndrome -- Chapter 8. Potential involvement of peroxisome in multiple sclerosis and Alzheimer’s disease -- Chapter 9. Developmental and degenerative cerebellar pathologies in peroxisomal β-oxidation deficiency -- Chapter 10. A mouse model system to study peroxisomal role in neurodegenerative diseases such as peroxisome biogenesis disorders -- Chapter 11. The Drosophila melanogaster as genetic model system to dissect the mechanisms of disease that lead to neurodegeneration in adrenoleukodystrophy -- Chapter 12. Human peroxisomal 3-keto-acyl-CoA thiolase: tissue expression and metabolic regulation -- Chapter 13. Biological functions of plasmalogens -- Chapter 14. Therapeutic efficacy of plasmalogens for Alzheimer’s disease, Mild Cognitive Impairment and Parkinson’s disease in conjunction with a new hypothesis for the etiology of Alzheimer’s disease.
    Abstract: This book provides an overview of the biology and biochemistry of peroxisomes, and discusses the contribution of these organelles to peroxisomal and neurodegenerative diseases. It begins with a detailed introduction to the biogenesis and metabolic functions of peroxisomes, and highlights their role in oxidative stress and in lipid metabolism such as fatty acid oxidation. The following chapters focus on the molecular and clinical aspects of peroxisomal disorders caused by defects in peroxisomal function. In particular, the biological aspects of peroxisomal biogenesis disorders such as Zellweger syndrome and Heimler syndrome are discussed. This includes their underlying genetic causes as well as the biochemical and metabolic defects associated with the disorders. In addition, several chapters cover recent observations suggesting an association between peroxisomal dysfunction and neurodegenerative diseases such as Alzheimer's, Multiple Sclerosis and other degenerative cerebellar pathologies. The final section of the book discusses important cell and animal models for studying the role of peroxisomes in human diseases and presents current therapeutic strategies for their treatment. This book deals with a highly topical subject that is at the heart of current research, and represents a valuable contribution for all students and researchers who want to understand the complex biology of peroxisomes and their role in human diseases.
    Type of Medium: Online Resource
    Pages: X, 212 p. 44 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030602048
    Series Statement: Advances in Experimental Medicine and Biology, 1299
    DDC: 612.8
    Language: English
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  • 2
    Keywords: Pharmacology. ; Pharmacy. ; Medical microbiology. ; Neurosciences. ; Pharmacology. ; Pharmacy. ; Medical Microbiology. ; Neuroscience.
    Description / Table of Contents: Part 1. Autonomic Nervous System -- Chapter 1. Cholinoceptor Agonists and Anticholinesterase Agents -- Chapter 2. Cholinoceptor Antagonists -- Chapter 3. Adrenergic Agonists -- Chapter 4. Adrenergic Antagonists -- Part 2. Central and Peripheral Nervous System -- Chapter 5. Neurotransmitters and Neurotransmission. Chapter 6. Hypnotics and Sedatives -- Chapter 7. Pharmacotherapy of Seizures -- Chapter 8. General Anesthetics -- Chapter 9. Drug Therapy of Psychosis and Mania -- Chapter 10. Pharmacotherapy of Depression and Anxiety Disorders Chapter 11. Pharmacotherapy of Neurodegenerative Disorders -- Chapter 12. Opioid Agonists and Antagonists -- Chapter 13. Cognition enhancers, Psychostimulants and Psychedelic Drugs -- Chapter 14. Drug Dependence and Abuse -- Chapter 15. Local Anesthetics -- Chapter 16. Skeletal muscle relaxants. Part 3. Autacoids and Other Chemical Mediators -- Chapter 17. Histamine, Serotonin, Bradykinin, and the Ergot Alkaloids -- Chapter 18. Prostaglandins, Leukotrienes and Related Compounds -- Chapter 19. Non-Steroidal Anti-Inflammatory Medicines -- Chapter 20. Drugs Used in Rheumatoid Arthritis -- Chapter 21. Pharmacotherapy of Gout -- Chapter 22. Nitric oxide, Vasoactive Peptides and Purines -- Part 4. Cardiovascular and Renal Pharmacology -- Chapter 23. Drugs Affecting Renal Excretory Function -- Chapter 24. Antihypertensive Agents -- Chapter 25. Treatment of Ischemic Heart Disease -- Chapter 26. Drugs Used in Heart Failure -- Chapter 27. Drugs Used in Cardiac Arrhythmias -- Chapter 28. Pharmacotherapy of Shock and Drugs Used in Cardiopulmonary Resuscitation -- Chapter 29. Treatment of Pulmonary Arterial Hypertension -- Chapter 30. Antiplatelets, Anticoagulants and Fibrinolytics -- Chapter 31. Drugs Used in Dyslipidemias -- Part 5. Pulmonary Pharmacology -- Chapter 32. Treatment of Asthma and COPD -- Chapter 33. Drugs Used in Cough and Rhinitis -- Part 6 Gastrointestinal Pharmacology -- Chapter 34. Drugs Used in Acid-Peptic Disorders -- Chapter 35. Drugs Affecting Gastrointestinal Motility -- Chapter 36. Antiemetics -- Chapter 37. Drug Therapy for Constipation -- Chapter 38. Antidiarrheal Agents -- Chapter 39. Irritable Bowel Syndrome -- Chapter 40. Pharmacotherapy of Inflammatory Bowel Disease -- Chapter 41. Miscellaneous Drugs Acting on the Gastrointestinal System -- Part 7. Endocrine Pharmacology -- Chapter 42. Hypothalamic