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  • 1
    Electronic Resource
    Electronic Resource
    Gap junction formation between normal and reaggregated endoderm cells ofXenopus laevis neurulae (1982)
    Springer
    Development genes and evolution 191 (1982), S. 143-148 
    Details
    ISSN: 1432-041X
    Keywords: Amphibia ; Junctions ; Interaction ; Development ; Freeze fracture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Using freeze-fracture electron microscopy and fluorescent dye injection we have analysed the contacts between cells of the deeper endoderm taken from neurulae ofXenopus laevis. Endodermal cells in situ have large 1.5 μm diameter gap junctions composed of 8 nm P-face particles and corresponding E-face pits. Beside gap junctions, particle aggregates typical of desmosomal plaques are present but there are no tight junctions. The dissociation of endoderm into single cells involves profound structural alterations in the surface membrane including the complete disappearance of junctional structures among them gap junctions. The reaggregation of endoderm cells leads to the restoration of the surface membrane IMP (Intra Membrane Particle) pattern and, after ca. 30 min, to the establishment of functional pathways allowing for the intercellular transfer of fluorescent dye. Concomitantly gap junctions reappear. The observation that the dissociation and reaggregation of endodermal cells involves IMP alterations which go beyond the cell junctions themselves is discussed as an adaptation of the plasma membrane to changing environmental conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848328
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  • 2
    Electronic Resource
    Electronic Resource
    Quantitative description of end plate current and its reconstruction (1977)
    Springer
    Biological cybernetics 26 (1977), S. 125-129 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract An attempt was made to quantify the postsynaptic current based on the experimental data of the voltage clamp method. The conductance change in postsynaptic membrane was derived from the postsynaptic conductance of voltage clamped postsynaptic membrane, then it's temporal characteristics and dependence on the clamped voltage have been quantified. The temporal characteristics was found to be explained by the introduction of two schematic operators, active and inactive. This idea was applied to a simple electrical circuit model of the postsynaptic cells. Besides the change in postsynaptic potentials of normal synapse in excitable state was culculated as its application.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00365223
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  • 3
    Electronic Resource
    Electronic Resource
    Circadian influence on effect of propranolol on exercise-induced tachycardia in healthy subjects (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 133-137 
    Details
    ISSN: 1432-1041
    Keywords: propranolol ; chronopharmacology ; exercise-induced tachycardia ; pharmacokinetics ; healthy volunteers ; gastio-intestinal absorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Following a cross-over design propranolol 20 mg p.o. was given to 7 healthy subjects at 09.00 h and 21.00 h at an interval of 1 week. Heart rate (HR) during submaximal ergometer exercise was measured at four intervals during 10 h after treatment. Plasma propranolol concentrations were also determined. The suppressive effect (%R) of propranolol on the rise in HR during exercise after the morning dosage was significantly greater at 1.5 h and tended to be greater 3 h after administration than at comparable times in the evening trial. Mean plasma propranolol concentrations during the early phase were higher after the morning than the evening dose. The maximum plasma concentration (Cmax), area under the plasma concentration-time curve from 0 to 10 h (AUC (0–10)) and absorption rate constant (ka) were significantly greater after the morning dose. The time to maximum concentration (tmax) and elimination half-life (t1/2) of the morning and evening dosages did not differ. A significant correlation was observed between plasma propranolol concentration and %R in HR during exercise in the morning (r=0.74) and evening (r=0.63) trials, and the regression lines of the morning and evening treatments did not differ. The data indicate that the suppressive effect of propranolol on exercise-induced tachycardia was relatively greater after a morning than an evening dose; that propranolol was more rapidly absorbed from the gastrointestinal tract after the morning than the evening dosage; that diurnal changes in the activity of propranolol depend in part on the time of administration and its subsequent effect on plasma concentrations of the drug; and that the antagonist activity of propranolol relative to a given drug concentration may not differ between morning and evening treatments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265971
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  • 4
    Electronic Resource
    Electronic Resource
    Depression of frog gustatory neural responses to quinine-HCl after adaptation of the tongue to various taste stimuli (1978)
    Springer