and Pituitary Hormones -- Chapter 43. Pharmacotherapy of Diabetes Mellitus -- Chapter 44. Thyroid and Antithyroid Drugs -- Chapter 45. Adrenocorticosteroids and Their Antagonists -- Chapter 46. Gonadal Hormones and Their Inhibitors -- Chapter 47. Pharmacotherapy of Obesity -- Chapter 48. Drugs Affecting Bone Mineral Homeostasis -- Part 8. Hematopoietic System -- Chapter 49. Pharmacotherapy of Iron Deficiency and Other Related Anaemias -- Chapter 50. Pharmacotherapy of Vitamin B12 and Folic Acid Deficiency -- Chapter 51. Drug-Induced Blood Dyscrasias -- Part 9. Chemotherapy of Microbial Diseases -- Chapter 52. General Principles of Antimicrobial Therapy -- Chapter 53. Sulfonamides, Quinolones and Agents For Urinary Tract Infections -- Chapter 54. Penicillins, Cephalosporins and Other β-Lactam Antibiotics -- Chapter 55. Protein Synthesis Inhibitors -- Chapter 56. Antimycobacterial Drugs -- Chapter 57. Antifungal Drugs -- Chapter 58. Antiviral Drugs -- Chapter 59. Miscellaneous Antimicrobial Agents -- Chapter 60. Chemotherapy of Malaria and Other Protozoal Diseases -- Chapter 61. Chemotherapy of Helminthiasis -- Part 10. Pharmacotherapy of Neoplastic Disease -- Chapter 62. General Principles of Cancer Chemotherapy -- Chapter 63. Cytotoxic Drugs -- Chapter 64. Targeted Chemotherapy -- Chapter 65. Hormones Agents in the Pharmacotherapy of Cancer -- Chapter 66. Immunopharmacology -- Chapter 67. Dermatological Pharmacology -- Chapter 68. Ocular Pharmacology -- Chapter 69. Nutritional Supplements and Herbal Medicines -- Chapter 70. Immunoglobulins and Vaccines. .
    Abstract: This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences. .
    Type of Medium: Online Resource
    Pages: XXIV, 1175 p. 152 illus., 117 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813360099
    DDC: 615
    Language: English
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  • 3
    Call number: PIK N 076-99-0291
    In: Scientific assessment of the ozone depletion
    Type of Medium: Monograph available for loan
    ISBN: 9280717227
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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  • 4
    Monograph available for loan
    Monograph available for loan
    Brüssel
    Associated volumes
    Call number: MOP Per 38(64)
    In: Publications
    Type of Medium: Monograph available for loan
    Series Statement: Etude hydrométéorologique des précipitations sur les bassins hydrographiques Belges / Franz Bultot 1
    Location: MOP - must be ordered
    Branch Library: GFZ Library
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  • 5
    Call number: PIK N 531-07-0272
    Type of Medium: Monograph available for loan
    ISSN: 1138-7424
    Series Statement: LUCC Report Series 3
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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  • 6
    Call number: 11/M 07.0078
    In: Theory and applications of transport in porous media
    Description / Table of Contents: Contents: Soil Mechanics.- Flow and Transport in Porous Media.- Complete Bibliography of Scientific Publications.
    Type of Medium: Monograph available for loan
    Pages: xi, 362 S. , ill
    ISBN: 1402035365
    Series Statement: Theory and applications of transport in porous media 19
    Classification:
    Soils
    Location: Reading room
    Branch Library: GFZ Library
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  • 7
    Call number: PIK N 076-99-0292
    In: Scientific assessment of the ozone depletion
    Type of Medium: Monograph available for loan
    ISBN: 9280717227
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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  • 8
    Series available for loan
    Series available for loan
    Hanover, NH : U.S. Army Cold Regions Research and Engineering Laboratory
    Associated volumes
    Call number: ZSP-201-82/24
    In: CRREL Report, 82-24
    Description / Table of Contents: Velocity data derived from petroleum industry seismic records from Harrison Bay show that high-velocity material ( or = 2 km/s) interpreted to be ice-bonded permafrost is common. In the eastern part of the bay, the depth to high velocity material increases and velocity decreases in an orderly manner with increasing distance from shore until the layer is no longer apparent. The western part of the bay is less orderly, possibly reflecting a different geological and thermal history. This western part may be an inundated section of the low coastal plain characterized by the region north of Teshekpuk Lake, and could have contained deep thaw lakes, creating low velocity zones. Along some seismic lines, the high-velocity material extends approximately 25 km offshore. Two anomalies have been found which could be associated with rapidly degrading permafrost. One is strong attenuation, which was interpreted as an indication of gas in the shallow deposits. The other is the presence of considerable seismic noise, including identifiable small seismic events. The origin of this noise has not been positively established, and it is proposed that it may indicate that some movement is occurring in the sediments due to thaw.
    Type of Medium: Series available for loan
    Pages: 65 Seiten , Illustrationen
    Series Statement: CRREL Report 82-24
    Language: English
    Note: CONTENTS Abstract Preface Introduction Methods Reading records Refractions Reflections Rayleigh waves Spatial resolution Anomalies Results and discussion Seismic velocity distribution Attenuation Low-level natural seismicity Summary Literature cited Appendix A: Error estimates Appendix B: Velocity profiles Appendix C: Seismic cross sections
    Location: AWI Archive
    Branch Library: AWI Library
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  • 9
    Series available for loan
    Series available for loan
    Hanover, NH : U.S. Army Cold Regions Research and Engineering Laboratory
    Associated volumes
    Call number: ZSP-201-81/2
    In: CRREL Report, 81-2
    Description / Table of Contents: Abstract: Many hyperbolic reflections have been observed on marine seismic records obtained during oil exploration in the Beaufort Sea, and on USGS seismic sub-bottom profiles from the Prudhoe Bay vicinity. A hyperbolic projection system was designed to rapidly measure seismic velocities from the curves on the records. The velocities observed were approximately the velocity of sound in water. The hyperbolic signals also showed dispersion properties similar to acoustic normal modes in shallow water. These observations indicate that the signals responsible for the hyperbolic reflections propagate as normal modes within the water layer, with very limited penetration of the seabed. Determinations of the dominant frequency of these signals indicate that the penetration into the seabed has a characteristic attenuation depth (skin depth) of about 1.5 m for the sub-bottom profiles and 12 m for the marine records. It therefore appears that some hyperbolic reflections may be generated by variations in materials that occur near the seabed. There is some evidence of linearity of the anomalies, possibly related to sediment-filled or open ice gouges, or other changes in material properties at shallow depths.
    Type of Medium: Series available for loan
    Pages: iv, 16 Seiten , Illustrationen
    Series Statement: CRREL Report 81-2
    Language: English
    Note: CONTENTS Abstract Preface Introduction Methods of analysis Marine seismic records Seismic sub-bottom profiles Results and discussion Distribution of hyperbolic reflections Hyperbolas on oil exploration records Hyperbolas on sub-bottom profiles Conclusions Literature cited Appendix A: Hyperbola projector
    Location: AWI Archive
    Branch Library: AWI Library
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  • 10
    Monograph available for loan
    Monograph available for loan
    Cheltenham [u.a.] : Elgar
    Call number: PIK B 010-16-90322
    Description / Table of Contents: After a long period of suburbanization, cities have been in vogue again since the 1980s. But why are people prepared to spend far more money on a small house in the city centre than on a large house in the countryside - and why doesn't this apply to all cities? The authors of this book argue that the appeal of the city in the 21st century is not only determined by the production side of the economy, but also by the consumption side: its array of shops, cultural activities and, for example, an historic city centre. All these factors translate into a huge disparity in land prices as well as different wages for urban and rural citizens. This study maps out these variations, with an economic approach to spatial planning and an emphasis on land rents as a basis for cost-benefit analysis. The use of land prices as a reflection of the appreciation for urban amenities is an ideal measurement tool in the cost-benefit analyses for local investments and spatial planning policies, and sheds new light on the organisation of public administration. This accessible book will be of interest to geographers, economists and social scientists, as well as policymakers involved in urban planning, seeking an in-depth understanding of land prices and the increasing importance of cities in the 21st century
    Type of Medium: Monograph available for loan
    Pages: VII, 135 Seiten , Illustrationen, Diagramme, Karten
    ISBN: 9781784717438 , 9781784717445 (electronic)
    Language: English
    Note: Contents: 1. The resurrection of the city -- 2. Land underneath the city -- 3. The dynamics of the Dutch system of cities -- 4. The production city -- 5. The consumer city -- 6. Land prices and governmental policy -- 7. Agglomeration benefits and spatial planning policy -- 8. Social cost-benefit analysis of an inner city transformation project -- 9. Agenda for the future
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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