    Cellular and molecular life sciences 34 (1978), S. 196-197 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary After the frog tongue was adapted to salt, sugar and bitter solutions, the amplitudes of initial phasic gustatory neural responses to quinine-HCl (Q-HCl) were depressed. However, adaptation to acid solutions did not affect the responses to Q-HCl.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01944674
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  • 5
    Electronic Resource
    Electronic Resource
    Change in taste preference related to aging of taste cells in rat (1978)
    Springer
    Cellular and molecular life sciences 34 (1978), S. 611-612 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Following the suppression of renewal of rat taste cells by vinblastine sulphate, the preference for sucrose decreased markedly while the aversion to quinine did not change. The results suggest that the sensitivity of taste cells to sucrose decreases with their aging, but the sensitivity to quinine increases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01936989
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  • 6
    Electronic Resource
    Electronic Resource
    Comparison of venodilatory effect of nicardipine, diltiazem, and verapamil in human subjects (1998)
    Springer
    European journal of clinical pharmacology 54 (1998), S. 31-34 
    Details
    ISSN: 1432-1041
    Keywords: Key words Diltiazem ; Verapamil ; Nicardipine ; Vein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: Venodilatory effects of calcium antagonists have not been fully investigated, especially in human subjects. The present study was undertaken to compare the direct venodilatory effects of nicardipine, diltiazem and verapamil using the dorsal hand-vein technique. Methods: In eight healthy male subjects, increasing doses (0.001, 0.01, 0.1, 1 and 10 μg · min−1) of these drugs and saline alone were infused, on four separate occasions, into the dorsal hand vein preconstricted with noradrenaline, and its diameter was measured by a linear-variable differential transformer. Result and conclusions: Diltiazem caused significant venodilation at a dose of 0.01 μg · min−1 or more, while verapamil and nicardipine only caused this effect at 1 μg · min−1 or more. The potency of the effect was diltiazem 〉 verapamil 〉 nicardipine. The venodilation at a dose of 1 μg · min−1 was 41.7%, 16.2% and 8.5%, respectively, for each drug. These findings indicate that the venodilatory effect of diltiazem is larger than that of verapamil and nicardipine in human subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050416
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  • 7
    Electronic Resource
    Electronic Resource
    A fungal suppressor of phytoalexiu production competes for the elicitor-receptor binding (1993)
    Springer
    Naturwissenschaften 80 (1993), S. 374-376 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01138796
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  • 8
    Electronic Resource
    Electronic Resource
    Functional cloning of centromere protein B (CENP-B) box-enriched alphoid DNA repeats utilizing the sequence-specific DNA binding activity of human CENP-Bin vitro (1994)
    Springer
    Chromosome research 2 (1994), S. 453-459 
    Details
    ISSN: 1573-6849
    Keywords: alphoid ; CENP-B ; CENP-B box ; centromere ; DNA-binding protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The centromere is a distinctive portion of the chromosome consisting of ‘centromere DNA’ and ‘centromere proteins’. Recently, a direct molecular interaction was discovered between human centromere protein B (CENP-B) and human centromeric alphoid repeats. This enabled us to isolate the CENP-B-targeted centromeric DNA sequences by positively utilizing the biologic activity of CENP-Bin vitro. In the previous model experiment, we found that oligonucleotides covering the CENP-B binding sequences were enriched by the DNA immunoprecipitation procedure. Here we apply the same technique to the direct isolation of a functional part of human centromeric DNA from a genomic DNA library. Restriction digestion of two isolated clones showed the typical repeating pattern of an alphoid family that is known to localize at the centromeric region of all human chromosomes. Sequence analysis showed that these two clones frequently contain the authentic CENP-B binding motif, CTTCGTTGGAAACGGGA, or a new one with one base replaced, CTTCGTTGGAAACGGGT. The frequent distribution of these motifs suggests that the isolated sequences are directly involved in the organization of centromeric heterochromatin at the primary constriction in conjunction with CENP-B.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01552868
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  • 9
    Electronic Resource
    Electronic Resource
    Hyperfine fields for B and N in nickel (1976)
    Springer
    Hyperfine interactions 2 (1976), S. 187-193 
    Details
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01021110
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  • 10
    Electronic Resource
    Electronic Resource
    Decoupling of the hyperfine interactions in12B ions by the external magnetic field (1976)
    Springer
    Hyperfine interactions 2 (1976), S. 401-402 
    Details
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01021190
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